TY - JOUR AU - Malla Ahmed, Nazlin Shakir AU - Sulaiman, Sherwan Rahman PY - 2016/12/15 Y2 - 2024/03/28 TI - Correlation between Endothelin-1 and oxidative stress in apparently healthy obese men JF - Zanco Journal of Medical Sciences (Zanco J Med Sci) JA - Zanco J Med Sci VL - 20 IS - 3 SE - Original Articles DO - 10.15218/zjms.2016.0052 UR - https://zjms.hmu.edu.krd/index.php/zjms/article/view/133 SP - 1513_1519 AB - <p style="text-align: justify; text-justify: inter-ideograph;"><strong><span style="font-family: 'Arial','sans-serif'; color: black; font-size: 12pt;">Background and objective: </span></strong><span style="font-family: 'Arial','sans-serif'; color: black; font-size: 12pt;">Obesity is the risk for many disease conditions and is becoming a global issue. Endothelial dysfunction and oxidative stress are linked to obesity. Endothelin-1 is a useful marker of endothelial dysfunction. Oxidative stress can be assessed by estimation of lipid peroxidation byproduct malondialdehyde. In this study, we tried to find out the correlation between Endothelin-1 and oxidative stress among apparently healthy obese men.</span><span style="font-family: 'Arial','sans-serif'; color: black;">&nbsp;</span></p><p style="text-align: justify; text-justify: inter-ideograph;"><strong><span style="font-family: 'Arial','sans-serif'; color: black; font-size: 12pt;">Methods: </span></strong><span style="font-family: 'Arial','sans-serif'; color: black; font-size: 12pt;">Eighty apparently healthy non-smoker adult men have participated in this study. Their age ranged between 18 and 50 years. Their serum Endothelin-1&nbsp;(ELISA), malondialdehyde and lipid parameters (biochemical assays) have been estimated.</span></p><p style="text-align: justify; text-justify: inter-ideograph;"><strong><span style="font-family: 'Arial','sans-serif'; color: black; font-size: 12pt;">Results: </span></strong><span style="font-family: 'Arial','sans-serif'; color: black; font-size: 12pt;">Subjects were divided into three groups: normal weight (n = 25), overweight (n = 34) and obese (n = 26) basing on their body mass index. The study shows that Endothelin-1 is significantly correlated with each of Malondialdehyde and body mass index (r = 0.262, P = 0.019; r = 0.65, P &lt;0.001 respectively). Malondialdehyde is also significantly positively correlated with BMI (r = 0.378, P = 0.001).</span></p><p style="text-align: justify; text-justify: inter-ideograph;"><strong><span style="font-family: 'Arial','sans-serif'; color: black; font-size: 12pt;">Conclusion: </span></strong><span style="font-family: 'Arial','sans-serif'; color: black; font-size: 12pt;">Endothelial dysfunction and oxidative stress coexist in obesity. But which of them precedes the other? Is still a question needs to be further studied</span></p> ER -