Gross placental anomalies and their association with newborn outcomes: A cross-sectional study

Sana Kamal Khidr
Department of Pathology and Anatomy, College of Medicine, Hawler Medical University, Erbil, Kurdistan region, Iraq.
Gzng Kakil Aziz
Department of Obstetrics and Gynecology, College of Medicine, Hawler Medical University, Erbil, Kurdistan region, Iraq.
Avin Saleem Husein
Department of Obstetrics and Gynecology, College of Medicine, Hawler Medical University, Erbil, Kurdistan region, Iraq.
Shahla kareem Al alaf
Department of Obstetrics and Gynecology, College of Medicine, Hawler Medical University, Erbil, Kurdistan region, Iraq.
Namir Altawil
Department of Community Medicine, College of Medicine, Hawler Medical University, Erbil, Kurdistan region, Iraq.
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Abstract

Background and objective: Correlating gross placentas abnormalities with perinatal outcomes is crucial for understanding their clinical impact. The aim of this study was to determine the prevalence of gross placentas anomalies within a sample of Kurdish women after delivery and subsequently assess the association between these anomalies with early neonatal outcomes.

Methods: A cross-sectional study was conducted at the labor ward of Maternity Teaching Hospital, Erbil city, Kurdistan region, Iraq between 15th of August 2023, and 14th of August 2024 on 500 freshly delivered placentas from term newborns. Placentas morphological and structural anomalies were identified and correlated with maternal demographic and early neonatal outcomes.

Placental morphological anomalies (weight, diameter, and thickness) were linked to maternal preeclampsia, diabetes, hypothyroidism, and anemia. Gross anomalies significantly impacted early neonatal outcomes (Apgar scores, birth weight, NICU admission, neonatal deaths).

Conclusion: A significant placental abnormalities are common and strongly correlated with adverse neonatal outcomes, particularly when maternal medical disorders are present. Therefore placental assessment is vital for predicting and preventing these outcomes.

