Copyright (c) 2025 Khoshawi Mousa khaleel, Saeed Ghulam Hussain (Author)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
- Articles
- Submited: December 10, 2024
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Published: October 22, 2025
Abstract
Background and objectives: Thyroid diseases are worldwide endocrine disorders in clinical practice. Risk prevalence is higher in females than males with significant clinical adverse effects among these cardiovascular diseases. Prevalence is high among diabetic patients; with subclinical hypothyroidism categorized as the most common endocrine disorders. The aim of the present study was to screen the prevalence of thyroid dysfunction among apparently healthy adults, with special reference to diabetic patients.
Methods: 300 apparently healthy adults’ thyroid free disorders were screened included 200 females &100 males individuals of different age & BMI. Blood samples were collected & subjected to. thyroid profiles test included TSH, FT3 &FT4.Thyroid dysfunction-were further categorized according to the tested thyroid profiles.
Results: The results revealed 7.3 % prevalence of sub-clinical hypothyroidism followed by overt hypothyroidism (1.7%) & subclinical hyperthyroidism (0.7%). Among diabetic patients subclinical hypothyroidism predominate (12.5%) followed by clinical hypothyroidism (7.5%).
Conclusion: The results delineated the fact that among thyroid free subjected, screening in of paramount importance especially diagnosis of subclinical hypothyroidism that might linked with significant clinical complication especially female during pregnancy & as a cardiovascular diseases risk factor.
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References
- Zhang X, Wang X, Hu H, Qu H, Xu Y, Li Q. Prevalence and trends of thyroid disease among adults. Endocr Pract. 2023; 49(11):875-80. https://doi.org/10.1016/j.eprac.2023.08.006
- Lancet T. Thyroid disease-more research needed. The Lancet. 2012; 379(9821):1076. https://doi.org/10.1016/s0140-6736(12)60445-0
- Taylor P.N., Albrecht D, Scholz A, Gutierrez- Buey G, Lazarus J.H, Dayan C, et al. Global epidemiology of hyperthyroidism & hyperthyroidism. Nat Rev Endocrinol. 2018; 14(5):301-16. https://doi:10.1038/nrendo.2018.18.
- Fisher S.B, Perrier N.D. The incidental thyroid nodule.CA: A cancer Journal for clinical. 2018; 68(2):97-105. https://doi:10.3322/caac.21447
- Wang X, Mo Z , Mao G , Zhu W , Xingn M , Li X, et al. Geographical influences on thyroid abnormalities in adult population from iodine -regions: across- sectional study. Scientific reports. 2021; 11(1); 994. https://doi:1038/s41598-020-80248-710.
- Mendoza A, Hollenberg A N. New insights into thyroid hormone action. Pharmacology & therapeutics. 2017; 173:135-45. DOI: 10.1016/j.pharmthera.2017.02.012
- Leitch V D, Bassett J H D, Williams G R. Role of thyroid hormones in craniofacial development. Nat Rev Endocrinol. 2020; 16(3):147-64. DOI: 10.1038/s41574-019-0304-5
- Vucic S, Korevaar T.I.M, Dhamo B, Jaddoe V.W.V, Peeters R.P, Wolvius E.B, et al. Thyroid function during early life and dental development. Journal of dental research. 2017;96(9):97-105. https://doi.org/10.1177/0022034517708551.
- Ferrari S.M, Fallahi P, Elia G, Ragusa F, Ruffilli I, Paparo S.R, Antonelli A. Thyroid autoimmune disorders and cancer. Seminars in cancer biology.2020;64:135-146. DOI: 10.1016/j.semcancer.2019.05.019
- Biondi B, Kahaly G.J, Robertson R.P. Thyroid dysfunction and diabetes mellitus: two closely associated disorders. Endocr Rev. 2019; 40(3):789-824. DOI: 10.1210/er.2018-00163
- Kwon M, Jeong YJ, Kwak J, Jung KY, Baek SK. Association between oral health and thyroid disorders: population-based cross-section study. Oral Dis. 2022; 28(8):2277-2284. https://doi.org/10.1111/odi.13895
- Floriani C, Gencer B, Collet T H, Rodondi N, Subclinical thyroid dysfunction and cardiovascular disease:2016 update. European heart journal. 2018; 39(7):503-7. https://doi.org/10.1093/eurheartj/ehx050
- Tang R, Wang J, Yang L, Ding X, Zhong Y, Pan J, et al. Subclinical hypothyroidism and depression: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2019; 10:1-10. https://doi.org/10.3389/fendo.2019.00340
