Nandrolone effects on men’s semen parameters in Erbil city
Keywords:Nandrolone, Men, Semen parameters, Abnormal shape, Infertility
Background and objective: Anabolic androgenic steroids are synthetic compounds based on the structure of testosterone, and are used to treat various conditions such as reproductive system dysfunction. High doses of anabolic androgenic steroids and exercise influence the hypothalamic pituitary gonadal axis, which can, in turn, affect testicular apoptosis. This study aimed to investigate the influence of anabolic androgenic steroids on semen parameters in bodybuilders (heavy exercise) in Erbil city.
Methods: Semen specimens and serum were collected from 150 which divided into three groups; each consists of 50 men. The control group (A) didn't practice exercise so didn't receive nandrolone. The exercise group (B) who practice daily without taking nandrolone. The exercise and treated group (C) who practice exercise and had been using nandrolone (200 mg- wk-1, intramuscularly) for at least three months. Smear prepared by methyline blue stain and assessment of semen volume, sperm morphology, sperm concentration ,motility were carried out .Serum levels of follicle-stimulating hormone, luteinizing hormone, and testosterone were also carried out.
Results: There was no difference in the semen volume within three groups. Sperm concentration and the percentage of sperm motility in the group C was significantly lower (P <0.001) than that in the other groups. A significantly increased percentage of sperm with the tapered head was found in the group C. Our results also demonstrated a significant decrease in testosterone and follicle-stimulating hormone in the group C compared to group A and B.
Conclusion: Users of anabolic-androgenic steroids have sperm with abnormal shape, especially tapered head, and low concentration of sperm with sluggish motility attributing to infertility.
Kopera H. The history of anabolic steroids and a review of clinical experience with anabolic steroids. Acta Endocrinologica 1985;271:11–8.
Sheffield-Moore M, Urban RJ. An overview of the endocrinology of skeletal muscle. Trends Endocrinol Metabol TEM 2004; 15: 110–5.
Deyssig R, Weissel M. Ingestion of androgenicanabolic steroids induces mild thyroidal impairment in male body builders. J Clin Endocrinol Metab 1993;76:1069-107.
Sravonee P, Rita M. Effect of Nandrolone Decanoate on Serum FSH, LH and Testosterone Concentration in Male Albino Mice. World Journal Life Science and Medical Research 2012; 2(3) : 123.
Torres-Calleja J, González-Unzaga M, DeCelis-Carrillo R, Calzada-Sánchez L, Pedrón N. Effect of androgenic anabolic steroids on sperm quality and serum hormone levels in adult male bodybuilders. Life Sciences 2001;68:1769–74.
Dohle GR , Smith M ,Weber RF. Androgen and male fertility.World J Urol 2003; 21:341 – 5.
Mesbah SF , Shokri S, Doust SK. Effects of nandrolone decanoate on ultrastructure of testis in male adult rats . Iran J Med Sci 2008 ; 33 (2): 94 – 100 .
Johnson LG , Fisher G , Silvester LJ , Hofhein CC. Anabolic steroid :Effects on strength, body Weight, oxygen uptake and spermatogenesis upon mature males . Med Sci Sports 1972; 4: 43– 5.
Eliakim A, Nemet D . Exercise and the male reproductive system. Harefuah 2006;145(9): 677-81.
De Souza MJ, Arce JC, Pescatello LS, Scherzer HS, Luciano AA. Gonadal hormones and semen quality in male runners. A volume threshold effect of endurance training. Int J Sports Med 1994; 15(7):383-91.
Kujala UM, Alen M, Huhtaniemi IT. Gonadotrophin-releasing hormone and human chorionic gonadotrophin tests reveal that both hypothalamic and testicular endocrine functions are suppressed during acute prolonged physical exercise. Clinical Endocrinology 1990; 33: 219–25.
Safarinejad MR, Azma K, Kolahi AA. The effects of intensive, long-term treadmill running on reproductive hormones, hypothalamus–pituitary–testis axis, and semen quality: a randomized controlled study. Journal of Endocrinology 2009; 200: 259-71.
Feinberg MJ, Lumia AR, McGinnis MY. The effect of anabolicandrogenic steroids on sexual behavior and reproductive tissues in male rats. Physiol Behav 1997;62:23–30.
Shokri S, Aitken RJ, Abdolvahhabi M, Abolhasani F, Ghasemi FM, Kashani I, et al. Exercise and Supraphysiological Dose of Nandrolone Deconoate Increase Apoptosis in Spermatogenic cells. Basic & Clinical Pharmacology & Toxicology 2010; 106: 324–30.
Tahtamouni LH, Mustafa NH, Hassan IM, Ahmad IM, Yasin SR, Abdalla MY. Nandrolone Decanoate Administration to Male Rats Induces Oxidative Stress, Seminiferous Tubules Abnormalities, and Sperm DNA Fragmentation. Jordan Journal of Biological Sciences 2010; 3:165–74.
McLachlan RI, Wreford NG, O’Donnell L De, Kretser DM , Robertson DM. The endocrine regulation of spermatogenesis independent roles for testosterone and FSH. J Endocrinol 1996;148: 1-9.
Watanabe N. Decreased number of sperms and Sertoli cells in mature rats exposed to diesel exhaust as fetuses. Toxicology Letters 2005;155: 51-8.
WHO laboratory manual for the examination and processing of human semen - 5th ed. Geneva: Switzerland World Health Organization; 2010.
Seed J, Chapin RE, Clegg ED, Dostal LA, Foote RH, Hurtt ME, et al. Methods for assessing sperm motility, morphology, and counts in the rat, rabbit, and dog: a consensus report. ILSI Risk Science Institute Expert Working Group on Sperm Evaluation. Reprod Toxicol 1996; 10: 237-44.
Ahmed F. AlDomairy MD. Histological and Ultrastructural Study of the Effect of Nandrolone on the Testis of Adult Male Albino Rat. J Am Sci 2013;9(5):104.
Ferrari F, de Paiva Foletto M, de Moraes SM, Peres SB, Segatelli TM, da Costa CE..Testis morphophysiology of rats treated with nandrolone decanoate and submitted to physical training. Acta Scientiarum Health Sciences 2013; 35: 164-66.
Lombardo F, Sgro P, Salacone P, Gilio B, Gandini L, Dondero F, et al . Androgens and fertility. Journal of Endocrinological Investigation 2004 ;28:51-5.
Takahashi M, Tatsugi Y, Kohno T. Endocrinological and pathological effects of anabolic-androgenic steroid in male rats. Endocrine Journal 2004; 51(4):425-34.
Pope Jr HG, Brown KJ. Treatment of anabolic androgenic steroid-related disorder. USA: American Psychiatric publishing Inc ;2008.
Farrell SF, Mc Ginnis MY. Long –term effect of pubertal anabolic androgenic steroid exposure on reproductive and aggressive behaviours in male rats. Horm Behav 2004;46:193-203. [PubMed].
Karbalay-Doust S, Noorafshan A, Ardekani FM, Mirkhani H . The reversibility of sperm quality after discontinuing nandrolone decanoate in adult male rats. Asian J Androl 2007; 9(2):235-9.
Soares JM, Duarte JA . Effects of training and an anabolic steroid on murine red skeletal muscle, a stereological analysis. Acta Anat1991; 142(2):183-7
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