A double blind comparative study of the effect of nimesulide and naproxen on postoperative pain and swelling following periradicular surgery
DOI:
https://doi.org/10.15218/zjms.2013.0041Keywords:
Nimesulide, Naproxen, Postoperative pain and swelling, Periradicular surgeryAbstract
Background and objective: Pain and swelling are common postoperative complications that occur after periradicular surgery. A double blind comparative study was, therefore, designed to evaluate the effect of nimesulide and naproxen on the postoperative pain and swelling following periradicular surgery on one of the upper anterior teeth.
Methods: Sixty patients with a periapical lesion that required periradicular surgery were included in the study. They were divided into three groups according to the type of the postoperative analgesia they are going to administered.
Group I: Nimesulide administered group.
Group II: Naproxen administered group.
Group III: Placebo administered group.
Patients of each group were informed about the nature of the study and given the same shape of capsules. They are asked to assess their postoperative pain and swelling for 5 days by using the visual analogue scale (VAS).
Results: The results showed that both nimesulide and naproxen are effective in reducing the postoperative pain and swelling following periradicular surgery, and the nimesulide is found better than naproxen in this regard.
Conclusion: In this study both nimesulide and naproxen were significantly more effective than their corresponding placebo for reducing postoperative pain and swelling following periradicular surgery, but nimesulide administered group expressed significantly little pain in comparison to naproxen administered group, and the nimesulide administered group showed lesser swelling in the 2nd and 3rd postoperative day than those administered with naproxen.
Metrics
References
Molven O.: The frequency, technical standard and result of endodontic therapy. International Endodontic Journal. 2004, 29:347-84.
Hammond D.L.: Control system for nociceptive afferent processing the descending inhibitory pathway. Australian dental journal. 2002, Vol. 80, No.5.
Seymour R.A. and Walton J.G.: Pain control after third molar surgery. Journal of oral and maxillofacial surgery. 2001, 71: 1205-7.
Portenoy R.K.: Basic mechanism in pain management. Journal of Neuroscience. 2001, 79: 371-7.
Pasero C., Paice J.A. and McCcaffery M.: Basic mechanism underlying the cause and effects of pain. American journal of medicine. 2006, 84:509-11.
Woolf C.J.:Recent advances in the pathophysiology of acute pain. Eng.J.Med. 2004, Vol.21: 121-32.
Cooper S.A. and Desjardin P.J.: Peripherally acting non-opioid-analgesic. The journal of clinical pharmacology. 2006, Vol. 15, 65-70.
Troullous E.S. et al: Comparism of NSAIDs and methylprednisolone for acute pain and trismus. J. Can.Dent.Ass. 2000, Vol. 123, 76-9.
Salzberg R., Gianbonini S. and Maurizio M.: Double blind comparison of nimesulide and Mefenamic acid in the treatment of upper respiratory tract. Journal of Medicine. 2003, 81, 120-32.
Capella L., Guerra A. and Laudizi L.: Efficacy and tolerability of nimesulide in the treatment of inflammatory conditions of pediatric patients. European Journal of Clinical Pharmacology 27:1432- 41.
Pierleoni P., Tonelli P. and Scarricabarozi L.: A double blind comparison of nimesulide and voltaren in dental surgery. J. of Oral surgery. 2003, Vol.260, Issue 1:39-46.
Vello G.P.: The anti-inflammatory analgesic and antipyretic activity of nimesulide drugs. Int. J. Oral Surg. 2001, 79:69-73.
Bjornsson G.A. et al: Naproxin versus Ibuprofen: Effect on swelling and other acute postoperative events after bilateral third molar surgery. J. Oral Surgery. 2003, 61, 11-21.
Williams H.J., Ward J.R. & Egger M.J.: Comparison of naproxen and acetaminophen in two year study of treatment of osteoarthritis of the knee. BMJ. 2003, 74: 675-94.
Seymour R.A. & Walton J.R.: Pain control after third molar surgery. J. oral & Max. surgery. 2001, Vol. 71 65-74.
Pollman L.: Long term follow up of postoperative swelling. Journal of surgery. 2003, 81: 79-84.
Moller P.L.: Time to onset of analgesia and analgesic efficacy of nimesulide compared to naproxen in postoperative dental pain. Journal of cardiovascular pharmacology. 2000, Vol.78, 125-41.
Scott L.J., H.M. Lamb, and Scolaries G.: A comparison of nimesulide and naproxen in postoperative dental pain. International Endodontic Journal. 1999, 36:85-92.
Began J.V. and Anderson K.: Clinical comparison of nimesulide versus naproxen in postoperative dental pain. British Journal of Clinical Pharmacology. 2005, 42: 209-14.
Mmeyer R.A., Campbell J.N. and Raja S.N.: Peripheral neural mechanisms of nociception. The Journal of neurosciences. 1998, Vol.76, 45-7.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2013 Dilman Najmaddin Muhammad, Reiadh K. Al-Kamali, Ahmed A. Haider (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The copyright on any article published in Zanco J Med Sci is retained by the author(s) in agreement with the Creative Commons Attribution Non-Commercial ShareAlike License (CC BY-NC-SA 4.0).
