@article{Saeed_Jalal_2013, title={Immunohistochemical expression of p53 and p21 in gliomas: a clinicopathological study}, volume={17}, url={https://zjms.hmu.edu.krd/index.php/zjms/article/view/358}, DOI={10.15218/zjms.2013.0029}, abstractNote={<p style="text-align: justify; text-justify: inter-ideograph;"><strong style="font-size: 12pt;"><span style="font-family: Arial;">Background and objective:</span></strong><span style="font-family: Arial; font-size: 12pt;"> To evaluate p53 and p21 proteins over expression in gliomas and their relation to some clinico-pathological parameters. </span></p> <p style="text-align: justify; text-justify: inter-ideograph; text-kashida-space: 50%;"><strong><span style="font-family: Arial; font-size: 12pt;">Methods: </span></strong><span style="font-family: Arial; font-size: 12pt;">From September 2009 to July 2010, a formalin fixed, paraffin embedded blocks of 60 gliomas cases were collected in addition to 44 astrocytomas, 5 oligodendrogliomas, 2 oligoastrocytomas, and 9 ependymomas. These cases were evaluated by immunohistochemistry using streptavidin-biotin method. </span></p> <p style="text-align: justify; text-justify: inter-ideograph; text-kashida-space: 50%;"><strong><span style="font-family: Arial; font-size: 12pt;">Results:</span></strong><span style="font-family: Arial; font-size: 12pt;"> Overall, 53% of gliomas were positive for p53; these cases formed 66% of astrocytomas, 20% of oligodendrogliomas and 100% of oligoastrocytomas. In contrast to astrocytomas, all ependymoma cases were negative for p53 protein. There was a significant association of p53 expression with patient’s age and tumor site. On the other hand, p21 expression was positive in 25% of gliomas; they comprised 23% of astrocytomas, 40% of oligodendrogliomas, 50% of oligoastrocytomas and 22% of ependymomas. Both p53 and p21 expressions seemed to be raising from low to high grades astrocytoma but they did not reach level of significance. </span></p> <p style="text-align: justify; text-justify: inter-ideograph; text-kashida-space: 50%;"><strong><span style="font-family: Arial; font-size: 12pt;">Conclusion:</span></strong><span style="font-family: Arial; font-size: 12pt;"> The results of the present study suggest that p53 overexpression is common in gliomas and p21 expression is less common. There was a trend of both marker expressions increasing with higher grades. </span></p>}, number={2}, journal={Zanco Journal of Medical Sciences (Zanco J Med Sci)}, author={Saeed, Tara Muhammad Ali and Jalal, Jalal Ali}, year={2013}, month={Aug.}, pages={435–442} }