Helicobacter Pylori infection among Dyspeptic Patients Referred for Endoscopy

Authors

  • Mohammad A. Sheikhani Department of Medicine, College of Medicine, University of Sulaimani, Sulaimania, Iraq.
  • Taha A. Alkarbuly Department of Medicine, College of Medicine, University of Sulaimani, Sulaimania, Iraq.
  • Pshko Tahir Muhammad Department of Medicine, College of Medicine, University of Sulaimani, Sulaimania, Iraq.

Keywords:

Dyspepsia, H.Pylori, Endoscpy

Abstract

Background: Dyspepsia is a relatively common clinical condition encountered by primary care physicians, lately H.pylori has been related to duodenal and gastric ulcers, and to a lesser extent, gastric malignancy. Screening for H.pylori can now be done by noninvasive techniques.

Aims: Evaluating frequency of H.pylori infection in dyspeptic patients in relation to age, gender, patient symptoms and endoscopic findings.

Patients and Methods: This prospective and descriptive study was conducted in Kurdistan Center for Gastrology and Hepatology (KCGH) on 86 dyspeptic patients, all the patients underwent Oesophageogastroduodenoscopy to find the cause of dyspepsia, a blood sample collected for determination of serum IgG for H.pylori.

Results: H.pylori account for 54(62.7%) of 86 dyspeptic patient. The incidence of the infection was higher in female patients (p=0.03), there was statistically significant difference between female and male (p=0.02). H.pylori infection is common in age groups 21-40 and 41-60 (26.7% and 23.2%) respectively, there was no relation between patient symptoms and H.pylori infection (p>0.05) except vomiting, loss of appetite and weight loss (p<0.05) also there was no association between endoscopic findings and H.pylori infection (p>0.05) except for gastric and duodenal erosion (p<0.0001).

Conclusion: H.pylori infection is frequent among dyspeptic patients, the infection is more common between ages 21-60 years and H.pylori infection has no relation to symptoms and endoscopic findings.

Metrics

Metrics Loading ...

References

TNJ, Zinsmeister AR, Schleck CD, et al.Dyspepsia&dyspepsia subgroups: Gastroenterology 1992; 102,4 Pt 1:1259–1268.

K Musana, SH. Yale, and KA. Lang. Managing Dyspepsia. Clin Med Res.2006; 4,4: 337–342.

TNJ&Vakil N. Practice Parameters Committee of the ACG Guidelines for the management of dyspepsia. Am J Gastroenterol 2005; 100:2324–2337.

Talley NJ, Colin-Jones D, Koch KL, et al. Functional dyspepsia: a classification with guidelines for management.Gastroenterol Int 1991; 4:145-160.

Holtmann G and Talley NJ. Functional dyspepsia. Drugs 1993; 45:918-930

Armstrong D. H pylori&dyspepsia. Scand J Gastroenterol 1996; 31, 215:S38-S47.

Morain C&Buckley M. H.pylori&dyspepsia. Scand J Gastroenterol 1996; 31, 214:S28-S30.

Richter JE. Dyspepsia: organic causes& differential characteristics from functional dyspepsia. Scand J Gastroenterol 1991; 182:S11-S16.

Al-Moagel MA, Evans DG, Abdulg hani ME, et al. Prevalence of Helicobacter in Saudia Arabia,

&comparison of those with and without UGI symptoms. Am J Gastroenterology 1990; 85:944-948.

Abdul-Wahab AM and Bin-Dayna KM. Helicobacter pylori: association with UGI disease in Bahrain. Bahrain Med Bull 1994; 16:78-81.

Britt DP, Barakat MH, Tungekar MF, et al. H pylori in Kuwait. J Clin Pathol 1990; 43:987-991.

Talley NJ et al. Dyspepsia: A population-based study. Gastroenterology 1992; 102:1259-1262.

Talley NJ, Colin-J D, Koch KL, et al. Functional dyspepsia:Gastroenterol Int 1992; 4:145-147.

Tack J, Talley NJ, Camilleri M, et al. Functional gastroduodenal disorders. GE 2006; 130:1466-7.

Kurata JH, Nogawa AN&Everhart, JE. dyspepsia in primary care. Dig Dis Sci 2002; 47:797-799.

Management of dyspepsia: report of a working party. Lancet 1988; 1:576-577.

Koch, KL&Stern, RM. Functional disorders of the stomach. Semin Gastrointest Dis 1996; 7:185-8.

Malagelada JR. Functional dyspepsia. Insights on mechanisms and management strategies. Gastroenterol Clin North Am 1996; 25:103-104.

Aroori S. Helicobacter pylori. Gastroenterol Today 2001; 5: 131-133.

Klauser AG, Schindlbeck NE&Muller-Lissner SA. Symptoms in DERD. Lancet 1990; 335:205-8.

Moayyedi, P&Axon, AT. Usefulness of the LR in the diagnosis of dyspepsia &GERD. Am J Gastroenterol 1999; 94:3122-3125.

Gillen D and McColl KE. Does concern about missing malignancy justify endoscopy in uncomplicated dyspepsia in patients aged less than 55? Am J Gastroenterol 1999; 94:2329-2331.

Talley, NJ. Editorial: Gallstones and upper abdominal discomfort. Innocent bystander or a cause of dyspepsia? J Clin Gastroenterol 1995; 20:182-185.

Thompson WG, Longstreth G, Drossman DA, et al. Functional bowel disorders and functional abdominal pain. Gut 1999; 45 Suppl 2:1143-1145.

Spiegel BM, Farid M, Dulai GS, et al. Comparing rates of dyspepsia with Coxibs vs. NSAID+PPI: a meta-analysis. Am J Med 2006; 119:448-452.

Karamanolis G, Caenepeel P, Arts J, et al. Association of the predominant symptom with clinical characteristics&pathophysiological mechanisms in functional dyspepsia. Gastroenterology 2006; 130:296-299.

Moayyedi P, Talley NG, Fennerty MB, et al.Can the clinical history distinguish between organic and functional dyspepsia?JAMA 2006; 295:1566-1569.

Logan, Robert P H; Walker, et al.Epidemiology&diagnosis of H pylori. BMJ 2001; 323: 920–922.

Marshall BJ. "Unidentified curved bacillus on gastric epithelium in active chronic gastritis". Lancet 1 (1983); 8336: 1273–1275.

Marshall BJ and Warren JR. "Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration". Lancet 1 (1984); 8390: 1311–1315.

Hidekazu S,Tatsuhiro M,Sachiko N,et al.Current consensus on the diagnosis and treatment of H.pylori associated gastroduodenal disease.Keio J Med 2003;52,3:163-173.

L Morris &Brown.H pylori: Epid&routes of transmission. Epidemiologic Rev 2000; 22, 2:283-7

Eduardo L., Pelayo C., Regina M., et al.Role and limitations of epidemiology in establishing a causal association. Seminars in Cancer Biology 2004; 14, 6:413-426.

Periklis Apostolopous,Irene Vafiadis-Zouboulis,Michael Tzivras, et al.Helicobacter pylori infection in Greece:The changing prevalence,BMC Gastroenterology .2002 ;2:11;12-18.

Karen J.Goodmanl and Myles Cockburn.The role of epidemiology in understanding the health effects of Helicobacter pylori .Epidemiology. 2001; 12, 2:266-271.

German R, Guadalupe A. and Geny F.Helicobacter pylori: Recent advances in the study of its pathogenicity and prevention.Publica Mex. 2001; 43, 3:237-247.

K.Seth, S.Kakkar and S.manchanda.Role of biopsy from gastric corpus in diagnosis of Helicobacter pylori infection in patients on acid suppression therapy.MJAFI.2003;5,3:216-217.

Richard Saad and William d. Chey.A clinicians guide to managing Helicobacter pylori infection.Cleveland Clinic Journal of Medicine. 2005; 72, 2: 110-112.

Reilly J. Appropriate prescribing for Helicobacter pylori infection. Located at: Peptic ulcer disease: Update with the experts, Medical Education Collaborative, Golden, Colorado. 2001

Ho B& Marshall BJ. Accurate diagnosis.Gastroenterol Clin North Am 2000; 29, 4:853–862.

Loy CT, Irwig LM, Katelaris PH, et al. Do commercial serological Kits for H pylori differ in accuracy? Ametaanalysis.AmJ Gastroenterol1996; 91:1138–1144.

Chey WD, Murthy U, Shaw S, et al. A comparison of three finger stick, Whole blood antibody tests for H pylori infection: a United States, multicentertrial. Am J Gastroenterol 1999; 94:1512–1516.

Chey WD and Scheiman JM. Chapter 20: Peptic Ulcer Disease. In: McQuaid K, editor. Current Diagnosis and Treatment in Gastroenterology. 2nd ed.NewYork:McGraw-Hill;2003:323–341.

Graham DY&Klein PD.Diagnosis of H pylori by breath test. Gastroenterol Clin North Am 2000; 29,4:885–893.

Del Valle J, Chey WD and Scheiman JM. Acid peptic disorders. In: Alpers DH, editor. Textbook of Gastroenterology. Philadelphia: Lippincott Williams andWilkins;2003:1328–1376.

Chey WD. Diagnosis of H pylor. Gastroenterol Clin North Am 2000; 29, 4:895–902.

Chey WD, Metz DC, Shaw S,et al. Appropriate timing of the 14C-urea breath test to establish eradication of Helicobacter pylori infection. Am J Gastroenterol 2000; 95:1171–1174.

