Evaluation of serum gamma glutamyl transferase activity among type-2 diabetic patients in Erbil
Methods: A cross-sectional study was carried out from January to June 2016 in collaboration between the Clinical Biochemistry Department at the College of Medicine, Hawler Medical University and the Chemistry Department at the Faculty of Science and Health of Koya University. The study included 50 type 2 diabetic patients (group 1), and 50 healthy individuals (group 2).
Results: The mean value of serum gamma glutamyl transferase activity was significantly higher in type 2 diabetic patients (group 1) than that of healthy individuals (group 2) (P <0.001). The mean value of serum gamma glutamyl transferase activity in men diabetic patients was non significantly lower than women diabetic patients. The mean value of serum gamma glutamyl transferase activity in diabetic patients whose age was ