Serum magnesium levels during pregnancy and their correlation with maternal demographic characteristics: A cross-sectional study

Rose Burhanedin Meerany
Department of Obstetrics and Gynecology, College of Medicine, Hawler Medical University, Erbil, Kurdistan Region, Iraq.
Shayma Abd Ezat
Department of Obstetrics and Gynecology, College of Medicine, Hawler Medical University, Erbil, Kurdistan Region, Iraq.
Shelan Omer Jaafar
Department of Obstetrics and Gynecology, College of Medicine, Hawler Medical University, Erbil, Kurdistan Region, Iraq.
Nazar P. Shabila
Catholic University in Erbil, Erbil, Kurdistan Region, Iraq.
Shahla Kareem Alalaf
Department of Obstetrics and Gynecology, College of Medicine, Hawler Medical University, Erbil, Kurdistan Region, Iraq.
Share:

Abstract

Background and objective: The rate of low magnesium levels in pregnancy varies significantly between regions, shaped by dietary practices, socioeconomic factors, and healthcare access. This study aimed to determine the prevalence of hypomagnesaemia in pregnant women attending a tertiary public hospital and any maternal associated factor in relation to magnesium levels.

Methods: A cross-sectional study was conducted on 930 pregnant women across all trimesters at Maternity Teaching Hospital, Erbil, Kurdistan Region, Iraq, from 3rd January 2023 to 3rd January 2024. Serum magnesium concentrations (mg/dL) were determined using the Cobas Integra analyzer. These levels were correlated with demographic characteristics and weight.

Results: The mean serum magnesium level was 1.86±0.22 mg/dL (median 1.88, range 0.47-2.7 mg/dL). Hypomagnesemia was observed in 4.3% (n=40) and hypermagnesemia in 3.3% of participants. Serum magnesium levels showed a trend towards decreasing with advancing gestational age, although differences between trimesters were statistically significant. No significant association was found between hypomagnesemia and educational level or occupation.

Conclusion: Hypomagnesemia was infrequent in pregnant women at the studied hospital and was not linked to education, socioeconomic status, or body weight.

Metrics

Metrics Loading ...

