Evaluation of serum fucose and protein bound fucose on myocardial infarction patients in Erbil city

Authors

  • Dler Rostum Ali Department of Clinical Biochemistry, College of Medicine, Hawler Medical University, Erbil, Iraq.
  • Tayfoor Jalil Mahmoud Department of Clinical Biochemistry, College of Medicine, Hawler Medical University, Erbil, Iraq.
  • Hamid G. Hassan Department of Biochemistry, Ibn Al-Haitham College, Baghdad University, Baghdad, Iraq.

DOI:

https://doi.org/10.15218/zjms.2012.0007

Keywords:

TF, PBF, MI

Abstract

Background and objectives: L-fucose is a methyl pentose similar to L-galactose, except for the loss of the alcohol group on carbon No.6. It is found in human serum bound to proteins by covalent bonding and it is a member of a large group of compounds known as glycoproteins Glycoproteins determine and steer up the vital functions of plasma membranes, e.g. cell-cell recognition, growth control, information uptake mediated via hormones or toxins and the attachment of antibodies. The aim of the current study is to measure the serum concentrations of these parameters on both the healthy individuals and the myocardial infarction patients.

Methods: The existing study has been initiated and implemented in earnest over the period commenced from February 2009 to October 2010 materialised on 100 healthy volunteer individuals countered to 110 (newly diagnosed myocardial infarction) patients. Serum total fucose and protein bound fucose were measured by UV/VIS spectrophotometery.

Results: The mean concentrations of serum fucose and protein bound fucose were significantly being higher on my ocardial infarction patients versus those of the control individuals.

Conclusion: in order to envisage the negative impact on the heart muscle can be judged by the increase in serum level of fucose and the subsequent protein bound fucose on the myocardial infarction patients, thus, they can be labelled as the biomarkered for the myocardial infarction.

Metrics

Metrics Loading ...

References

Tim K. and Beverley K. http://www.patient.co.uk/health/Myocardial-Infarction-(Heart-Attack).htm. 2010.

Kannel W. B. Silent myocardial ischemia and infarction: insights from the Framingham Study. Cardiol. Clin. 1986; 4 (4): 583-91.

Elena B., Yochai B. and Joseph E. Electrocardiographic diagnosis of acute myocardial infarction: Current concepts for the clinician. American Heart Journal 2001; 141(4): 507-17.

Jonathan K. Diagnosis of acute myocardial infarct with ventricular paced rhythm. Emergency Medicine 2003; 15(1): 100-03.

Peter L, Robert O. B, Douglas L. M. and Douglas P. Z. Braunwald Heart Disease: a textbook of cardiovascular medicine, 8th edition, W.E.Saunders, Philadelphia, USA, 2007.

Daniel J. and John B. Fucose: biosynthesis and biological function in mammals. Glycobiology 2003; 13(7): 41-53.

Alan W. Fucose. e-Newsletter. American International Association of Nutritional Education, (www.aianeduc.com), 2006.

Francis E., Murray S., James M. and Ernest F. Serum fucose in the diagnosis of breast cancer. Cancer 1971; 28: 1575-79.

Abbas L. B. Changes in α-L-Fucose and related parameters level in leukemia. Phd thesis, University of salahaddin, College of medicine-Erbil- Iraq.2004

AL-Haidary S. M. Evaluation of α-L-Fucose and related parameters in different types of diabetes mellitus). MSc. thesis, Baghdad University Ibn AL-Haitham College of education Iraq.2004

Takeshi S., Kazuki Y., Hiroko Y., Kanako H., Fumitsugu H., et al. Rapid, simple enzymatic assay of free L-Fucose in serum and urine, and its use as a marker for cancer, cirrhosis, and gastric ulcers. Clinical Chem. 1990; 36(3): 474-76.

Vijayalakshmi S., Geetha A. and Annie S. J. A biochemical study on the level of lipids and glycoproteins in the serum and platelets of liver cirrhotic bleeders. Acta Biochimica Polonica. 2006; 53(1): 213-20.

Peter V. and Werner R. Different turnover of fucose residues in plasma membranes of rat liver and morris hepatoma 7777. Biochem. J. 1980; 190: 51-55.

Robert K., Daryl G., Peter A. and Victor W. Harper’s Illustrated Biochemistry. 26th edition, McGraw-Hill, USA, 2003.

Dische Z. and Shettles L. A specific color reaction of methylpentoses and a spectrophotometric micromethod for their determinations. J. Biol. Chem. 1948; 175: 595-603.

Lindberg G., Rastam L., Nilsson-EhleSerum P. et al. Sialic acid and sialoglycoproteins in asymptomatic carotid artery atherosclerosis. Atherosclerosis 1999; 146: 65–69.

Snyder S., Coodley E., Durham B., and pennock R. Serum glycoproteins in coronary artery disease. Circulation. 1977; 56(3): 359-62.

Mukesh N., Ojha1 S., Ranjit K. Changes in levels of serum glycoproteins in major depressive disorders. Indian Journal of Clinical Biochemistry. 2005; 20(2):154-157.

Additional Files

Published

2012-04-01

How to Cite

Ali, D. R., Mahmoud, T. J., & Hassan, H. G. (2012). Evaluation of serum fucose and protein bound fucose on myocardial infarction patients in Erbil city. Zanco Journal of Medical Sciences (Zanco J Med Sci), 16(1), 40–44. https://doi.org/10.15218/zjms.2012.0007

Issue

Section

Original Articles