Chey WD, Murthy U, Toskes P, et al. The 13C-urea blood test accurately detects active H pylori: a United States, multicenter trial. Am J Gastroenterol 1999; 94:1522–1524.

Vaira D, Menegatti M, Ricci C, et al.Accurate diagnosis of H pylori. Stool tests. Gastroenterol Clin North Am 2000; 29, 4:917–923.

Odaka T, Yamaguchi T, Koyama H, et al. Evaluation of the Helicobacter pylori stool antigen test for monitoring eradication therapy. Am J Gastroenterol 2002; 97:594–599.

Vaira D, Vakil N, Menegatti M, et al. The stool antigen test for detection Of Helicobacter pylori after eradication therapy. Ann Intern Med 2002; 136:280–287.

Bravo LE, Realpe JL, Campo C, et al. Effects of acid suppression and bismuth medications on the performance of diagnostic tests for Helicobacter pylori infection. Am J Gastroenterol 1999; 94:2380–2383.

Talley, Axon , Bytzer , et al. Management of uninvestigated a& functional dyspepsia. Aliment Pharmacol Ther 1999; 13:1135-1148.

Westbrook JA, McIntosh JH, Duggan JM. Accuracy of provisional Diagnoses of dyspepsia in patients undergoing first endoscopy. Gastrointestinal Endoscopy 2001; 53:283-288.

How den CW. For what conditions is there evidence-based justification for treatment of Helicobacter pylori infection? Gastroenterology 1997; 113:S107-112.

Talley RJ and Hunt R. What role does Helicobacter pylori play in dyspepsia and nonulcer dyspepsia? Arguments for and against H pylori being associated with dyspeptic symptoms. Gastroenterology 1997; 113:S67-77.

Mc K, Murray L,et al. Symptomatic benefit to eradicate H pylori.NEJM 1998; 339:1869-1874.

Lassen AT, Pedersen FM, Bytzer P, et al. H pylori test. Lancet 2000; 356:455-460.

Silverstein, Petterson. Initial endoscopy or empirical therapy.Gastroenterology96; 110:72-83.

Groeneveld, Lieu et al. Quality of life measurement in dyspepsia. AJGE 2001; 96:338-346.

Veldhuyzen van Zanten SJO, Jones MJ, Verlinden M, et al. Efficacy of Cisapride and Dom-peridone in functional (nonulcer) dyspepsia: a meta-analysis. Am J Gastroenterology 2001; 96:689-6.

Parsonnet J, Harris RA, Hack HM, et al. Modeling cost effectiveness of H pylori screening to prevent gastric cancer. Lancet 1996; 348:150-154.

Fuad A.Baban&Mohammad O.Mohammad.The prevalence of H. (JZS) 2003; A 6, 1:1-8.

Zana Tahseen A.A comparative study among biopsies from antrum, body&incicura angularis of stomach in diagnosis of chronic gastritis with correlation to H pylori. 2007; 4.1:72-73.

Haim Shmuely,Samson Obure,Douglas J.Passaro,et al.Dyspepsia symptoms and Helicobacter pylori infection,Nakuru,Kenya.Emerging infection disease 2003;9,l 9:1103-1107.

Rajesh K,B,Kapoor, et al.Clin profile in H.pylori positives in Jammu.JK science 2006;8,l 3:148-0.

Rathbone BJ, Wyatt J & Heatley RV. Symptomatology in C. pylori;Gut 1988; 29:A147-149.

Sobala GM, Dixon MF and Axon ATR. H. pylori is not associated with a distinct dyspeptic syndrome. Gut 1989; 30:A733-734.

Strauss RM, Wang TC, Kelsey PB, et al. Association of H Pylori infection with dyspeptic symptoms.Gastroduodenoscopy. Am J Med 1990; 89:464-469.

Tsega E, Gebre W, Manley P,et al. Helicobacter pylori, gastritis and non-ulcer dyspepsia in Ethiopian patients. Ethiop Med J 1996; 34:65-71.

Eman A.Abahussain, Fuad A.M.Hasan and Paul J.Nicholls.Dyspepsia and Helicobacter pylori infection: Analysis of 200 Kuwaiti patients referred for endoscopy.Annals of Saudi Medicine 1998; 18, 6:502-505.

Downloads

Published

2018-10-29

How to Cite

Sheikhani, M. A., Alkarbuly, T. A., & Muhammad, P. T. (2018). Helicobacter Pylori infection among Dyspeptic Patients Referred for Endoscopy. Zanco Journal of Medical Sciences (Zanco J Med Sci), 14(1 Special), 37–43. Retrieved from https://zjms.hmu.edu.krd/index.php/zjms/article/view/489

Issue

Section

Original Articles