The effects of adding platelet rich plasma to fat grafting to rejuvenate the face

Authors

  • Jalal H. Fattah Department of Plastic Surgery, College of Medicine, Hawler Medical University, Erbil, Iraq.

DOI:

https://doi.org/10.15218/zjms.2023.032

Keywords:

Autologous Fat grafting, PRP, Fat resorption

Abstract

Background and objective: Despite refinement in surgical techniques, fat grafting survival is unpredictable, and the resorption rate varies. The objectives of this study were to assess the effects of adding Platelet Rich Plasma (PRP) to fat grafting for facial rejuvenationin terms of longevity of the results, complications, and satisfaction rates.

Methods: The thigh or lower abdomen was chosen as a donor site for fat graft harvesting using a 10-cc syringe, then washed with saline, processed by low-speed centrifugation, and then inserted into the face with a 1 mm blunt-ended cannula at several points. on several tissue planes. A total of 369 cases treated with autologous fat graft with or without PRP for facial rejuvenation were included in this comparative study. The results were assessed clinically and followed for up to 5 years. Data analysis was done using the statistical package for social science SPSS V. 23.

Results: The commonest minor complication was fat absorption (27% in group 1 and 11.9% in group 2), no major complications were reported. Adding PRP to the fat graft decreased the need for second session fat grafting from 31.2% to 15.3%. By adding PRP to fat graft, there was a significant increase in the number of highly satisfied patients (from 63.5% to 80.1%).

Conclusion: We believe that adding PRP to autologous fat grafting has several advantages for facial rejuvenation with better long-term results, fewer complications, and better patient and surgeon satisfaction.

Metrics

Metrics Loading ...

References

Timothy M, Dino. Facial Fat Grafting: Why, Where, How, and How Much. Aesth Plast Surg 2018; 42:1278–97. DOI:10.1007/s00266-018-1179-x

Shidie C, Zhigang H, Jinghong X. Application of adipose-derived stem cells in photoaging: basic science and literature review. Stem Cell Research & Therapy 2020; 11:491. DOI:10.1186/s13287-020-01994-z

Lee P. Fat grafting for facial rejuvenation, my preferred approach. Clinics in plastic Surgery 2020; 47(1):19–29. DOI:10.1016/ j.cps.2019.08.002

Modarressi A. Platelet Rich Plasma (PRP) Improves Fat Grafting Outcomes. World J Plast Surg 2013; 2(1):6–13.

Joshua L, Oliver S, Afshin M. A systematic review of autologous platelet-rich plasma and fat graft preparation methods. Plast Reconstr Surg Glob Open 2017; 5:e1596. DOI: 10.1097/ GOX.0000000000001596

Saad I, Adham F, Iman S. Facial rejuvenation: Serial fat graft transfer. AJM 2016; 52:371–6.

Stallworth L, Wang D. Fat grafting of the midface. Facial Plast Surg 2010; 26(5):369–75. DOI: 10.1055/s-0030-1265020

Francesco S, Nicolo B, Michele G, Eugenio G, Edoardo R. Procedure, applications, and outcomes of autologous fat grafting. JAMSU 2017; 20; 49–60. DOI: 10.1016/j.amsu.2017.06.059

Marten T. Discussion of Shue et al. ‘‘Fat Injection: A Systemic Review of Injection Volumes by Facial Subunit. Aesth Plast Surg 2018; 42:1271–6. DOI:10.1007/s00266-018-1168-0

Kapil A, Manoj B, Charudatta N, Harshwardhan T, Shilpa S. Autologous Fat Transfer for Esthetic Contouring of Face in Posttraumatic Nonfunctional Maxillofacial Deformities. Craniomaxillofac Trauma Reconstruction 2016; 9(2):113–20.

