A Relationship between blood group and gastric carcinoma in Erbil city: A case-control study

Abdullah Saeed Ibrahim

doi:10.15218/zjms.2021.029

Authors

Abdullah Saeed Ibrahim Department of Medicine, college of Medicine, Hawler Medical university, Erbil, Iraq.

DOI:

https://doi.org/10.15218/zjms.2021.029

Keywords:

Gastric carcinoma, ABO blood group, Erbil

Abstract

Background and objective: Gastric carcinoma can be caused by the interaction between environmental factors and genetic variations. The relationship between ABO blood groups and carcinogenesis or progression of human tumors has been reported by many investigations. This study aimed to understand the correlation between ABO blood groups and the risk of developing gastric carcinoma.

Methods: This case-control study included the ABO blood group and rhesus system of 92 patients diagnosed with gastric carcinoma at Erbil city from 2017 to 2019. Informed consent was obtained from all patients. As a control, the blood group from 260 healthy blood donors was collected from Erbil blood bank.

Results: Of 92 patients, 58.7% were males, and 41.3% were females. The mean age was 62 (28 - 97) years. Regarding the type of gastric carcinoma, 58.7% were intestinal, and 41.3% were diffuse type. Blood group and rhesus system of patients and control were compared. Blood group O was 47.8% in cases versus 40.8% in control and 42.6% in all participants, followed by blood group A (31.5% of gastric carcinoma patients and 26.5% of control with a total of 27.8% of all participants). Regarding the Rhesus system, 92.4% of cases were Rh⁺, and 7.6% were Rh^- compared with 92.9% Rh⁺and 7.1% Rh^- in control. None of them was statistically significant.

Conclusion: There was no statistically significant association between blood groups and gastric carcinoma, although blood group O was more common, followed by A.

Metrics

Metrics Loading ...

References

Siegel R, Naishadham D, Jemal A. Cancer statistics. CA Cancer J Clin. 2013; 63(1):11–30. https://doi.org/10.3322/caac.21166.

Nakao M, Matsuo K, Ito H, Shitara K, Hosono S, Watanabe M, et al. ABO genotype and the risk of gastric cancer, atrophic gastritis, and Helicobacter pylori infection. Cancer Epidemiol Biomarkers Prev. 2011; 20(8):1665–72. https://doi.org/10.1158/1055-9965.EPI-11-0213.

Wang Z, Liu L, Ji J, Zhang J, Yan M, Zhang J, et al. ABO blood group system and gastric cancer: a case-control study and meta-analysis. Int J Mol Sci. 2012; 13(10):13308–21. https://doi.org/10.3390/ijms131013308.

Liumbruno GM, Franchini M. Beyond immunohaematology: The role of the ABO blood group in human diseases. Blood Transfus. 2013; 11(4):491–9. https://doi.org/10.2450/2013.0152-13.

Edgren G, Hjalgrim H, Rostgaard K, Norda R, Wikman A, Melbye M, et al. Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. Am J Epidemiol. 2010; 172(11): 1280–5. https://doi.org/10.1093/aje/kwq299.

Heike I, Grabscha B, Patrick T. Gastric Cancer Pathology and Underlying Molecular Mechanisms. Dig Surg. 2013; 30:150–8. https://doi.org/10.1159/000350876.

Rawla P, Barsouk A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Prz Gastroenterol. 2019; 14(1):26–38. https://doi.org/10.5114/pg.2018.80001.

Zhang BL, He N, Huang YB, Song FJ, Chen KX. ABO blood groups and risk of cancer: a systematic review and meta-analysis. Asian Pac J Cancer Prev. 2014; 15(11):4643–50. https://doi.org/10.7314/apjcp.2014.15.11.4643.

Ali Z, Bhaskar SB. Basic statistical tools in research and data analysis. Indian J Anaesth. 2016; 60(9):662–9. https://doi.org/10.4103/0019-5049.190623.

Karimi P, Islami F, Anandasabapathy S, Freedman ND, Kamangar F. Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomarkers Prev. 2014; 23(5):700–13. https://doi.org/10.1158/1055-9965.EPI-13-1057.

Chakrani Z, Robinson K, Taye B. Association between ABO blood groups and Helicobacter pylori infection: A Meta-Analysis. Sci Rep. 2018; 8:17604. https://doi.org/10.1038/s41598-018-36006-x.

Jaff MS. Relation between ABO blood groups and Helicobacter pylori infection in symptomatic patients. Clin Exp Gastroenterol. 2011; 4:221–6. https://doi.org/10.2147/CEG.S23019.

Lahmidani N, El Yousf M, Aqodad N, Benajah D, El Abkari M, Ibrahimi A, et al. Update on gastric cancer epidemiology and risk factors. Journal of Cancer Therapy. 2018; 9(3):242–54. https://doi.org/10.4236/jct.2018.93021.

Cotoi BV, Georgescu I. An epidemiological assessment of gastric cancer. CHSJ. 2010; 36(2): 74–7. https://doi.org/10.12865/CHSJ.36.02.05.