- Moon S, Kim MJ, Yu JM, Yoo H J., Park YJ. Subclinical hypothyroidism and the risk of cardiovascular disease and all-cause mortality: a meta-analysis of prospective Cohort Studies. Thyroid. 2018; 28(9):1101-10. https://doi.org/10.1089/thy.2017.0414
- Delitala AP. Subclinical hyperthyroidism and the cardiovascular disease. Hormone and Metabolic Research. 2017; 49(10):723-31. DOI: 10.1055/s-0043-117893
- Ballou S, Katon J, Singh P, Rangan V, Lee H.N, McMahon C, et al. Chronic diarrhea and constipation are more common in depressed individuals. Clinical Gastroenterology and Hepatology. 2019; 17(13):2696-703. https://doi.org/10.1016/j.cgh.2019.03.046
- Aminorroaya A, Meamar R, Amini M, Feizi A, Tabatabae A, Faghih Imani E. Incidence of thyroid dysfunction in an Iranian adult population: the predictor role of thyroid autoantibodies: results from a prospective population-based cohort study. Eur J Med Res. 2017; 22(1):21. https://doi.org/10.1186/s40001-017-0260-2
- Rashad NM, Samir GM. Prevalence, risks, and comorbidity of thyroid dysfunction: a cross-sectional epidemiological study. Egypt J Intern Med. 2019; 31(4):635–41
- Kargar S, Tabatabaei SM, Okati-Aliabad H, Rad HI. Prevalence of Thyroid Dysfunction Disorders among Adult Populations in the Middle–East: A Systematic Review and Meta-analysis. The Open Public Health Journal. 2024; 17. DOI: 10.2174/0118749445317174240827052511
- Zaman B, Rasool SO, Sabri SM, Raouf GAM, Balatay AA, Abdulhamid MA et al. Prevalence of thyroid dysfunction in a large, unselected population in Duhok city, Iraq Kurdistan: A cross-sectional study. Journal of Biological Research-Bollettino Della Société. 2021; 92(2):1-9. https://doi.org/10.4081/jbr.2021.10067.
- Amouzegar A, Mehran L, Takyar M, Abdi H, Azizi F. Tehran thyroid study (TTS). Int J Endocrinol Metab. 2018; 16(4):1-6. https://doi.org/10.5812/ijem.84727
- Garmendia M. A, Santos P. S, Guillén-G. F, Galofré JC. The incidence and prevalence of thyroid dysfunction in Europe: a meta-analysis. J Clin Endocrinol Metab. 2014; 99(3):923-31. DOI: 10.1210/jc.2013-2409.
- Mehran L, Amouzegar A, Rahimabad PK, Tohidi M, Tahmasebinejad Z, Azizi F. Thyroid function and metabolic syndrome: a population-based thyroid study Hormone and Metabolic research. 2017; 49(3):192-200. https://doi.org/10.1055/s-0042-117279
- Ghaemmaghami Z, Firoozbakhsh P, Gholami D, Khodabandelu S, Baay M, Maleki M, et al. Increased prevalence of thyroid dysfunction in Tehran – HAMRAH study. BMC Endocr Disord. 2023; 23(1):270. https://doi.org/10.1186/s12902-023-01524-x
- Shahrokh E.S, Tabatabaee A, Aminorroaya A, Amini M, Feizi A, Janghorbani M, et al. Isfahan thyroid cohort study (ITCS). Hormone and Metabolic research, Arch Iran Med. 2021; 24(11):788–95. https://doi.org/10.34172/aim.2021.118
- Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid Cancer: the American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid Cancer. Thyroid. 2016; 26(1):1–133. https://doi.org/10.1089/thy.2015.0020
- Hussein SMM, AbdElmageed RM. The relationship between type 2 diabetes mellitus and related thyroid diseases. Cureus. 2021; 13(12):e20697. https://doi.org/10.7759/cureus.20697
- Kahaly GJ, Robertson RP. Thyroid Dysfunction and Diabetes Mellitus: Two Closely Associated Disorders. Endocr Rev. 2019; 40(3):789-824. https://doi.org/10.1210/er.2018-00163
- Nishi M, Diabetes mellitus and thyroid diseases. Diabetol Int. 2018; 9(2):108–112. https://doi.org/10.1007/s13340-018-0352-4
- Jali MV, S Kambar S, Jali SM, Pawar N, Nalawade P. Prevalence of thyroid dysfunction among type 2 diabetes mellitus patients. Diabetes & Metabolic. 2017; 11(1):105-108. https://doi.org/10.1016/j.dsx.2016.12.017
- Khassawneh AH, Al-Mistarehi AH ,Zein Alaabdin AM ,Khasawneh L ,AlQuran TM ,Kheirallah KA , et al. Prevalence and Predictors of Thyroid Dysfunction Among Type 2 Diabetic Patients: A Case–Control Study. Int J Gen Med. 2020; 13:803-16. https://doi.org/10.2147/IJGM.S273900
- Santini F, Marzullo P, Rotondi M, Ippolito S , Chiovato L , Biondi B et al. Mechanisms in endocrinology: the crosstalk between thyroid gland and adipose tissue: signal integration in health and disease. Eur J Endocrinol. 2014; 171(4):137-52. https://doi.org/10.1530/eje-14-0067