Clinical and haematological parameters in adult AML patients: a four year experience at Nanakaly hospital for blood diseases

Ranan K. Pouls; Rawand P. Shamoon; Nawsherwan S. Muhammed

doi:10.15218/zjms.2012.0035

Authors

Ranan K. Pouls Department of Pathology and Haematology, College of Medicine, Hawler Medical University, Erbil, Iraq
Rawand P. Shamoon Department of Pathology and Haematology, College of Medicine, Hawler Medical University, Erbil, Iraq
Nawsherwan S. Muhammed Department of Pathology and Haematology, College of Medicine, Hawler Medical University, Erbil, Iraq

DOI:

https://doi.org/10.15218/zjms.2012.0035

Keywords:

Acute myeloid leukaemia, FAB classification, clinical and haematological pa-rameters

Abstract

Background and objectives: In adults, acute myeloid leukaemias constitute 80% of all acute leukaemia cases; its incidence progressively increases with age To define the clinical and haematological parameters of adult acute myeloid leukaemia in Erbil City. Methods: A painstaking analysis of hospital records of 94 adult patients with acute myeloid leukaemia was undertaken. The cases were diagnosed and managed at Nanakaly hospital during the years 2006-2009. Diagnosis was based on peripheral blood and marrow findings. The myeloid origin was confirmed by cytochemistry, and morphological subtyping was done according to the French-American-British (FAB) criteria. Microsoft excel version 2007 was employed for carrying out statistical analysis. Results: The studied group included 58 males and 36 females (M: F = 1.6:1). Their ages ranged between 16 and 75 years with a mean age of 33.8 years. Pallor was the commonest presenting feature (70.2%) followed by bleeding (22.3%) then fever (7.5%). The mean value of Hb was (7.6) g/dl, WBCs (34.5 x10⁶/L), platelets (39.6 x10⁹/L); the percentage of blast cells in peripheral blood was 42.5% and in the bone marrow was 65.9%. AML-M2 was the most frequent FAB subtype 24.4%. Conclusion: AML was commoner in males than in females (1.6:1). AML-M2 was the commonest FAB subtype. Pallor was the commonest presenting feature. Sudan black-B stain was a useful tool in the diagnosis of myeloid leukaemia .

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