Association of thrombocytopenia with preeclampsia in a sample of women during labor
Background and objective: Thrombocytopenia (platelet count < 150 × 109/L) is considered the second leading responsible factor in blood disorders in pregnancy after anemia. Substantial thrombocytopenia has been shown to associate with medical conditions. The present study aimed to compare the levels of platelets during labor between the patients diagnosed with preeclampsia and their age-matched healthy subjects.
Methods: In this case-control study, the thrombocytopenia was compared between 55 patients diagnosed with preeclampsia and 59 age-matched healthy controls. In this study, the thrombocytopenia was categorized as follows; normal (150-400 × 109/L), mild (100-149 × 109/L), moderate (50-99 × 109/L), and severe (<50 ×109/L).
Results: The study showed that the cases and controls were comparable in general information. The number of platelets was significantly lower in patients with preeclampsia (73.58 ± 26.05) compared to the controls (262.05 ± 81.01; and the P <0.0001). The serum bilirubin (P <0.0001) and the serum creatinine (P = 0.002) were substantially lower in the cases compared to the controls in contrast with urine protein (P <0.0001). The patients with preeclampsia were more likely to undergo an emergency cesarean section (65.5% vs. 11.9%), to have antepartum hemorrhage complications (67.3% vs. 18.6%), to get any kind of hypertensive disorders in pregnancy, and to admit the newborns to neonatal intensive care unit (60.0% vs. 35.6%).
Conclusion: The present study showed that the preeclamptic patients had lower platelet count compared to non-pre-eclamptic. In addition, they were more likely to have more obstetrical complications.
Say L, Chou D, Gemmill A, Tunçalp Ö, Moller A-B, Daniels J, et al. Global causes of maternal death: a WHO systematic analysis. The Lancet Global Health 2014; 2(6):e323–33.
English FA, Kenny LC, McCarthy FP. Risk factors and effective management of preeclampsia. Integr Blood Press Control 2015; 8:7.
McCrae KR. Thrombocytopenia in pregnancy. ASH Annual Meeting 2010; 2010(1):397–402.
Heilmann L, Rath W, Pollow K. Hemostatic abnormalities in patients with severe preeclampsia. CATH 2007; 13(3):285–91.
Stavrou E, McCrae KR. Immune thrombocytopenia in pregnancy. Hematology/Oncology Clinics 2009; 23(6):1299–316.
Asrie F, Enawgaw B, Getaneh Z. Prevalence of thrombocytopenia among pregnant women attending antenatal care service at Gondar University Teaching Hospital in 2014, northwest Ethiopia. J Blood Med 2017; 8:61.
Donimath KV, Sambrani AM, Rathod PM. A study on association of thrombocytopenia with pregnancy induced hypertension. IJRCOG 2017; 5(3):808–12.
Wang X, Xu Y, Luo W, Feng H, Luo Y, Wang Y, et al. Thrombocytopenia in pregnancy with different diagnoses: Differential clinical features, treatments, and outcomes. Medicine 2017; 96(29):e7561.
Myers B. Thrombocytopenia in pregnancy. TOG 2009; 11(3):177–83.
Sibai BM, Committee P, Medicine SfM-F. Evaluation and management of severe preeclampsia before 34 weeks' gestation. AJOG 2011; 205(3):191–8.
Boehlen F, Hohlfeld P, Extermann P, Perneger TV, De Moerloose P. Platelet count at term pregnancy: A reappraisal of the threshold. Obstet Gynecol 2000; 95(1):29–33.
Jalal SD, Thanoon AM. Thrombocytopenia in Iraqi pregnant women. J Fac Med 2011; 53(2):171–4.
Perepu U, Rosenstein L. Maternal thrombocytopenia in pregnancy. POG 2013; 3(1):1–15.
Shamoon RP, Muhammed NS, Jaff MS. Prevalence and etiological classification of thrombocytopenia among a group of pregnant women in Erbil City, Iraq. Turk J Hematol 2009; 26(23):123–8.
Levy JA, Murphy LD. Thrombocytopenia in pregnancy. JABFM 2002; 15(4):290–7.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The copyright on any article published in Zanco J Med Sci is retained by the author(s) in agreement with the Creative Commons Attribution Non-Commercial ShareAlike License (CC BY-NC-SA 4.0).