@article{Ahmed_Chalabi_2021, title={Effect of vitamin D supplementation on HbA1c level in a cohort of type 1 diabetic patients}, volume={25}, url={https://zjms.hmu.edu.krd/index.php/zjms/article/view/749}, DOI={10.15218/zjms.2021.031}, abstractNote={<p><strong>Background and objective</strong>: Glycemic control is essential to halt the progression of diabetic complications. Some studies previously showed the effect of vitamin D on pancreatic β-cell function and insulin secretion. This study aimed to assess the effect of vitamin D supplementation on HbA1c in patients with type 1 diabetes and vitamin D deficiency.</p> <p><strong>Methods</strong>: This prospective quasi-experimental study was conducted in Erbil city from 1<sup>st</sup> September to 1<sup>st</sup> December 2019. In this study, 76 patients attending Layla Qasim diabetic center were tested. Only 50 patients were recruited that had vitamin D deficiency (25OHD: <20) and were aged less than 18 years. They received vitamin D supplementation for 12 weeks. HbA1c and vitamin D level was measured before and after supplementation.</p> <p><strong>Results: </strong>Before vitamin D supplementation, the mean level of serum 25(OH)D among females (8.67 ± 2.56) was lower than males (14.31 ± 3.19). However, no association was found between the initial HbA1c level and gender. HbA1c level (mean = 8.24 ± 0.49) improved significantly after vitamin D supplementation to the level of 7.93 ± 0.67 (<em>P</em> = 0.032). There was a significant difference between groups of glycosylated hemoglobin levels of (first tertile<7.5%, second tertile 7.6%-9.9%, third tertile ≥10%) after 12 weeks of supplementation with vitamin D (<em>P </em><0.001).</p> <p><strong>Conclusion</strong>: Vitamin D supplementation in type 1 diabetic patients with vitamin D deficiency lead to significant improvement in HbA1c level.</p>}, number={3}, journal={Zanco Journal of Medical Sciences (Zanco J Med Sci)}, author={Ahmed, Mohammed Yaseen and Chalabi, Dlair A.K.}, year={2021}, month={Dec.}, pages={649–656} }