Comparison of Acid-neutralizing capacity of antacids in Erbil City
AbstractBackground and objective: Antacids are basic substances that can neutralize hydrochloric acid and reduce gastric acidity. They are over the counter drugs used to treat dyspepsia. The most commonly used antacids are sodium bicarbonate, magnesium hydroxide, aluminum hydroxide, and calcium carbonate. This study aimed to evaluate the effectiveness of antacids that are commonly used in Erbil city by finding their acid-neutralizing capacity. Methods: The method for acid-neutralizing capacity was adapted from pharmacopeia. The samples were prepared by dissolving the antacid in an excess amount of hydrochloric acid, then neutralizing the excess acid with sodium hydroxide solution by doing back titration. The number of milliequivalents that are neutralized by the antacid is the acid-neutralizing capacity of the antacid. Results: Rennie® chewable tablet showed the highest acid-neutralizing capacity, followed by AntacidAwa and Maalux® plus. The lowest acid-neutralizing capacity was for the suspensions Gaviscon® and Enoxon®. Conclusion: Acid-neutralizing capacity is an easy and quick method to evaluate the efficacy of antacids. Different combinations of salts and concentrations can affect the acid-neutralizing capacity of the antacid. The higher the neutralizing effect of the antacid, the more effective the antacid is.
Brown M, Sharma P, Mir F, Bennett P. Gastrointestinal system. In: Bansi D, Hateley C, Louis J. Clinical Pharmacology.12th ed. London: Elsevier; 2019. P. 562–94.
Abdu K, Abbagana M, Evaluation of neutralizing capacity of different commercial brands of antacid tablets. Chem Search J 2015; 6(2):32–4.
Smith G, Arson K. Oxford text book of clinical pharmacology and drug therapy. 3rded. New York: Oxford; 2002. P. 276–7.
Sathoskar S, Bhandarkar D, Rege N. Pharmacology and pharmacotherapeutics. 21sted. Mumbai: Popular Prakashan; 2009. P. 612–6.
Tripathi D. Essentials of medical pharmacology. 6thed. New Delhi: Jeyapee; 2008. P. 627–38.
Jagadesh K, Chidananda K. Study of acid-neutralizing capacity of various antacid formulations. AJPTI 2015; 03(12):113–20.
Bhoir S, Bhagwath M. Comparison of seven oxethazine containing antacids available in Indian market. JAPI 2013; 61:400–3.
Jakaria M, Zaman R, Parvez M, Islam M, Haque A, Abu Sayeed M, et al. Comparative study among the different formulation of antacid tablets by using acid-base neutralization reaction. Global J Pharmacol 2015; 9(3):278–81.
Grinshpan D, Nevar T, Savitskaya T, Boiko A, Kapralov N, Sholomitskaya I. Comparison of acid-neutralizing properties of anti-acid preparations of various compositions. Pharm Chem J 2008; 42:400–4.
Jacob S, Shirwaikar A, Anoop S, Khaled R, Imtiaz M, Nair A. Acid neutralization capacity and cost effectiveness of antacids sold in various retail pharmacies in the United Arab Emirates. Hamdan Med J 2016; 9:137–46.
Alalor C, Avbunudiogba J, Builders F, Okpara L. Evaluation of the acid-neutralizing capacity of Some Commercially Available Brands of Antacid Tablets in Nigeria. East Afr Med J 2019; 2(1):12–6.
USP31–NF26, acid-neutralizing capacity, 301. (accessed September 5, 2019, at http://www.uspbpep.com/usp31/v31261/usp31nf26s1_c301.asp).
Al-Mudhafar M, Abdulhadi S, Talib B. Evaluation of commercial antacid tablets in Iraq. Der Pharma Chemica 2016; 8(19):283–8.
Mandel K, Daggy P, Brodie D, Jacoby H. Alginate-raft formulations in the treatment of heartburn and acid reflux. Aliment Pharmacol Ther 2000; 14:669–90.
Prajapati S, Mehta A, Modhia I, Patel C. Formulation and optimisation of raft-forming chewable tablets containing H2 antagonist. Int J Pharm Investig 2012; 2(4):176–82.
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