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References

  1. Cindrova-Davies T, Sferruzzi-Perri AN. Human placental development and function. Semin. Cell Dev Biol. 2022; 131:66-7. https://doi.org/10.1016/j.semcdb.2022.03.039.
  2. Roberts D, Baergen RN, Boyd TK, Carreon Ch, Duncan V, Ernst L, et al .Criteria for placental examination for obstetrical and neonatal providers baby. Am J Obstet Gynecol. 2023:497-507. doi.org/10.1016/j.ajog.2022.12.017
  3. Nair BT, Raju U. Study of Correlation of Neonatal Outcomes with Gross Abnormalities of Placenta and Umbilical Cord. J Nepal Paediatr Soc. 2017; 37(3):254-60.
  4. Roberts DR. Gross examination of the placenta. https://www.uptodate.com/contents/gross-examination-of-the-placenta. (Accessed: February 2025).
  5. Roberts DJ, Baergen RN, Boyd TK, Carreon CK, Duncan VE, Ernst LM, et al. Criteria for placental examination for obstetrical and neonatal providers. Am J Obstet Gynecol. 2023; 228(5):497-508.e4. doi: 10.1016/j.ajog.2022.12.017.
  6. Awuah SP, Okai I, Ntim EA, Bedu-Addo K . Prevalence, placenta development, and perinatal outcomes of women with hypertensive disorders of pregnancy at Komfo Anokye Teaching Hospital. PLoS ONE. 2020; 15(10):e0233817. https://doi.org/10.1371/journal.pone.0233817
  7. Ehlers E, Talton O, DaSchust D, Schulz L. Placental structural abnormalities in gestational diabetes and when they develop: A scoping review. Placenta. 2021; 116:58-66. https://doi.org/10.1016/j.placenta.2021.04.005.
  8. Thompson, B.B., Holzer, P.H. & Kliman, H.J. Placental Pathology Findings in Unexplained Pregnancy Losses. Reprod Sci. 2024; 31:488–504. https://doi.org/10.1007/s43032-023-01344-3
  9. Horikoshi Y, Yaguchi C, Furuta-Isomura N, Itoh T, Kawai K, Oda T, et al. Gross appearance of the fetal membrane on the placental surface is associated with histological chorioamnionitis and neonatal respiratory disorders. PLoS One. 2020; 15(11):e0242579. doi: 10.1371/journal.pone.0242579.
  10. Early pregnancy loss. Practice Bulletin No. 150. Obstet Gynecol. 2015; 125:1258–67. DOI: 10.1097/01.AOG.0000465191.27155.25
  11. Lim JU, Lee JH , Kim JS , Hwang YI , Kim T , Lim SY , et al. Comparison of World Health Organization and Asia-Pacific body mass index classifications in COPD patients. Int J Chron Obstruct Pulmon Dis. 2017; (2017)12:2465-75. DOI https://doi.org/10.2147/COPD.S141295.
  12. Rathbun K, Hildebrand J. Placenta Abnormalities. https://www.ncbi.nlm.nih.gov/books/NBK459355/. (Accessed: March 2, 2025).
  13. Sadaf Z, Mariam M , Sherif O, Tracy JR, Joseph R.S , Puneet B, et al. Comprehensive Imaging Review of Abnormalities of the Placenta. Ultrasound Q. 2016; 32(1):25-42. DOI: 10.1097/RUQ.0000000000000157
  14. Rathbun KM, Hildebrand JP. Placenta Abnormalities .StatPearls (Last Update: October 17, 2022) [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK459355/. (Accessed: May 24, 2025)
  15. Vrabie SC, Novac L, Manolea MM, Dijmarescu LA, Novac M Siminel MA. Abnormalities of the Umbilical Cord. https://www.intechopen.com/news. (Accessed: May 20, 2025).
  16. Kowalski PJ. Thin cord. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/placentathincord.html. (Accessed: April 3rd, 2025).
  17. Lai Sh, Flatley Ch, Kumar S. Perinatal risk factors for low and moderate five-minute Apgar scores at term. Eur J Obstet Gynecol Reprod Biol. 2017; 210:251-56. https://doi.org/10.1016/j.ejogrb.2017.01.008.
  18. Marete I, Ekhaguere O, Bann CM, Hibberd PL, Sarah PH,SaleemS,etal.Regional trends in birth weight in low- and middle-income countries 2013–2018. Reprod Health. 2020; 17(Suppl 3):176. https://doi.org/10.1186/s12978-020-01026-2
  19. Jaiman, S. Gross Examination of the Placenta and Its Importance in Evaluating an Unexplained Intrauterine Fetal Demise. J Fetal Med. 2015; 2:113–20. https://doi.org/10.1007/s40556-015-0060-0
  20. Matsuzaki S, Ueda Y, Matsuzaki S, Sakaguchi H, Kakuda M, Lee M, et al. Biomedicines 2023; 11(6):1522. https://doi.org/10.3390/biomedicines11061522
  21. Griffiths S, Campbell J Placental structure, function and drug transfer. BJA Education. 2015; 15(2):84-9. https://doi.org/10.1093/bjaceaccp/mku013
  22. Bukowski R, Hansen NI, Pinar H, Willinger M, Reddy UM, Parker CB , et al. Altered fetal growth, placental abnormalities, and stillbirth. PLoS ONE. 2017; 12(8):e0182874. https://doi.org/10.1371/journal.pone.0182874
  23. Khajuria RSM. Histopathology of placenta in intrauterine growth restriction (IUGR). Int J Research Med. 2019; 7(3):889-92. doi:10.18203/2320-6012.ijrms20190943
  24. Falco ML, Sivanathan J, Laoreti A, Thilaganathan B, Khalil A. Placental histopathology associated with pre-eclampsia: systematic review and meta-analysis. UOG. 2017; 50(3):295-301. https://doi.org/10.1002/uog.17494
  25. Kapustin R.V, Kopteyeva E.V, Tral T.G., Tolibova G.K. Placental morphology in different types of diabetes mellitus. J Obstet Women's Dis. 2021; 70(2):13-26. https://doi.org/10.17816/JOWD57149
  26. Garg P, Saxena D, Mangal K. Maternal Hypothyroidism and Its Effect on Placenta and Newborn: A Morphometric and Histopathological Study. Int J Health Res. 2021; 4(13):130-4.
  27. Kavya NK, Kugananthan, M, Ramakrishnan, S. The study of morphology of placenta in anaemic subjects in south Indians. Int J Health Sci. 2022; 6(S7):1994–2001. https://doi.org/10.53730/ijhs.v6nS7.11738
  28. Cindrova-Davies T, Sferruzzi-Perri A. Human placental development and function Semin. Cell Biol. 2022; 131(66):66-77. doi: 10.1016/j.semcdb.2022.03.039
  29. Kavya NK, Kugananthan, M, Ramakrishnan, S. The study of morphology of placenta in anaemic subjects in south Indians. Int J Health Sci. 2022; 6(S7):1994–2001. https://doi.org/10.53730/ijhs.v6nS7.11738
  30. Cindrova-Davies T, Sferruzzi-Perri A. Human placental development and function Semin. Cell Biol. 2022; 131(66):66-77. https://doi.org/10.1016/j.semcdb.2022.03.039
How to Cite
Khidr, S., Kakil , G., saleem Husein , A., Al alaf, S. ., & Altawil, N. (2025). Gross placental anomalies and their association with newborn outcomes: A cross-sectional study. Zanco Journal of Medical Sciences (Zanco J Med Sci), 29(2), 361–371. https://doi.org/10.15218/zjms.2025.038

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