Incidence and management of ureteric stricture in renal transplantation: A local center with ten years of experience

Authors

  • Akram Mahmud Department of Urology, College of Medicine, Hawler Medical University, Erbil, Iraq.

DOI:

https://doi.org/10.15218/zjms.2024.37

Keywords:

Ureter, DJ-stent, Lich-Gregoir, Hydronephrosis, Nephrostomy

Abstract

Background and objective: Renal transplantation for patients with end-stage renal disease gives better long-term survival results and a better quality of life in comparison with maintenance dialysis. However, some general and urological complications may occur following kidney transplantation. One of those complications is ureteral stricture, but the harm of renal transplant can be avoided when treated in an accurate and timely manner. This study is carried out to determine the incidence of ureteral stricture of renal transplantation, and to appropriately diagnose and treat the conditions.

Methods: A retrospective study extended from July 2011 to February 2021. In this period, 1840 renal transplant performed by our team in Rizgary teaching and Zheen international hospitals, all from living donors.

Results: Among 1840 kidney transplant surgery, 17 patients were only admitted as ureteral stricture post-transplant operation (0.92%) that diagnosed by high serum creatinine in association with hydroureteronephrosis. Hydronephrosis subsided and renal function tests nearly normalized after drainage of transplanted kidney with percutaneous nephrostomy tube. Anastomosis site stricture was observed in 16 patients (94.1%), they were treated by ureteral re-implantation. DJ-stenting and upper ureteric stricture was observed in only one patient (5.9%) that treated through pyeloplasty technique.

Conclusion: Surgical treatment is the best choice of patients with ureteral stricture, post renal transplantation. For low grade stricture, endoscopic treatment may be offered although the rate of success is not high.

Metrics

Metrics Loading ...

References

Farr M, Truby LK, Lindower J, Jorde U, Taylor S, Chen L, et al. Potential for donation after circulatory death heart transplantation in the United States: Retrospective analysis of a limited UNOS dataset. Am J Transplant 2020; 20(2):525–9. doi: 10.1111/ajt.15597

Matas AJ, Smith JM, Skeans MA, Thompson B, Gustafson SK, Stewart DE, et al. OPTN/SRTR 2013 Annual Data Report: kidney. Am J Transplant 2015; 15 Suppl 2:1–34. doi: 10.1111/ajt.13195

Hart A, Lentine KL, Smith JM, Miller JM, Skeans MA, Prentice M, et al. OPTN/SRTR 2019 Annual Data Report: Kidney. Am J Transplant. 2021; 21 Suppl 2:21–137. doi: 10.1111/ajt.16502

Solez K. History of the Banff classification of allograft pathology as it approaches its 20th year. Curr Opin Organ Transplant. 2010; 15(1):49–51. doi: 10.1097/MOT.0b013e328334fedb

Hassanein M, Augustine JJ. Chronic Kidney Transplant Rejection. StatPearls [Internet]: StatPearls Publishing; 2021.

Tawab KA, Gheith O, Al Otaibi T, Nampoory N, Mansour H, Halim MA, et al. Recurrent urinary tract infection among renal transplant recipients: risk factors and long-term outcome. Exp Clin Transplant 2017; 15(2):157–63. doi: 10.6002/ect.2016.0069

Kumar S, Ameli-Renani S, Hakim A, Jeon JH, Shrivastava S, Patel U. Ureteral obstruction following renal transplantation: causes, diagnosis and management. Br J Radiol 2014; 87(1044):20140169. doi: 10.1259/bjr.20140169

Giessing M. Transplant ureter stricture following renal transplantation: surgical options. Transpl Proc 2011; 43(1):383–6. Epub 2011/02/22. doi: 10.1016/j.transproceed.2010.12.014

Duty BD, Barry JM. Diagnosis and management of ureteral complications following renal transplantation. Asian J Urol 2015; 2(4):202–7. doi: 10.1016/j.ajur.2015.08.002

Fonio P, Appendino E, Calandri M, Faletti R, Righi D, Gandini G. Treatment of urological complications in more than 1,000 kidney transplantations: the role of interventional radiology. Radiol Med 2015; 120(2):206–12. doi: 10.1007/s11547-014-0407-y

Sabnis RB, Singh AG, Ganpule AP, Chhabra JS, Tak GR, Shah JH. The development and current status of minimally invasive surgery to manage urological complications after renal transplantation. Indian J Urol 2016; 32(3):186–91. Epub 2016/08/25. doi: 10.4103/0970-1591.185100

Kayler L, Kang D, Molmenti E, Howard R. Kidney transplant ureteroneocystostomy techniques and complications: review of the literature. Transplant Proc 2010; 42(5):1413–20. doi: 10.1016/j.transproceed.2010.04.016

Alberts VP, Idu MM, Legemate DA, Laguna Pes MP, Minnee RC. Ureterovesical anastomotic techniques for kidney transplantation: a systematic review and meta-analysis. Transpl Int 2014; 27(6):593–605. doi: 10.1111/tri.12301

Breda A OJ, Budde K, Figueiredo A, LledóGarcía E, Olsburgh J, Regele H, et al. EAU guidelines on renal transplantation. Edn. presented at the European Association of Urology Annual Congress Barcelona 2019. [Available from: https://uroweborg/guideline/renal-transplantation/ Accessed June 2022.

