Human papillomavirus and herpes simplex virus infections in patients with mucocutaneous lesions can be linked to host TBX-21 gene polymorphism
DOI:
https://doi.org/10.15218/zjms.2021.033Keywords:
HPV genotypes, HSV-2 infection, Genital lesion, T-bet polymorphismAbstract
Background and objective: Human papillomavirus (HPV) and herpes simplex-2 (HSV-2) are the common cause of genital lesions in women. The variation in host genetic makeup can determine the consequence of a viral infection in that host. T-bet gene polymorphism has been associated with the incidence of several types of infections. This study investigates the impact of T-bet polymorphism on the incidence of HPV and HSV in genital lesions.
Methods: 215 women, including 71 HPV infected, 72 HSV-2 infected, and 72 controls were enrolled. Viral genotyping was done on genital swab samples using Realtime PCR. In all participants, the extracted DNA from blood was tested for T-bet gene variation at Ch17.rs17244587 G>A site using ARMS-PCR. ELISA was done to participants sera to detect HSV-1 IgM.
Results: Genotyping of HPV infection revealed that (73.0%) were at low risk. Most individuals (72.5%) were homozygous GG, while (20.9%) were heterozygous AG and (6.5%) were homozygous AA, of which 92.8% were HSV-2 infected patients. None of 18 (8.4%) HSV-1-IgM positive women were homozygous AA.
Conclusion: T-bet gene allele A appears to be linked with more incidence of HSV-2 in genital lesions, but such influence was not observed for HPV genotypes and HSV-1.
Metrics
References
Torcia MG. Interplay among vaginal microbiome, immune response and sexually transmitted viral infections. Int J Mol Sci. 2019; 20(2):266. https://doi.org/10.3390/ijms20020266.
Bahena-Román M, Sánchez-Alemán MA, Contreras-Ochoa CO, Lagunas-Martínez A, Olamendi-Portugal M, López-Estrada G, et al. Prevalence of active infection by herpes simplex virus type 2 in patients with high-risk human papillomavirus infection: A cross-sectional study. J Med Virol. 2020; 92(8):1246–52. https://doi.org/10.1002/jmv.25668.
Graham SV. The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review. Clin Sci. 2017; 131(17):2201–21. https://doi.org/110.1042/CS20160786.
Norenhag J, Du J, Olovsson M, Verstraelen H, Engstrand L, Brusselaers N. The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta-analysis. BJOG An Int J Obstet Gynaecol. 2020; 127(2):171–80. https://doi.org/10.1111/1471-0528.15854.
Chan CK, Aimagambetova G, Ukybassova T, Kongrtay K, Azizan A. Human papillomavirus infection and cervical cancer: Epidemiology, screening, and vaccination - Review of current perspectives. J Oncol. 2019; 2019:3257939. https://doi.org/10.1155/2019/3257939.
Lin C, Franceschi S, Clifford GM. Human papillomavirus types from infection to cancer in the anus, according to sex and HIV status: a systematic review and meta-analysis. Lancet Infect Dis. 2018; 18(2):198–206. https://doi.org/10.1016/S1473-3099(17)30653-9.
Koelle DM, Norberg P, Fitzgibbon MP, Russell RM, Grninger AL, Huang ML, et al. Worldwide circulation of HSV-2 × HSV-1 recombinant strains. Sci Rep. 2017; 7(February): 1–12. https://doi.org/10.1038/srep44084.
Kim HC, Lee HK. Vaccines against genital herpes: Where are we? Vaccines. 2020; 8(3): 1–13. https://doi.org/10.3390/vaccines8030420.
Simonetta F, Pradier A, Roosnek E. T-bet and eomesodermin in NK cell development, maturation, and function. Front Immunol. 2016; 7:241. https://doi.org/10.3389/fimmu.2016.00241.
Patel R, Kennedy OJ, Clarke E, Cowan FM, Kinghorn GR, Munday PE, et al. European guidelines for the management of genital herpes. Int J STD AIDS. 2017; 28(14):1366–79. https://doi.org/10.1177/0956462417727194.
Huang Y, Dai H, Ke R. Principles of Effective and Robust Innate Immune Response to Viral Infections: A Multiplex Network Analysis. Front Immunol. 2019; 10(July):1736. https://doi.org/10.3389/fimmu.2019.01736.
Kenney AD, Dowdle JA, Bozzacco L, McMichael TM, St. Gelais C, Panfil AR, et al. HHS Public Access. 2018: 51:241–63. https://doi.org/10.1146/annurev-genet-120116–023425.
McLaughlin RN, Malik HS. Genetic conflicts: The usual suspects and beyond. J Exp Biol. 2017; 220(1):6–17. https://doi.org/10.1242/jeb.148148.
Casaca VI, Illi S, Suttner K, Schlpeich I, Ballenberger N, Klucker E, et al. TBX21 and HLX1 polymorphisms influence cytokine secretion at birth. PLoS One. 2012; 7(1):1–8. https://doi.org/10.1371/journal.pone.0031069.
Zhu DY, Deng XZ, Zhu YM, Li GT, Zhang GQ, Wang LJ, et al. Association of IL-28B, TBX21 gene polymorphisms and predictors of virological response for chronic hepatitis C. Arch Virol. 2018; 163(5):1253–62. https://doi.org/10.1007/s00705-018-3750-9.