References

  1. Fritzen R, Davies A, Veenhuizen M, Campbell M, Pitt SJ, Ajjan RA, et al. Magnesium deficiency and cardiometabolic disease. Nutrients. 2023;15(10):2355. doi:10.3390/nu15102355.
  2. Ismail AAA, Ismail NA. Magnesium: A mineral essential for health yet generally underestimated or even ignored. J Nutr Food Sci. 2016;6(4):1000523. doi:10.4172/2155-9600.1000523.
  3. Yee J. Magnesium: An important orphan. Adv Chronic Kidney Dis. 2018;25(3):217–21. doi:10.1053/j.ackd.2018.04.001.
  4. Fanos D, Gerosa C, Nurchi VM, Manchia M, Saba L, Coghe F, et al. The role of magnesium in pregnancy and in fetal programming of adult diseases. Biol Trace Elem Res. 2021;199:3647–57. doi:10.1007/s12011-020-02433-2.
  5. Workinger JL, Doyle RP, Bortz J. Challenges in the diagnosis of magnesium status. Nutrients. 2018;10(9):1202. doi:10.3390/nu10091202.
  6. Crowther CA, Ashwood P, Middleton PF, Bain E, Tran T, Roberts CT, et al. Prenatal intravenous magnesium at 30–34 weeks’ gestation and neurodevelopmental outcomes in offspring: The MAGENTA randomized clinical trial. JAMA. 2023;330(7):603–14. doi:10.1001/jama.2023.12357.7-
  7. Spätling L, Classen HG, Kisters K, Liebscher U, Rylander R, Vierling W, et al. Supplementationof magnesium in pregnancy. J Pregnancy Child Health. 2017;4:302. doi: 10.4172/2376-127X.1000302.
  8. Wiles K, Chappell L, Clark K, Elman L, Hall M, Lightstone L, et al. Clinical practice guideline on pregnancy and renal disease. BMC Nephrol. 2019;20(1):401. doi:10.1186/s12882-019-1560-2.
  9. Zarean E, Tarjan A. Effect of magnesium supplement on pregnancy outcomes: A randomized control trial. Adv Biomed Res. 2017;6:109. doi:10.4103/2277-9175.213879.
  10. Zarean E, Tarjan A. Effect of magnesium supplement on pregnancy outcomes: A randomized control trial. Adv Biomed Res. 2017;6:109. doi:10.4103/2277-9175.213879.
  11. Naowar M, Dickton D, Franci J. Cardiometabolic risk factors associated with magnesium and vitamin D nutrients during pregnancy—A narrative review. Nutrients. 2024;16:2630. doi:10.3390/nu16162630.
  12. de Araújo CAL, de Sousa Oliveira L, de Gusmão IMB, de Almeida RM, Rocha LOC, Amorim MMR, et al. Magnesium supplementation and preeclampsia in low-income pregnant women - a randomized double-blind clinical trial. BMC Pregnancy Childbirth. 2020;20:208. doi:10.1186/s12884-020-02877-0
  13. Venkatesan S, Mallika A. A comparative study between maternal serum magnesium levels in preterm & term labour. Int J Clin Obstet Gynaecol. 2023;7(1):177–9. doi:10.33545/gynae.2023.v7.i1c.1273
  14. Malathi T, Maddipati SS. A comparative study of serum magnesium levels in preterm labour and term labour. Int J Reprod Contracept Obstet Gynecol. 2020;9:3291–6. DOI: https://doi.org/10.18203/2320-1770.ijrcog20203311
  15. Enaruna NO, Ande ABA, Okpere EE. Clinical significance of low serum magnesium in pregnant women attending the University of Benin Teaching Hospital. Niger J Clin Pract. 2013;16(4):448–53. doi:10.4103/1119-3077.116887.
  16. Larsson A, Palm M, Hansson LO, Basu S, Axelsson O. Reference values for clinical chemistry tests during normal pregnancy. BJOG. 2008;115(7):874–81. doi:10.1111/j.1471-0528.2008.01709.x.
  17. Orlova S, Dikke G, Pickering G, Yaltseva N, Konchits S, Starostin K, et al. Risk factors and comorbidities associated with magnesium deficiency in pregnant women and women with hormone-related conditions: Analysis of a large real-world dataset. BMC Pregnancy and Childbirth. 2021; 22;21(1):76. doi: 10.1186/s12884-021-03558-2
  18. Yefet E, Braester Y, Marchenko E, Nachum Z. Association between serum-magnesium concentrations, maternal features and neonatal outcomes in women with preeclampsia/eclampsia treated with magnesium-sulfate. AJOG. 2020;222(1):S335-S336. https://www.ajog.org/article/S0002-9378(19)31905-2/abstract
  19. Orlova S, Dikke G, Pickering G, Yaltseva N, Konchits S, Starostin K, et al. Risk factors and comorbidities associated with magnesium deficiency in pregnant women and women with hormone-related conditions: analysis of a large real-world dataset. BMC Pregnancy and Childbirth. 2021;21(76). https://doi.org/10.1186/s12884-021-03558-2
  20. ZHAO B, ZENG L, ZHAO J, WU Q, DONG Y, ZOU F, et al. Association of magnesium intake with type 2 diabetes and total stroke: an updated systematic review and meta-analysis. BMJ open. 2020;10(3):e032240. doi: 10.1136/bmjopen-2019-032240.
  21. Anand S, Jaggi R, Bala N. Serum magnesium levels in preterm labour in relation to socio-economic status. Int J Reprod Contracept Obstet Gynecol. 2022;11(2):552–6. doi:10.18203/2320-1770.ijrcog20220068.
  22. Ibikunle HA, Okafor IP, Adejimi AA. Pre-natal nutrition education: Health care providers’ knowledge and quality of services in primary health care centres in Lagos, Nigeria. PloS one 2021;16(11):e0259237. https://doi.org/10.1371/journal.pone.0259237
  23. Zarean E, Tarjan A. Effect of magnesium supplement on pregnancy outcomes: a randomized control trial. Adv Biomed Res. 2017;6:109. doi: 10.4103/2277-9175.213879.
How to Cite
Burhanedin Meerany, R. ., Abd Ezat, S., Omer Jaafar, S. ., P. Shabila, N., & Kareem Alalaf, S. . (2026). Serum magnesium levels during pregnancy and their correlation with maternal demographic characteristics: A cross-sectional study. Zanco Journal of Medical Sciences (ZJMS), 30(2), 511–520. https://doi.org/10.15218/zjms.2026.035

Send mail to Author


Send Cancel