TY - JOUR AU - Al-kuraishy, Hayder M. AU - Al-Mgoter, Basim S. N. AU - A. Al-Gareeb, Ali Ismai PY - 2013/12/01 Y2 - 2024/03/29 TI - Dual effects of aspirin and Garcinia Cambogia on human blood viscosity JF - Zanco Journal of Medical Sciences (Zanco J Med Sci) JA - Zanco J Med Sci VL - 17 IS - 3 SE - Original Articles DO - 10.15218/zjms.2013.0042 UR - https://zjms.hmu.edu.krd/index.php/zjms/article/view/353 SP - 514 - 517 AB - <p style="text-align: justify; text-justify: inter-ideograph;"><strong style="font-size: 12pt;"><span style="font-family: Arial;">Background and objective: </span></strong><span style="font-family: Arial; font-size: 12pt;">Prevention of bacterial adhesion is an attractive target for the development of new therapies in the prevention of bacterial infection. The aim of this study is to investigate the effects of pomegranate peel extract, vitamin C, combination of pomegranate peel extract and vitamin C &amp; gemifloxacin on adhesion of </span><span style="font-family: Arial; font-size: 12pt;"><em>E.coli</em> to uroepithelial cells.&nbsp;</span></p><p style="text-align: justify; text-justify: inter-ideograph;"><strong><span style="font-family: Arial; font-size: 12pt;">Methods: </span></strong><span style="font-family: Arial; font-size: 12pt;">This study was conducted in the Department of Pharmacology, college of Medicine, AL-Mustansirya </span><span style="font-family: Arial; font-size: 12pt;">University</span><span style="font-family: Arial; font-size: 12pt;"> in</span><span style="font-family: Arial; font-size: 12pt;"> 2009. Twenty patients with peripheral vascular diseases enrolled in this study. Those patients randomly allocated equally into two groups; group (A) received aspirin oral tablets 300 mg/day and group (B) received aspirin oral tablets 300 mg/day plus </span><span style="font-family: Arial; font-size: 12pt;"><em>Garcinia cambogia</em> oral tablets 500mg/day. The duration of therapy was two weeks. In this study, measurements were done for total blood viscosity, packed cell volume, serum fibrinogen, and serum cholesterol, before treatment as control and after one and two weeks of treatment.</span></p><p style="text-align: justify; text-justify: inter-ideograph;"><strong><span style="font-family: Arial; font-size: 12pt;">Results: </span></strong><span style="font-family: Arial; font-size: 12pt;">A</span><span style="font-family: Arial; font-size: 12pt;">fter 2 weeks treatment with aspirin there was significant reduction in plasma fibrinogen (</span><span style="font-family: Arial; font-size: 12pt;"><em>p</em> &lt; 0.05). Combined aspirin and <em>Garcinia Cambogica</em> treatment for 2 weeks produce significant reduction in all blood viscosity parameters (<em>p</em>&lt;0.05) except the packed cell volume which was not affected (<em>p </em>&gt;0.05).</span></p><p style="margin-right: -4.5pt; text-align: justify; text-justify: inter-ideograph;"><strong><span style="font-family: Arial; font-size: 12pt;">Conclusion: </span></strong><span style="font-family: Arial; font-size: 12pt;">Aspirin and </span><span style="font-family: Arial; font-size: 12pt;"><em>Garcinia cambogia</em> produced significant and better effects than aspirin alone on blood viscosity.</span></p> ER -