Maria S, Arturo C, Ivan S, Josa E, Ignasi B, Luciano R, et al. Autologous platelet-rich plasma for treating chronic wounds. Cochrane Database Syst Rev 2016; (5)CD006899. DOI: 10.1002/14651858.CD006899.pub3

Cohn S, Lockhart E. Autologous platelet-rich plasma: evidence for clinical use. Curr Opin Hematol. 2015; 22(6):527–32. DOI: 10.1097/moh.0000000000000183

Mooren M, Merkx W, BronkM, Jansen A, Stoelinga W. The effect of platelet-rich plasma on early and late bone healing using a mixture of particulate autogenous cancellous bone and Bio-Oss: an experimental study in goats. Int J Oral Maxillofac Surg 2010; 39(4):371–8. DOI: 10.1016/j.ijom.2009.12.019

Villela L, Vera C, Santos G. Evidence on the use of platelet-rich plasma for diabetic ulcer: a systematic review. Growth Factors 2010; 28(2):111–6. DOI:10.3109/08977190903468185.

Lacci M, Dardik A. Platelet-rich plasma: support for its use in wound healing. Yale J Biol Med 2010; 83(1):1–9.

Shahin A. Platelet-rich plasma in skin rejuvenation. J Surg Dermatol 2017; 2(2):61–2. DOI:10.18282/jsd.v2.i2.150

Ahmed S, Ibrahim K, Amr N. Fat Injection for Restoration of Facial Volume and Aesthetics Versus Conventional Facelift Surgery. Egypt J Plast Reconstr Surg 2019; 43(2):325–9.

Xie Y, Zheng N, Li F. An integrated fat grafting technique for cosmetic facial contouring. J Plast Reconstr Aesthetic Surg 2010; 63(2):270–6. DOI: 10.1016/j.bjps.2008.11.016

Shinichiro N, Masayuki I, Megumi T, Kaoru M, Satoko K, Shingo N, et al. Platelet- rich plasma (PRP) promotes survival of fat-grafts in rats. Ann Plast Surg 2010; 65(1):101–6. DOI: 10.1097/SAP.0b013e3181b0273c

Martinez-Zapata MJ, Martí-Carvajal AJ, Sola I, Exposito JA, Bolibar I, Rodriguez L, et al. Autologous platelet-rich plasma for treating chronic wounds. Cochrane Database Syst Rev 2016; 2016(5):CD006899. DOI: 10.1002/14651858.CD006899.pub3.

Amable R, Carias B, Teixeira V. Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors. Stem Cell Res Ther 2013; 4(3):67.

Cohn S, Lockhart E. Autologous platelet-rich plasma: evidence for clinical use. Curr Opin Hematol 2015; 22(6):527–32. DOI: 10.1097/MOH.0000000000000183

Jordi F, Maria G, Ana V, Jose P, Jesus T. Influence of platelet-rich plasma on the histologic characteristics of the autologous fat graft to the upper lip of rabbits. Aesthetic Plast Surg 2011; 35(4):480–6. DOI: 10.1007/s00266-010-9640-5.

Kotaro Y, Sydney C. Complications of Fat Grafting How They Occur and How to Find, Avoid, and Treat Them. Clin Plastic Surg 2015; 42:383–8. DOI: 10.1016/j.cps.2015.04.002

Aleksandra S, Michał O, Ida M, Mariusz S, Małgorzata O. Jan Z.Ocular Complications Following Autologous Fat Injections into Facial Area: Case Report of a Recovery from Visual Loss After Ophthalmic Artery Occlusion and a Review of the Literature. Aesth Plast Surg 2017; 41:580–4. DOI: 10.1007/s00266-017-0805-3

Jordan G, Alex M, Nayif A, Alain A, Mirko G.A systematic review of the effectiveness and complications of fat grafting in the facial region. JPRAS Open 2019; 19:87–97. DOI: 10.1016/j.jpra.2018.12.004

Tolba M, Nasr M. Initial experience of face augmentation using fat graft-platelet rich plasma mix. Surg Sci 2015; 6:489–98. DOI: 10.4236/ss.2015.611071.

Downloads

Published

2023-12-20

How to Cite

H. Fattah, J. (2023). The effects of adding platelet rich plasma to fat grafting to rejuvenate the face . Zanco Journal of Medical Sciences (Zanco J Med Sci), 27(3), 292–300. https://doi.org/10.15218/zjms.2023.032

Issue

Section

Original Articles