Prevalence of ocular pseudoexfoliation in type II diabetes mellitus
DOI:
https://doi.org/10.15218/zjms.2024.47Keywords:
Pseudoexfoliation, Diabetes, Retinopathy, GlaucomaAbstract
Background and objective: Pseudoexfoliation syndrome is a systemic disorder related to age mostly affects the anterior structures of the eye. It is characterized by increased production and accumulation of abnormal fibrillar material inextraocular and intraocular tissues. There was a variation in the prevalence of pseudoexfoliation syndrome in diabetic patients compared with non-diabetic patients. The aim of the study is to estimate the prevalence of pseudoexfoliation syndrome among diabetic patients in a sample of the Iraqi population and evaluate the impacting factor that affects this prevalence
Methods: A cross-sectional study was conducted in the Ophthalmology Department/ Erbil Teaching Hospital during the period from 1st of August 2021 to 31st of March 2022. A convenient sample of 100 patients with an age of ≥50 years old and who were diagnosed with type 2 diabetes were enrolled in the current study. The questionnaire included sociodemographic characteristics of the patients (age, gender, smoking, and alcohol state), past medical history and investigations (duration of diabetes mellitus and HbA1c), and the results of the ophthalmologic history and examination including intraocular pressure, presence of diabetic retinopathy, and the presence of pseudoexfoliation syndrome
Results: About 52% of the patients were aged 50-59 years, while 9% had an age of ≥70 years. The prevalence of pseudoexfoliation syndrome was 9%. While diabetic retinopathy was presented in 37%. The prevalence of glaucoma was 12%. There was a significant association between pseudoexfoliation syndrome incidence and increasing the age of the patients, the highest prevalence was among patients with ≥70 years (P = 0.001). The pseudoexfoliation syndrome was significantly associated with diabetic retinopathy, the presence of glaucoma, and diabetic duration (P-values were 0.001, 0.001, and 0.026, respectively). In addition, the mean intraocular pressure was significantly higher among those with pseudoexfoliation syndrome than patients without pseudoexfoliation syndrome (P = 0.001)
Conclusion: The prevalence of pseudoexfoliation syndrome in diabetic patients was 9%. The duration of diabetes, diabetic retinopathy, glaucoma, and the age of the participants significantly impacted the prevalence of pseudoexfoliation syndrome.
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References
Aydın Y, Yıldırım N, Yaz Y, Tekin N, İnal M, Şahin FM. Role of Oxidative Stress in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma. Turk J Ophthalmol 2019; 49(2):61–7. DOI: 10.4274/tjo.galenos.2018.10734
Schweitzer C. Pseudoexfoliation syndrome and pseudoexfoliation glaucoma. J Fr Ophtalmol 2018; 41(1):78–90. DOI: 10.1016/j.jfo.2017.09.003
Yuan Y, Schlötzer-Schrehardt U, Ritch R, Call M, Chu FB, Dong F, et al. Transient expression of Wnt5a elicits ocular features of pseudoexfoliation syndrome in mice. PLoS One 2019; 14(3):e0212569. DOI: 10.1371/journal.pone.0212569
Elhawy E, Kamthan G, Dong CQ, Danias J. Pseudoexfoliation syndrome, a systemic disorder with ocular manifestations. Hum Genomics 2012; 6(1):22. DOI: 10.1186/1479-7364-6-22
Andrikopoulos G, Alexopoulos D, Sotiris G. Pseudoexfoliation syndrome and cardiovascular diseases. World journal of cardiology 2014; 6:847–54. DOI: 10.4330/wjc.v6.i8.847
Plateroti P, Plateroti AM, Abdolrahimzadeh S, Scuderi G. Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma: A Review of the Literature with Updates on Surgical Management. J Ophthalmol 2015; 2015:370371. DOI: 10.1155/2015/370371
Plateroti P, Plateroti AM, Abdolrahimzadeh S, Scuderi G. Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma: A Review of the Literature with Updates on Surgical Management. J Ophthalmol 2015; 2015:370371. DOI: 10.1155/2015/370371
Ariga M, Nivean M, Utkarsha P. Pseudoexfoliation Syndrome. J Curr Glaucoma Pract 2013; 7(3):118–20. DOI: 10.5005/jp-journals-10008-1148
Erener S. Diabetes, infection risk and COVID-19. Molecular Metabolism 2020; 39:101044. DOI: 10.1016/j.molmet.2020.101044
Dal Canto E, Ceriello A, Rydén L, Ferrini M, Hansen TB, Schnell O, et al. Diabetes as a cardiovascular risk factor: an overview of global trends of macro and micro vascular complications. European journal of preventive cardiology 2019; 26(2_suppl):25–32. DOI: 10.1177/2047487319878371
Harding JL, Pavkov ME, Magliano DJ, Shaw JE, Gregg EW. Global trends in diabetes complications: a review of current evidence. Diabetologia 2019; 62(1):3–16. DOI: 10.1007/s00125-018-4711-2
Thakur SJ, Lone IA. A hospital based study of pseudoexfoliation in diabetic patients undergoing cataract surgery. JMS SKIMS 2021; 24(Suppl 1).
Shazly TA, Farrag AN, Kamel A, Al-Hussaini AK. Prevalence of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma in Upper Egypt. BMC Ophthalmology 2011; 11(1):18. DOI: 10.1186/1471-2415-11-18
Latif Amin D, Al-Zandi KMM. Diabetic retinopathy pattern among Kurdish diabetic patients in the Kurdistan region of Iraq. Revista Latinoamericana de Hipertensión 2019; 14(6):669–74.
Bhutia KL, Dhakal S, Bhutia SC. To find the prevalence of glaucoma in patients with diabetes mellitus attending tertiary care hospital, east Sikkim. Indian Journal of Clinical and Experimental Ophthalmology 2018; 4(4):447–9.
Zhou M, Wang W, Huang W, Zhang X. Diabetes mellitus as a risk factor for open-angle glaucoma: a systematic review and meta-analysis. PloS one 2014; 9(8):e102972. DOI: 10.1371/journal.pone.0102972
Špečkauskas M, Tamošiūnas A, Jašinskas V. Association of ocular pseudoexfoliation syndrome with ischaemic heart disease, arterial hypertension and diabetes mellitus. Acta ophthalmologica 2012; 90(6):e470–e5. DOI: 10.1111/j.1755-3768.2012.02439.x
Ubeid A. Prevalence of Pseudoexfoliation Syndrome in Erbil population: A hospital based study. Madridge Journal of Ophthalmology 2018; 3:33–5. DOI: 10.18689/mjop-1000110
Sherief ST, Kibru E, Shibeshe MA. Prevalence of Pseudoexfoliation among Adults and its Related Ophthalmic Variables in the Southern, Ethiopia: A Cross Sectional Study: Research Square; 2020.
Daldal H, Balikoglu Yilmaz M. Effects of the Presence of Pseudoexfoliation on Intraocular Pressure and Retinal Nerve Fiber Layer Thickness in Patients with Macular Degeneration Receiving Intravitreal Ranibizumab. Clinics and Practice 2022; 12(1):78–83. DOI: 10.3390/clinpract12010009
Gunes A, Yasar C, Tok L, Tok O. Prevalence of pseudoexfoliation syndrome in Turkish patients with senile cataract. Semin Ophthalmol 2017; 32(3):297–301. DOI: 10.3109/08820538.2015.1068344
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