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The role of high-sensitivity C-reactive protein in patients presenting with acute coronary syndrome at Erbil cardiac center

Noor Najat Haji
Department of Clinical Biochemistry, College of Health Science, Hawler Medical University, Erbil, Kurdistan Region, Iraq.
Kamaran Younis M. Amin
Department of Chemistry, College of Education, Salahaddin University, Erbil, Kurdistan Reign, Iraq.
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Abstract

Background and objective: Acute coronary syndrome (ACS) is the predominant cardiovascular disease cause of death. One of the newer criteria for assessing acute coronary syndromes (ACS) is serum high-sensitive C-reactive protein (hs-CRP), which has demonstrated predictive value for coronary artery conditions independently of conventional cardiovascular risk factors. This study aimed to evaluate and assess the correlation between highly sensitive C-reactive protein (hs-CRP) and the severity of acute coronary syndrome subtypes.

Methods: This cross-sectional study was performed on 180 patients diagnosed with ACS at the Surgical Specialty Hospital-Cardiac Center in Erbil, Iraq. Subjects were classified into three groups according to the types of ACS: Group I (STEMI patients-83 individuals), Group II (NSTEMI patients-74 individuals), and Group III (UA patients-23 individuals). Parameters of high-sensitivity C-reactive protein (hs-CRP), cardiac biomarkers, and lipid profile were evaluated for all patients.

Results: The study population consisted of 74.4% males and 25.6% females, aged 30 to 90 years, with a mean age of 58.66±12.03 years. Among all patients, 66.1% had hyperlipidemia, 58.3% had hypertension, 40% had diabetes, and 67.2% were smokers. Patients with myocardial infarction (STEMI and NSTEMI) had significantly higher levels of hs CRP (P = 0.026), troponin T hs (P <0.001), and CK-MB (P = 0.044) compared to UA patients. There was also found a positive significant correlation between serum hs-CRP with total cholesterol, LDL-C, and troponin T hs among ACS patients with statistically significant (r=0.171, P = 0.022), (r=0.202, P = 0.007), and (r=0.229, P = 0.002), respectively.

Conclusions: The current study shows that serum hs-CRP could serve as a useful biomarker for assessing disease severity in ACS patients.

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How to Cite
Najat Haji, N. ., & Younis M. Amin, K. . (2025). The role of high-sensitivity C-reactive protein in patients presenting with acute coronary syndrome at Erbil cardiac center. Zanco Journal of Medical Sciences (Zanco J Med Sci), 29(3), 753–764. https://doi.org/10.15218/zjms.2025.079

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