TY - JOUR AU - Al-Barzinji, Rukia M. PY - 2010/04/01 Y2 - 2024/03/28 TI - Estimation of Interleukin-8 Level in Diarrheic Children Infected with Rotavirus JF - Zanco Journal of Medical Sciences (Zanco J Med Sci) JA - Zanco J Med Sci VL - 14 IS - 1 SE - Original Articles DO - 10.15218/zjms.2010.005 UR - https://zjms.hmu.edu.krd/index.php/zjms/article/view/494 SP - 28 - 34 AB - <p><strong>Background and objective</strong>: Rotavirus is the most important cause of severe diarrhea in children worldwide. We have investigated that certain cytokines especially interleukin- 8 (IL-8) as a chemokine, may play an important role in the pathogenesis of and the protection against rotavirus disease in children. The purpose of this study was to reveal the association between IL-8 and child diarrhea with rotavirus.</p><p><strong>Methods:</strong> Stool samples were collected from 150 children under 5 years of age who developed diarrhea and 45 from non-diarrheic children of equivalent age. All samples were detected for rotavirus and serum IL-8 level. The study was undertaken from May to December of 2006. Enzyme linked immunosorbant assay (ELISA) was applied for detection rotavirus and IL-8.</p><p><strong>Results:</strong> Among the children, female patients with breast feeding were less infected with rotavirus compared to males with artificial and mixed feeding. The IL-8 concentration was highly significantly between the study groups (<em>P</em>&lt; 0.01). Regarding the gender, serum IL-8 level was significantly higher in males than females (<em>P</em>&lt;0.05). However, no significance prevalence in IL-8 level was recorded between gender in healthy control group (<em>P</em> &gt;0.05).</p><p><strong>Conclusion:</strong> Rotavirus infection induces the expression of chemokines as IL-8. These data support the hypothesis that chemokine secretion may play a role in the initiation and modulation of the immune response to rotavirus infection.</p> ER -