TY - JOUR AU - Al-Nimer, Marwan S.M. AU - Dezayee, Zhian M.I. PY - 2017/12/01 Y2 - 2024/03/29 TI - Measurements of serum high sensitivity-C reactive protein, and procalcitonin levels in type1 and 2 Diabetes complicated with diabetic foot syndrome JF - Zanco Journal of Medical Sciences (Zanco J Med Sci) JA - Zanco J Med Sci VL - 21 IS - 3 SE - Original Articles DO - 10.15218/zjms.2017.045 UR - https://zjms.hmu.edu.krd/index.php/zjms/article/view/53 SP - 1869 - 1877 AB - <p><strong>Background and objective: </strong>There is evidence that the procalcitonin levels are usually correlated with the high sensitivity C-reactive protein levels in inflammatory conditions. Therefore, this study aimed to assess the simultaneous changes of the procalcitonin and hs-CRP levels in the diabetic foot syndrome complicated type 1 and 2 diabetes.</p><p><strong>Method: </strong>This observational study was carried in the Center of Diabetes Mellitus in Erbil, Iraq from 1<sup>st</sup> January to the 30<sup>th</sup> September 2015. A total number of 170 participants were enrolled in this study. They grouped into Group I (healthy subjects, n=30), Group II (type 1 diabetes with diabetic foot syndrome, n=70) and Group III (type 2 diabetes with diabetic foot syndrome, n=70). The anthropometric measurements, blood pressure, fasting serum glucose and lipid profile, and the inflammatory markers included high sensitivity C-reactive protein and procalcitonin were determined.</p><p><strong>Results: </strong>Group III patients had a significant longer duration and score of diabetic foot syndrome,&nbsp;higher anthropometric measurements, higher blood pressure and fasting lipid profile levels compared with Group II. Serum procalcitonin and high sensitivity C-reactive protein levels were significantly higher in diabetic patients compared with Group I subjects. The serum levels of procalcitonin and high sensitivity C-reactive protein of Group III patients (1.11±0.47 ng/ml; 12.48±2.57 mg/L) were significantly higher than corresponding values of Group II patients (0.334±0.094 ng/ml; 5.73±0.89 mg/L). A non-significant correlation between procalcitonin with high sensitivity C-reactive protein in Group II and III was observed.</p><p><strong>Conclusion: </strong>We conclude that the simultaneous measurements of high sensitivity C-reactive protein and procalcitonin as inflammatory biomarkers are not necessary because the correlation was not significant.</p> ER -