TY - JOUR AU - Bakir, Amin Aziz PY - 2021/12/23 Y2 - 2024/03/28 TI - Human papillomavirus and herpes simplex virus infections in patients with mucocutaneous lesions can be linked to host TBX-21 gene polymorphism JF - Zanco Journal of Medical Sciences (Zanco J Med Sci) JA - Zanco J Med Sci VL - 25 IS - 3 SE - Original Articles DO - 10.15218/zjms.2021.033 UR - https://zjms.hmu.edu.krd/index.php/zjms/article/view/757 SP - 666-674 AB - <p><strong>Background and objective</strong>: Human papillomavirus (HPV) and herpes simplex-2 (HSV-2) are the common cause of genital lesions in women. The variation in host genetic makeup can determine the consequence of a viral infection in that host. <em>T-bet</em> gene polymorphism has been associated with the incidence of several types of infections. This study investigates the impact of <em>T-bet</em> polymorphism on the incidence of HPV and HSV in genital lesions.</p><p><strong>Methods</strong>: 215 women, including 71 HPV infected, 72 HSV-2 infected, and 72 controls were enrolled. Viral genotyping was done on genital swab samples using Realtime PCR. In all participants, the extracted DNA from blood was tested for <em>T-bet</em> gene variation at Ch17.rs17244587 G&gt;A site using ARMS-PCR. ELISA was done to participants sera to detect HSV-1 IgM.</p><p><strong>Results</strong>: Genotyping of HPV infection revealed that (73.0%) were at low risk. Most individuals (72.5%) were homozygous GG, while (20.9%) were heterozygous AG and (6.5%) were homozygous AA, of which 92.8% were HSV-2 infected patients. None of 18 (8.4%) HSV-1-IgM positive women were homozygous AA.</p><p><strong>Conclusion</strong>: <em>T-bet</em> gene allele A appears to be linked with more incidence of HSV-2 in genital lesions, but such influence was not observed for HPV genotypes and HSV-1.</p> ER -