Evaluation of pancreatic lipase and gamma-glutamyl transferase in acute pancreatitis
Background and objective: Pancreas is a large organ behind the stomach that produces digestive enzymes and a number of hormones. Pancreatitis is a condition characterized by inflammation of the pancreas. When the digestive enzymes are activated before they are released into the small intestine, they begin attacking the pancreas, and pancreatic damage happens. This study aimed to evaluate the association between pancreatic lipase, gamma-glutamyl transferase, and acute pancreatitis in patients living in Erbil city.
Methods: The present study was carried out at the College of Medicine, Hawler Medical University from December 2017 to July 2018. A total of 35 patients with acute pancreatitis and 25 healthy controls were investigated. Examinations of serum pancreatic lipase and gamma glutamyl transferase were carried out spectrophotometrically for both groups using commercial diagnostics kits.
Results: The results showed that the mean level of serum pancreatic lipase in patients with pancreatitis was significantly higher (P <0.01)compared to normal healthy control. The mean serum gamma glutamyl transferase was higher in patients with acute pancreatitis when compared to the reference group but not statistically significant.
Conclusion: In the frame of this work, we delineate that pancreatic diseases had a significant effect on pancreatic enzymes reflected by a significant increase in serum lipase, whereas the level of gamma glutamyl transferase increased marginally.
Toh SK, Phillips S, Johnson CD. A prospective audit against national standards of the presentation and management of acute pancreatitis in the South of England. GUT 2000; 46(2):39–43.
Goldacre M J, Roberts S E. Hospital admission for acute pancreatitis in an English population, 1963–98: database study of incidence and mortality. BMJ 2004; 328:1466–9.
Roberts SE, Akbari A, Thorne K, Atkinson M, Evans PA. The incidence of acute pancreatitis: impact of social deprivation, alcohol consumption, seasonal and demographic factors. Aliment Pharmacol Ther 2013; 38:539–48.
Shen HN, Lu CL, Li CY. Epidemiology of first-attack acute pancreatitis in Taiwan from 2000 through 2009: a nationwide population-based study. Pancreas 2012; 41:696–702.
McKay CJ, Imrie CW. The continuing challenge of early mortality in acute pancreatitis. Br J Surg 2004; 91:1243.
Munoz A, Katerndahl DA. Diagnosis and management of acute pancreatitis. Am Fam Physician 2000; 62:164–74.
Matull WR, Pereira SP, O’Donohue JW. Biochemical markers of acute pancreatitis. J Clin Pathol 2006; 59:340.
Yadav D, Agarwal N, Pitchumoni C S. A critical evaluation of laboratory tests in acute pancreatitis. Am J Gastroenterol 2002;971:309–18.
Forsmark CE, Baillie J. AGA Institute technical review on acute pancreatitis. Rev Gastroenterol Mex 2007; 72:257–85.
Swaroop V S, Chari S T, Clain J E. Acute severe pancreatitis. JAMA 2004; 291(23):2865– 8.
Tenner S, Baillie J, DeWitt J, Vege SS, American College of Gastroenterology American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol 2013; 108:1400–15.
Batra H, Kumar A, Saha T, Misra P, Ambade V. Comparative study of serum amylase and lipase in acute pancreatitis patients. Indian Journal of Clinical Biochemistry 2015; 30(2):230–3.
Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, et al. Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis--2012 revision of the Atlanta classification and definitions by international consensus. Gut 2013; 62:102–11.
Lippi G, Valentino M, Cervellin G. Laboratory diagnosis of acute pancreatitis: in search of the Holy Grail. Crit Rev Clin Lab Sci 2012;49:18–31.
Frossard JL, Steer ML, Pastor CM. Acute pancreatitis. Lancet 2008; 371:143–52.
Werner J, Feuerbach S, Uhl W. Management of acute pancreatitis: from surgery to interventional intensive care. Gut 2005; 54(3):426–36.
UK working party on acute pancreatitis. UK guidelines for the management of acute pancreatitis. Gut 2005; 54(Suppl 3):iii1–9.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The copyright on any article published in Zanco J Med Sci is retained by the author(s) in agreement with the Creative Commons Attribution Non-Commercial ShareAlike License (CC BY-NC-SA 4.0).