Advance Search

Essential oil from Oliveria decumbens accelerates in vivo wound healing: a possible mechanism by the involvement of glycogen synthase kinase-3

Zahra Abdulqader Amin
Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Iraq.
Sargul H. Sofi
Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Iraq.
Hazem A. Albustani
Department of Basic sciences, College of Medicine, Hawler Medical University, Erbil, Iraq.
Sheila M. Nuraddin
Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Iraq.
Keywords:
Copyright and Licensing:

Copyright (c) 2022 ZAHRA ABDULQADER AMIN, Sargul H. Sofi, Hazem A. Albustani, Sheila M. Nuraddin (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Share:
Crossref
Scopus
Google Scholar
Europe PMC

Abstract

Background and objective: The development of new products for skin care and wound treatment is continuous, and herbal medicine plays an important role in the treatments. Oliveria decumbens, a plant from the family Apiaceae, has been reported to enclose many pharmacological properties. This study aimed to detect the effect of the essential oil of Oliveria decumbens as an antibacterial and wound healing agent.

Methods: The antibacterial properties of Oliveria decumbens were studied by the disk diffusion method. In addition, the excision model of wound healing was applied to rats, and the AutoDock method was used to study the mechanism of action.

Results: The essential oil extracted from Oliveria decumbens showed antibacterial activities against gram-positive and gram-negative bacteria, and the wound healing effect was comparable to the standard skin cream. Thymol was predicted to be the strongest binder of GSK-3 protein active site forming the most stable complex with hydrogen bond and hydrophobic interaction. The second-best binders were P-Cymene, Limonene, Gamma-Terpinene, and Carvacrol.

Conclusion: The observed data backed the original claim of antibacterial and wound healing properties of Oliveria decumbens extracted essential oil.

PDF
PDF

Metrics

Metrics Loading ...