Sivori S, Pende D, Quatrini L, Pietra G, Chiesa MD, Vacca P, et al. NK cells and ILCs in tumor immunotherapy. Mol Aspects Med. 2020; 80:100870. https://doi.org/10.1016/j.mam.2020.100870.
Ge M, Zheng Y, Li X, Shi J, Ge J. The polymorphisms of T cell–specific TBX21 and STAT4 genes may contribute to the susceptibility of Chinese individuals to aplastic anemia. Hum Immunol. 2012; 73(1):118–21. https://doi.org/10.1016/j.humimm.2011.11.007.
White AA, Stevenson DD. Aspirin-exacerbated respiratory disease. N Engl J Med. 2018; 379(11):1060–70. https://doi.org/10.1056/NEJMra1712125.
Sun W, Wu HY, Chen S. Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding. World J Gastroenterol. 2017; 23(48):8500–11. https://doi.org/10.3748/wjg.v23.i48.8500.
Lazarevic V, Glimcher LH. T-bet in disease. Nat Immunol. 2011; 12(7):597–606. https://doi.org/10.1038/ni.2059.
Sánchez D, Lefebvre C, García LF, Barrera LF. Variants in the IFNγ transcription factor genes TBET, STAT1, STAT4, and HLX and the risk of pulmonary tuberculosis in a Colombian population: a case-control study. Biomedica. 2013; 33(2):259–67.
Mansournia MA, Jewell NP, Greenland S. Case–control matching: effects, misconceptions, and recommendations. Eur J Epidemiol. 2018; 33(1):5–14. https://doi.org/10.1007/s10654-017-0325-0.
Mahmoodi P, Fani M, Rezayi M, et al. Early detection of cervical cancer based on high-risk HPV DNA-based genosensors: A systematic review. Bio Factors. 2019; 45(2):101–17. https://doi.org/10.1002/biof.1465.
Xavier-Carvalho C, Cardoso CC, de Souza Kehdy F, Pacheco AG, Moraes MO. Host genetics and dengue fever. Infect Genet Evol. 2017; 56:99–110. https://doi.org/10.1016/j.meegid.2017.11.009
Chapman SJ, Hill AVS. Human genetic susceptibility to infectious disease. Nat Rev Genet. 2012; 13(3):175–88. https://doi.org/10.1038/nrg3114.
Zhang Y, Zhang Y, Gu W, He L, Sun B. Th1/Th2 cell’s function in immune system. In: T helper cell differentiation and their function. Springer 2014; 45–65. https://doi.org/10.1007/978-94-017-9487-9_3.
Svensson A, Tunbäck P, Nordström I, Padyukov L, Eriksson K. Polymorphisms in Toll-like receptor 3 confer natural resistance to human herpes simplex virus type 2 infection. J Gen Virol. 2012; 93(8):1717–24. https://doi.org/10.1099/vir.0.042572-0.
Viera MH, Amini S, Huo R, Konda S, Block S, Berman B. Herpes simplex virus and human papillomavirus genital infections: new and investigational therapeutic options. Int J Dermatol. 2010; 49(7):733–49. https://doi.org/10.1111/j.1365-4632.2009.04375.x.
Dursun P, Ayhan A, Mutlu L, et al. HPV Types in Turkey: Multicenter hospital based evaluation of 6388 patients in Turkish gynecologic oncology group centers. Turkish J Pathol. 2013; 29(3): 210–6. https://doi.org/10.5146/tjpath.2013.01188.
Akcali S, Goker A, Ecemis T, Kandiloglu AR, Sanlidag T. Human papilloma virus frequency and genotype distribution in a Turkish population. Asian Pacific J Cancer Prev. 2013; 14(1):503–6. https://doi.org/10.7314/apjcp.2013.14.1.503.
Cossu G, Previtali SC, Napolitano S, Cicalese MP, Tedesco FS, Nicastro F, et al. Intra‐arterial transplantation of HLA‐matched donor mesoangioblasts in Duchenne muscular dystrophy. EMBO Mol Med. 2015; 7(12):1513–28. https://doi.org/10.15252/emmm.201505636.
Rubicz R, Leach CT, Kraig E, Dhurndhar N, Duggirala R, Blangero J, et al. Genetic factors influence serological measures of common infections. Hum Hered. 2011; 72(2):133–41. https://doi.org/10.1159/000331220.
Bakkeheim E, Mowinckel P, Carlsen KH, Håland G, Carlsen KCL. Paracetamol in early infancy: the risk of childhood allergy and asthma. Acta Paediatr. 2011; 100(1):90–6. https://doi.org/10.1111/j.1651-2227.2010.01942.x.
Rodriguez-Flores JL, Fakhro K, Agosto-Perez F, Ramstetter MD, Arbiza L, Vinncent TL, et al. Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations. Genome Res. 2016; 26(2):151–62. https://doi.org/10.1101/gr.191478.115.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The copyright on any article published in Zanco J Med Sci is retained by the author(s) in agreement with the Creative Commons Attribution Non-Commercial ShareAlike License (CC BY-NC-SA 4.0).