Prospective study on effect of Helicobacter pylori on gastroesophageal reflux disease

Authors

  • Sabah Jalal Shareef Department of Surgery, College of Medicine, Hawler Medical University, Erbil, Iraq.

DOI:

https://doi.org/10.15218/zjms.2017.022

Keywords:

Gastroesophageal reflux disease, Helicobacter pylori infection, Symptom severity, Endoscopic finding

Abstract

Background and objective: The Helicobacter pylori infections role in etiology of peptic ulcer is well known, but its role in gastroesophageal reflux disease is one of the important issues which has to be confirmed. We tried to find out the effect of Helicobacter pylori infection on gastroesophageal reflux disease.

Methods: The current study was done on 100 patients with gastroesophageal reflux disease from January 1st to June 30th, 2014 in Rizgary Teaching Hospital, Erbil city. The diagnosis was made by history, clinical examination, and endoscopy. Helicobacter pylori infection was confirmed by gastric biopsy and histopathological examination. We tried to find out the effects of Helicobacter pylori infection in gastroesophageal reflux disease patients and its eradication on their symptoms. The data was analyzed with the statistical package for the social sciences (version 18).

Results: The mean age ± SD of participants was 37.13 ± 12.5 (17-75 years). The prevalence of Helicobacter pylori infection was 75%. The endoscopy showed that 50 out of 75 patients had erosive esophagitis and 25 out of 75 patients had normal appearance known as non-erosive esophagitis. The study showed no significance of its eradication on symptoms of gastroesophageal reflux disease.

Conclusion: The effect of Helicobacter pylori infection in gastroesophageal reflux disease patients was significant regarding endoscopic finding while inversely related to symptoms severity. The eradication of infection did not cause improvement in symptom severity i.e. triple therapy not advised in the course of treatment.

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References

Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, et al. The Montreal definition and classification of gastro esophageal reflux disease: a global evidence-based consensus. Am J Gastroenterology 2006;101(8): 1900–20;

Jobe BA, Hunter JG, Watson DI. Esophagus and diaphragmatic hernia. In: Brunicardi F, Andersen D, Billiar T, Dunn D, Hunter J, Matthews J, (editors). Schwartz's Principles of Surgery, 10th ed. New York: Mc Graw-Hill; 2015. P. 966.

Dent J, El-Serag HB, Wallander MA, Johansson S. Epidemiology of gastroesophageal reflux disease: a systematic review. Gut 2005;54(5): 710–7. doi: 10.1136/gut.2004.051821

Moayyedi P, Talley NJ. Gastro-esophageal reflux disease. Lancet 2006; 367(9528): 2086–100. doi: 10.1016/s0140-6736(06)68932-0

Jacobson BC, Somers SC, Fuchs CS, Kelly CP, Camargo CA. Body-mass index and symptoms of gastroesophageal reflux in women. N Engle J Med 2006; 354(22): 2340–8. doi: 10.1056/nejmoa054391

El-Omar EM, Oien K, El-Nujumi A, Gillen D, Wirz A, Dahill S, et al. Helicobacter pylori infection and chronic gastric acid hyposecretion. Gastroenterology 1997; 113(1): 15–24. doi: 10.1016/s0016-5085(97)70075-1

Miwa H, Go MF, Sato N H. pylori, and gastric cancer: the Asian enigma. Am J Gastroenterology 2002; 97(5): 110612.

Fujiwara Y, Arakawa T. Epidemiology and clinical characteristics of GERD in the Japanese population. J Gastroenterol 2009;44(6): 518–34. doi: 10.1007/s00535-009-0047-5.

Koike T, Ohara S, Sekine H, Iijima K, Abe Y, Kafo K, et al. Helicobacter pylori infection prevents erosive reflux oesophagitis by decreasing gastric acid secretion. Gut 2001;49(3): 330–4. doi: 10.1136/gut.49.3.33

El Serag HB, Sonnenberg A. Opposing time trends of peptic ulcer and reflux disease. Gut1998; 43:327–33. [Pub Med].

Richter JE, Falk GW, Vaezi MF. Helicobacter pylori and GERD: the bug may not be all bad. Am J Gastroenterol 1998;93:1800–2.

Loffeld RJ, Werdmuller BF, Kuster JG, Perez GI, Blaser MJ, Kupers EJ, et al. Colonization with cag A positive Helicobacter pylori strains inversely associated with reflux esophagitis and Barrett’s esophagus. Digestion 2000;62:95–9.

Hamada H, Haruma K, Mihara M, Kamada T,Yoshihara M,Sumii K,et al. High incidence of reflux oesophagitis after eradication therapy for Helicobacter pylori: impacts of a hiatal hernia and corpus gastritis.Aliment Pharmacol Ther 2000;14:729–35.

Labenz J, Malfertheiner P. Helicobacter pylori in gastro-esophageal reflux disease: causal agent, independent or protective factor? Gut 1997; 41:277–815

Richter JE. The Cleveland Clinic Effect of Helicobacter pylori eradication on the treatment of gastro-esophageal reflux disease Gut. 2004 ; 53(2): 310–11.

Iijima K, Sekine H, Koike T, Imatani A, Ohara S, Shimosegawa T. Long-term effect of Helicobacter pylori eradication on the reversibility of acid secretion in profound hypochlorhydria. Aliment Pharmacol Ther 2004;19:1181–8. 10.1111/j.1365-2036.2004.01948.x

Fukuchi T. Influence of cure of Helicobacter pylori infection on gastric acidity and gastroesophageal reflux: a study by 24-h pH monitoring in patients with gastric or duodenal ulcer. J Gastroenterology 2005; 40(4):350-60.

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Published

2017-07-29

How to Cite

Shareef, S. J. (2017). Prospective study on effect of Helicobacter pylori on gastroesophageal reflux disease. Zanco Journal of Medical Sciences (Zanco J Med Sci), 21(2), 1696–1700. https://doi.org/10.15218/zjms.2017.022

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Original Articles