References

  1. Guo Sa, DiPietro LA. Factors affecting wound healing. Journal of Dental Research. 2010;89(3):219–29. https://doi.org/10.1177/0022034509359125
  2. Gordillo GM, Bernatchez SF, Diegelmann R, Di Pietro LA, Eriksson E, Hinz B, et al. Preclinical models of wound healing: is man the model? Proceedings of the Wound Healing Society Symposium. Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA; 2013.
  3. Ritsu M, Kawakami K, Kanno E, Tanno H, Ishii K, Imai Y, et al. Critical role of tumor necrosis factor-α in the early process of wound healing in skin. Journal of Dermatology & Dermatologic Surgery. 2017;21(1):14–9. https://doi.org/10.1016/j.jdds.2016.09.001
  4. Maloy S, Hughes K. Brenner's encyclopedia of genetics: Academic Press; 2013.
  5. Aronson JK. Meyler's side effects of drugs: the international encyclopedia of adverse drug reactions and interactions: Elsevier; 2015.
  6. Neurath MF. Cytokines in inflammatory bowel disease. Nature Reviews Immunology. 2014;14(5):329–42. https://doi.org/10.1038/nri3661
  7. Steen EH, Wang X, Balaji S, Butte MJ, Bollyky PL, Keswani SG. The role of the anti-inflammatory cytokine interleukin-10 in tissue fibrosis. Advances in Wound Care. 2020; 9(4):184–98. https://doi.org/10.1089/wound.2019.1032
  8. Motamedi H, Darabpour E, Gholipour M, Seyyednejad S. Antibacterial effect of ethanolic and methanolic extracts of Plantago ovata and Oliveria decumbens endemic in Iran against some pathogenic bacteria. Int J Pharmacol. 2010;6(2):117–22. https://doi.org/10.3923/ijp.2010.117.122
  9. Amin G, Sourmaghi MS, Zahedi M, Khanavi M, Samadi N. Essential oil composition and antimicrobial activity of Oliveria decumbens. Fitoterapia. 2005;76(7-8):704–7. https://doi.org/10.1016/j.fitote.2005.06.009
  10. HAJI MH, Samadi N, MOZAFARIAN V, Rahimifard N, SHOEYBI S, Pirali HM. Chemical composition and antimicrobial activity of Oliveria decumbens volatile oil from West of Iran. 2010.
  11. Sajjadi S, Hoseini S. Essential oil constituents of Oliveria decumbens Vent. Journal of Essential Oil Research. 2002;14(3):220–1. https://doi.org/10.1080/10412905.2002.9699828
  12. Hojjati M, Ghodsi M. Chemical compositions and antimicrobial effects of Oliveria decumbens Vent essential oil. Second International and Sixth National Conference of Organic vs. Conventional Agriculture 2019.
  13. Alizadeh Behbahani B, Tabatabaei Yazdi F, Vasiee A, Mortazavi SA. Oliveria decumbens essential oil: Chemical compositions and antimicrobial activity against the growth of some clinical and standard strains causing infection. Microbial Pathogenesis. 2018;114:449–52. https://doi.org/10.1016/j.micpath.2017.12.033
  14. Valdivieso-Ugarte M, Gomez-Llorente C, Plaza-Díaz J, Gil Á. Antimicrobial, Antioxidant, and Immunomodulatory Properties of Essential Oils: A Systematic Review. Nutrients. 2019;11(11):2786. https://doi.org/10.3390/nu11112786
  15. Mahboubi M, Feizabadi MM, Khamechian T, Kazempour N, Zadeh MR, Sasani F, et al. The effect of Oliveria decumbens and Pelargonium graveolens on healing of infected skin wounds in mice. World Journal of Plastic Surgery. 2016; 5(3):259.
  16. Mahboubi M, Kazempour N, Mahboubi A. The efficacy of essential oils as natural preservatives in vegetable oil. Journal of Dietary Supplements. 2014;11(4):334–46. https://doi.org/10.3109/19390211.2014.887603
  17. Behbahani BA, Yazdi FT, Vasiee A, Mortazavi SA. Oliveria decumbens essential oil: Chemical compositions and antimicrobial activity against x
  18. the growth of some clinical and standard strains causing infection. Microbial Pathogenesis. 2018;114:449–52. https://doi.org/10.1016/j.micpath.2017.12.033
  19. HOJJATI M, GHODSI M, editors. Investigation of chemical compositions and antimicrobial effects of Oliveria decumbens vent essential oil. Book of Proceedings; 2019.
  20. Sofi SH, Nuraddin SM, Amin ZA, Al-Bustany HA, Nadir MQ. Gastroprotective activity of Hypericum perforatum extract in ethanol-induced gastric mucosal injury in Wistar rats: A possible involvement of H+/K+ ATPase α inhibition. Heliyon. 2020;6(10):e05249. https://doi.org/10.1016/j.heliyon.2020.e05249
  21. Amin ZA, Ali HM, Alshawsh MA, Darvish PH, Abdulla MA. Application of Antrodia camphorata promotes rat’s wound healing in vivo and facilitates fibroblast cell proliferation in vitro. Evidence-Based Complementary and Alternative Medicine. 2015;2015:317693. https://doi.org/10.1155/2015/317693
  22. Harish B, Krishna V, Kumar HS, Ahamed BK, Sharath R, Swamy HK. Wound healing activity and docking of glycogen-synthase-kinase-3-β-protein with isolated triterpenoid lupeol in rats. Phytomedicine. 2008;15(9):763–7. https://doi.org/10.1016/j.phymed.2007.11.017
  23. Taha MO, Bustanji Y, Al-Ghussein MA, Mohammad M, Zalloum H, Al-Masri IM, et al. Pharmacophore modeling, quantitative structure–activity relationship analysis, and in silico screening reveal potent glycogen synthase kinase-3β inhibitory activities for cimetidine, hydroxychloroquine, and gemifloxacin. Journal of Medicinal Chemistry. 2008;51(7):2062–77. https://doi.org/10.1021/jm7009765