Suttle T, Fumo D, Baghmanli Z, Saltzman B, Ortiz J. Comparison of Urologic Complications Between Ureteroneocystostomy and Ureteroureterostomy in Renal Transplant: A Meta-Analysis. Exp Clin Transplant: Official Journal of the Middle East Society for Organ Transplantation 2016; 14(3):276–81. doi: 10.6002/ect.2015.0161

Benamran DA, Klein J, Hadaya K, Wirth GJ, Martin PY, Iselin CE. Post-kidney Transplant Robot-assisted Laparoscopic Ureteral (Donor-receiver) Anastomosis for Kidney Graft Reflux or Stricture Disease. Urol 2017; 108:96–101. Epub 2017/07/02. doi: 10.1016/j.urology.2017.05.033

Chatterjee S, Swamy PS, Hedau S, Mathur P, Bain J, Raju KP. Post-transplantation surgical complications in renal transplant recipient patients–An institution based prospective study. Indian J Transpl 2016; 10(3):65–9.

Cao C, Kim JW, Shin JH, Li M, Hong B, Kim YH, et al. Temporary Covered Metallic Ureteral Stent Placement for Ureteral Strictures following Kidney Transplantation: Experience in 8 Patients. J Vasc Interv Radiol 2020; 31(11):1795–800. doi: 10.1016/j.jvir.2020.04.004

Black AJ, Harriman D, Nguan C. Contemporary risk factors for ureteral stricture following renal transplantation. Can Urol Assoc J 2022; 16(6):E321–E7. doi: 10.5489/cuaj.7648

Minkovich M, Famure O, Li Y, Ghanekar A, Selzner M, Kim SJ, et al. Ureteral strictures post-kidney transplantation: Trends, impact on patient outcomes, and clinical management. Can Urol Assoc J 2021; 15(10):E524–E30. doi: 10.5489/cuaj.7003

Pereira H, Buchler M, Brichart N, Haillot O, d'Arcier BF, Braguet R, et al. Ureteral stenosis after renal transplantation: Risk factors and impact on survival. Prog Urol 2011; 21(6):389–96. doi: 10.1016/j.purol.2010.11.002

Eufrásio P, Parada B, Moreira P, Nunes P, Bollini S, Figueiredo A, et al., editors. Surgical complications in 2000 renal transplants. Transplant Proc 2011; 43(1):142–4. doi: 10.1016/j.transproceed.2010.12.009

Cicerello E, Merlo F, Mangano M, Cova G, Maccatrozzo L. Urolithiasis in renal transplantation: diagnosis and management. Arch Ital Urol Androl 2014; 86(4):257–60. doi: 10.4081/aiua.2014.4.257

Uflacker A, Sheeran D, Khaja M, Patrie J, Elias G, Saad W. Outcomes of percutaneous management of anastomotic ureteral strictures in renal transplantation: chronic nephroureteral stent placement with and without balloon dilatation. Cardiovasc Intervent Radiol 2015; 38(3):693–701. doi: 10.1007/s00270-014-0952-8

Pike TW, Pandanaboyana S, Hope-Johnson T, Hostert L, Ahmad N. Ureteric reconstruction for the management of transplant ureteric stricture: a decade of experience from a single centre. Transpl Int 2015; 28(5):529–34. doi: 10.1111/tri.12508

Kroczak T, Koulack J, McGregor T, editors. Management of complicated ureteric strictures after renal transplantation: case series of pyelovesicostomy with Boari flap. Transplant Proc 2015; 47(6):1850–3. doi: 10.1016/j.transproceed.2015.02.020

Gil-Sousa D, Oliveira-Reis D, Teves F, Príncipe P, Castro-Henriques A, Soares J, et al., editors. Ureteral stenosis after renal transplantation— a single-center 10-year experience. Transpl Proc 2017; 49(4):777–82. doi: 10.1016/j.transproceed.2017.01.050

Baston C, Harza M, Preda A, Gener I, Manea I, Voinea S, et al. Comparative urologic complications of ureteroneocystostomy in kidney transplantation: transvesical Leadbetter-Politano versus extravesical Lich-Gregoir technique. Transpl Proc 2014; 46(1):176–9. doi: 10.1016/j.transproceed.2013.12.003

Slagt IK, Dor FJ, Tran TC, Kimenai HJ, Weimar W, Ijzermans JN, et al. A randomized controlled trial comparing intravesical to extravesical ureteroneocystostomy in living donor kidney transplantation recipients. Kidney Int 2014; 85(2):471–7. doi: 10.1038/ki.2013.464

Downloads

Published

2024-12-19

How to Cite

Mahmud, A. (2024). Incidence and management of ureteric stricture in renal transplantation: A local center with ten years of experience . Zanco Journal of Medical Sciences (Zanco J Med Sci), 28(3), 386–392. https://doi.org/10.15218/zjms.2024.37

Issue

Section

Original Articles