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Clinical manifestation of Helicobacter pylori infection and its association with gastric adenocarcinoma in gastritis patients in Erbil, Kurdistan Region, Iraq

Tavga Hushiar Salaim
Department of Medical Microbiology , College of Health Sciences, Hawler Medical University, Erbil, Iraq.
Salah Tofik Balaky
Department of Medical Microbiology , College of Health Sciences, Hawler Medical University, Erbil, Iraq.
Rafal A. Al-Rawi
Department of Clinical Analysis , College of Pharmacy, Hawler Medical University, Erbil, Iraq.
Saman Salah eldeen Abdulla
Branch of Oral Diagnosis and Oral Medicine, College of Dentistry, Hawler Medical University, Erbil, Iraq.
Ahang Hasan Mawlood
Department of Medical Microbiology , College of Health Sciences, Hawler Medical University, Erbil, Iraq.
Abdulla Delmany
Department of Pathology, Medical College, Ninevah University, Mosul, Iraq.
Nazar M.T. Jawhar
Department of Medicine, College of Medicine, Hawler Medical University, Erbil, Iraq.
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Copyright (c) 2022 Tavga Hushiar Salaim, Salah Tofik Balaky, Rafal A. Al-Rawi, Saman Salah eldeen Abdulla, Ahang Hasan Mawlood, Abdulla Delmany, Nazar M.T. Jawhar (Author)

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Abstract

Background and objective: Helicobacter pylori can be regarded as one of the most common causes of chronic gastritis, which affects more than half of the world’s population. This study aimed to assess the presence of H. pylori in patients with gastritis and its association with gastric inflammation and adenocarcinoma.

Methods: The presence of H. pylori was detected by rapid urease test and histopathological tests using biopsy specimens. Data were analyzed using the GraphPad Software Statistical Package.

Results: The mean age of patients ± SD was 47.41 ± 18.13 years. The age range was 13 to 90 years. Results showed a significant association between the intensity of H. pylori and inflammation (P = 0.001). The more the intensity of H. pylori, the more severe the inflammation was noticed. Patients with high intensity of H. pylori had positive lymphoid aggregates. The H. pylori positive for the rapid urease test and the hematoxylin and eosin (H&E) staining test were 95.2% and 96.3%, respectively. H. pylori infection was detected in more than 85% of patients with gastric adenocarcinoma.

Conclusion: Histopathology and rapid urease tests are reliable diagnostic tools for detecting H. pylori. Results revealed a significant association of chronic active gastritis, mucosal lymphoid follicle formation, and adenocarcinoma with H. pylori infection.

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How to Cite
Salaim, T. H., Balaky, S. T., Al-Rawi, R. A., Abdulla, S. S. eldeen, Mawlood, A. H., Delmany, A., & Jawhar, N. M. (2022). Clinical manifestation of Helicobacter pylori infection and its association with gastric adenocarcinoma in gastritis patients in Erbil, Kurdistan Region, Iraq. Zanco Journal of Medical Sciences (Zanco J Med Sci), 26(2), 178–184. https://doi.org/10.15218/zjms.2022.019

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