  24. Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, et al. AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Journal of Computational Chemistry. 2009;30(16):2785–91. https://doi.org/10.1002/jcc.21256
  25. Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, et al. UCSF Chimera—a visualization system for exploratory research and analysis. Journal of Computational Chemistry. 2004;25(13):1605–12. https://doi.org/10.1002/jcc.20084
  26. O'Boyle NM, Banck M, James CA, Morley C, Vandermeersch T, Hutchison GR. Open Babel: An open chemical toolbox. Journal of Cheminformatics. 2011;3(1):33. https://doi.org/10.1186/1758-2946-3-33
  27. Trott O, Olson AJ. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Journal of Computational Chemistry. 2010;31(2):455–61. https://doi.org/10.1002/jcc.21334
  28. Ecormier MA, Wilson K, Lee AF. Structure–reactivity correlations in sulphated-zirconia catalysts for the isomerisation of α-pinene. Journal of Catalysis. 2003;215(1):57–65. https://doi.org/10.1016/S0021-9517(02)00150-1
  29. Fierascu I, Dinu-Pirvu CE, Fierascu RC, Velescu BS, Anuta V, Ortan A, et al. Phytochemical profile and biological activities of Satureja hortensis L.: a review of the last decade. Molecules. 2018;23(10):2458. https://doi.org/10.3390/molecules23102458
  30. Lüddeke F, Harder J. Enantiospecific (S)-(+)-linalool formation from β-myrcene by linalool dehydratase-isomerase. Zeitschrift für Naturforschung C. 2011;66(7-8):409–12. https://doi.org/10.1515/znc-2011-7-813
  31. Santos SR, Melo MA, Cardoso AV, Santos RL, de Sousa DP, Cavalcanti SC. Structure–activity relationships of larvicidal monoterpenes and derivatives against Aedes aegypti Linn. Chemosphere. 2011;84(1):150–3. https://doi.org/10.1016/j.chemosphere.2011.02.018
  32. Grillo I, Morfin I, Prévost S. Structural characterization of Pluronic micelles swollen with perfume molecules. Langmuir. 2018;34(44):13395–408. https://doi.org/10.1021/acs.langmuir.8b03050
  33. Ramos M, Jiménez A, Peltzer M, Garrigós MC. Characterization and antimicrobial activity studies of polypropylene films with carvacrol and thymol for active packaging. Journal of Food Engineering. 2012;109(3):513–9. https://doi.org/10.1016/j.jfoodeng.2011.10.031
  34. Shulgin AT. Possible implication of myristicin as a psychotropic substance. Nature. 1966;210(5034):380–4. https://doi.org/10.1038/210380a0
  35. Kobets T, Duan J-D, Brunnemann KD, Etter S, Smith B, Williams GM. Structure-activity relationships for DNA damage by alkenyl benzenes in Turkey egg fetal liver. Toxicological Sciences. 2016;150(2):301–11. https://doi.org/10.1093/toxsci/kfv322
  36. Hayase M, Yodokawa S, Kurabayashi T, Adachi E, Tanno T. Simulated disordered-to-ordered phase transition of nonadecane. Chemical Physics. 2020;532:110697.https://doi.org/10.1016/j.chemphys.2020.110697
  37. Eftekhari M, Ardekani MRS, Amin M, Attar F, Akbarzadeh T, Safavi M, et al. Oliveria decumbens, a bioactive essential oil: Chemical composition and biological activities. Iranian Journal of Pharmaceutical Research. 2019;18(1):412.
  38. Vazirzadeh A, Jalali S, Farhadi A. Antibacterial activity of Oliveria decumbens against Streptococcus iniae in Nile tilapia (Oreochromis niloticus) and its effects on serum and mucosal immunity and antioxidant status. Fish & Shellfish Immunology. 2019;94:407–16. https://doi.org/10.1016/j.fsi.2019.09.025
  39. Motamedi H, Darabpour E, Gholipour M, Nejad SS. Oliveria decumbens Endemic in Iran Against Some Pathogenic Bacteria. Int J Pharmacol. 2010;6(2):117–22. https://doi.org/10.3923/ijp.2010.117.122
  40. Mahboubi M, Taghizadeh M, Khamechian T, Tamtaji OR, Mokhtari R, Talaei SA. The wound healing effects of herbal cream containing Oliveria decumbens and Pelargonium graveolens essential oils in diabetic foot ulcer model. World Journal of Plastic Surgery. 2018;7(1):45.
  41. Akkol EK, Koca U, Pesin I, Yilmazer D. Evaluation of the wound healing potential of Achillea biebersteinii Afan.(Asteraceae) by in vivo excision and incision models. Evidence-Based Complementary and Alternative Medicine. 2011;2011:474026. https://doi.org/10.1093/ecam/nep039
  42. Günal MY, Okçu Heper A, Zaloğlu N. The effects of topical carvacrol application on wound healing process in male rats. PHCOG J. 2014;6(3):10–4. https://doi.org/10.5530/pj.2014.3.2
  43. Costa MF, Durço AO, Rabelo TK, Barreto RdSS, Guimarães AG. Effects of Carvacrol, Thymol and Essential Oils Containing Such Monoterpenes on Wound Healing: A Systematic Review. Journal of Pharmacy and Pharmacology. 2019;71(2):141–55. https://doi.org/10.1111/jphp.13054
How to Cite
Amin, Z. A., H. Sofi, S. ., A. Albustani, H., & M. Nuraddin, S. . (2022). Essential oil from Oliveria decumbens accelerates in vivo wound healing: a possible mechanism by the involvement of glycogen synthase kinase-3. Zanco Journal of Medical Sciences (Zanco J Med Sci), 26(2), 118–126. https://doi.org/10.15218/zjms.2022.013

Send mail to Author

Send Cancel