Atherogenic index of plasma as a biomarker of atherogenecity in type 2 diabetes mellitus in Erbil city


  • Sardar Nouri Ahmed Department of Basic Science, College of Medicine, Hawler Medical University, Erbil, Iraq.
  • Rebwar Jalal Ali Department of Basic science, College of Medicine, Hawler Medical University, Erbil, Iraq.



Serum lipids, Atherogenesis index of plasma, Atherogenecity, T2 diabetes mellitus


Background and objective: Atherogenic index of plasma (AIP) is a mathematical method logarithmically ratio between concentrations of triglycerides to HDL-cholesterol, AIP= Log (TG/HDL), so AIP increase with increase triglycerides and reversible with HDL level. The aim of this study is to evaluation the AIP as a stronger biomarker of atherosclerosis among type 2 diabetes mellitus (DM).

Methods: This was a cross sectional-study contacted. A total of 65 patients of type 2 diabetic patient group from Laila Qasim Center for Diabetes in Erbil City collection of blood samples from 65 patients of type 2 diabetic patient group from Laila Qasim Center for Diabetes in Erbil City, compared with 50 healthy volunteers (control group). Blood samples were collected into serum separation tube (gel tube) and (K3EDTA) tube, allowed gel tube to clot at room temperature for 5 minutes then centrifuged at 4000 round per minute (rpm). The separated serum was used immediately for biochemical tests and all the laboratory investigation analysis were carried out from 2nd January to 2nd August 2021.

Results: The results of this study found that the level of serum glucose, HbA1C, albumin, CRP, and AIP in diabetics were significantly higher than healthy group, while decreasing S. HDL in diabetic patients compare with healthy individuals.

Conclusion: The study detected high level of AIP in type 2 DM patients. Accordingly, patients with type 2 DM should be followed up with regular dietary lipid intake, take lipid lowering drugs, with exercise in order to diminish AIP.


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Sultana M, Akhter Y, Parvin M, Alam M, Naznin L, Wahab M. Lipid Profile Pattern in Type 2 Diabetes Mellitus Patients. JAFMC Bangladesh. 2018; 14(2):177–9.

Florian K, Barbara K, Stefan K, Claudia L, Lyudmyla K, Christa M. Plasma Concentrations of Afamin Are Associated with the Prevalence and Development of Metabolic Syndrome. Circulation: Cardiovascular Genetics. 2014; 7(6):822–9. DOI: 10.1161/CIRCGENETICS.113.000654.

Narayan KMV. Type 2 diabetes: why we are winning the battle but losing the war? Diabetes Care. 2016; 39(5):653–63. DOI: 10.2337/dc16-0205.

Ferdinando G, Michael B. “Oxidative stress and diabetic complications,” Circulation Research. 2010;107(9):1058–70. DOI: 10.1161/CIRCRESAHA.110.223545

International diabetes foundation (IDF) Diabetes Atlas, 9th Edition. IDF. 2019. P. 13–9.

Young SG, Davies BSJ, Voss CV, Gin P, Weinstein MM, Tontonoz P, et al. GPIHBP1, an endothelial cell transporter for lipoprotein lipase. 2011; 52(11):1869–84. DOI: 10.1194/jlr.R018689

Asaad D A, Sultan A S, Hassan Z N. Atherogenic Index of Plasma among Type2 Diabetic Patients Cross-Sectional Study In Iraq. Medico Legal Update. 2020; 20(1):260–4 DOI: 10.37506/v20/i1/2020/mlu/194382

Dobiášová M, Frohlich J, Šedová M, Cheung MC, Brown BG. Cholesterol esterification and atherogenic index of plasma correlate with lipoprotein size and findings on coronary angiography. J Lipid Res. 2011; 52(3):566–71. DOI: 10.1194/jlr. P011668. PubMed: PMC3035693/

Okpa H, Enang O, Effa E. Comparative analysis of atherogenic index of plasma and is relationship with cardiovascular risk among patients with diabetes mellitus and concurrent diabetes mellitus with hypertension attending endocrinology clinic in a tertiary hospital in south Nigeria. IOSR-JDMS. 2015; 14(4):102–7. DOI: 10.9790/0853-1488102107

Tan M, Johns D, Glazer N. Pioglitazone reduces atherogenic index of plasma in patients with type 2 diabetes. Clin Chem. 2014; 50:1184-8. DOI: 10.1373/clinchem.2004.031757.

Carl A, David E. Tietz fundamentals of clinical chemistry and molecualar diagnosis.7th edition. 2015; 407–10.

Zheng Q, Kuo Z, Yueping L, Wanjun C, Zhijian W, Jianlong W, et al. The atherogenic index of plasma plays an important role in predicting the prognosis of type 2 diabetic subjects undergoing percutaneous coronary intervention: results from an observational cohort study in China. Cardiovascular Dialectology. 2020; 19(23):1–11. DOI: 10.1186/s12933-020-0989-8

Koskinas KC , Siontis GCM , Piccolo R, Franzone A , Haynes A, Rat-Wirtzler J, et al. Impact of diabetic status on outcomes after revascularization with drug-eluting stents in relation to coronary artery disease complexity: patient-level pooled analysis of 6081 patients. Circ Cardiovascular Interv. 2016; 9:e003255. DOI: 10.1161/CIRCINTERVENTIONS.115.003255.

Ting-Ting W, Ying G, Ying-Ying Z, Yi-Tong M, Xiang X. Atherogenic index of plasma (AIP): A novel predictive indicator for the coronary artery disease in postmenopausal women. Lipids in Health and Disease. 2018; 17:197.

Anping C, Guang L, Jiyan C, Xida L, Liwen L, Yingling Z. Increased serum level of Lp-PLA2 is independently associated with the severity of coronary artery diseases: a cross-sectional study of Chinese population. Cardiovascular Disorders 2015; 15:14. DOI: 10.1186/s12872-015-0001-9

Junmeng L, Ruiyue Y, Min Z, Wen M, Hongxia L, Haijian Z, et al. Fractional esterification rate of cholesterol in high-density lipoprotein associates with risk of coronary heart disease. Lipids in Health and Disease. 2017; 16:162. DOI: 10.1186/s12944-017-0545-z

Dadgarmoghaddam M, Khajedaluee M, Khaodem- Rezaiyan M, NiroumandSH,Abrishami M, Joya M, et al. Risk Factors for Non- Communicable Disease: a population based study in Mashhad (Iran). BJMMR. 2015; 7(6):503–11. DOI: 123456789/180358

Khazaal MS. Atherogenic Index of Plasma (AIP) As a Parameter in Predicting Cardiovascular Risk in Males Compared to the Conventional Dyslipidemia Indices (Cholesterol Ratios). Karbala J Med. 2013; 6(1):1506–13.

Liao J, Farmer J. Arterial stiffness as a risk factor for coronary artery disease. Curr Atheroscler Rep. 2014; 16:387. DOI: 10.1007/s11883-013-0387-8.

Kozakova M, Morizzo C, Goncalves I, Natali A, Nilsson J, Palombo C. Cardiovascular organ damage in type 2 diabetes mellitus: the role of lipids and inflammation. Cardiovasc Diabetol. 2019; 18:61. DOI: 10.1186/s12933-019-0865-6




How to Cite

Nouri Ahmed, S., & Jalal Ali, R. . (2023). Atherogenic index of plasma as a biomarker of atherogenecity in type 2 diabetes mellitus in Erbil city. Zanco Journal of Medical Sciences (Zanco J Med Sci), 27(1), 1–5.



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