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Histopathological and Immunohistochemical Approach for Characterization of Malignant Round Cell Tumors

Intisar S. Pity
Department of Histopathology, College of Medicine, University of Duhok, Duhok, Iraq
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  • Submited: November 5, 2018
  • Published: November 5, 2018

Abstract

Background and Objectives: To analyze the role of immunohistochemistry in characterization of malignant round cell tumors

Patients and Methods: Immunohistochemical staining (IHC) with (monoclonal or polyclonal) antibodies was performed on 127 cancer cases reported as malignant round cell tumors over a 12 month period from July 2008 through August 2009. Setting: Department of histopathology, Duhok Central Labs

Results: Malignant round cell tumors were more frequently located in the respiratory tract 30 (23.6%) followed by gastrointestinal tract 25 (19.7%), lymph node 19 (14.9%), and bone/soft tissue 19 (14.9%). Among these, 75 (82.7%) cases were primary and 22 (17.3%) metastatic. Application of immunohistochemistry resulted in characterization of 112 (88.2%) cases. Non-Hodgkin lymphoma 21 (16.5%) was at the top of the diagnosed list followed by adenocarcinoma 20 (15.7%), sarcoma 17 (13.4%), and small undifferentiated carcinoma 15 (11.8%).

Conclusions: Immunohistochemistry is a very helpful tool for characterization of malignant round cell tumors.

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How to Cite
Pity, I. S. (2018). Histopathological and Immunohistochemical Approach for Characterization of Malignant Round Cell Tumors. Zanco Journal of Medical Sciences (Zanco J Med Sci), 14(1 Special), 144–150. Retrieved from https://zjms.hmu.edu.krd/index.php/zjms/article/view/552

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