@article{Fatah_Waheda_Kok_2016, title={Detection of urinary lactoferrin as an indicator of urinary tract infection in girls}, volume={20}, url={https://zjms.hmu.edu.krd/index.php/zjms/article/view/120}, DOI={10.15218/zjms.2016.0048}, abstractNote={<p style="text-align: justify; text-justify: inter-ideograph;"><strong><span style="font-family: ’Arial’,’sans-serif’; color: black; font-size: 12pt;">Background and objective: </span></strong><span style="font-family: ’Arial’,’sans-serif’; color: black; font-size: 12pt;">Lactoferrin (LF) is an iron-binding protein that is related in structure to transferrin. It is considered to be a part of the in­nate immune system. This study aimed to </span><span style="font-family: ’Arial’,’sans-serif’; color: black; font-size: 12pt;">assess the role of urinary lactoferrin (LF) as an indicator for diagnosis of urinary tract infection among girls. </span></p> <p style="text-align: justify; text-justify: inter-ideograph;"><strong><span style="font-family: ’Arial’,’sans-serif’; color: black; font-size: 12pt;">Methods: </span></strong><span style="font-family: ’Arial’,’sans-serif’; color: black; font-size: 12pt;">This study was conducted on girls suffering from UTI. Urine samples were tested for Lactoferrin before and after two months of the treatment using ELISA technique.</span></p> <p style="text-align: justify; text-justify: inter-ideograph;"><strong><span style="font-family: ’Arial’,’sans-serif’; color: black; font-size: 12pt;">Results: </span></strong><span style="font-family: ’Arial’,’sans-serif’; color: black; font-size: 12pt;">Urine specimens were collected from 25 girls with mean age ± SD of 6 ± 3 years without UTI as a control group (C) and 25 girls with mean age ± SD of 5.3 ± 3.18 years diagnosed as suffering from UTI (T1) followed by a set of 25 specimens after two months (T2). The mean concentration of urinary LF ± SD was 670 ± 319 ng/ml in the specimens of control group whereas it was 1387 ± 509 in the specimens of girls with UTI during the infection (T1) and 885 ± 268 after two months (T2). The mean concentrations of urinary LF during the infection (T1) were significantly (P <0.001) increased compared with controls (C) and significantly (P = 0.003) decreased after two months (T2), that may refer to a role of urinary LF in UTI. There was no significant (P = 0.089) difference between the mean concentration of urinary LF after two months (T2) compared with controls (C) that may indicate to the normalization of LF concentration after the treatment </span><span style="font-family: ’Arial’,’sans-serif’; color: black; font-size: 12pt;">synchronously</span><span style="font-family: ’Arial’,’sans-serif’; color: black; font-size: 12pt;"> with disappearing of UTI symptoms and significantly reduction of positive urinalysis results. </span></p> <p style="text-align: justify; text-justify: inter-ideograph;"><strong><span style="font-family: ’Arial’,’sans-serif’; color: black; font-size: 12pt;">Conclusion: </span></strong><span style="font-family: ’Arial’,’sans-serif’; color: black; font-size: 12pt;">The results of this study indicate the elevation of urinary Lactoferrin (LF) in girls suffering from UTI and probably being a good indicator for diagnosis of UTI. </span></p>}, number={3}, journal={Zanco Journal of Medical Sciences (Zanco J Med Sci)}, author={Fatah, Mohammed Hassan and Waheda, Nabeel Elia and Kok, Dik J.}, year={2016}, month={Dec.}, pages={1485_1489} }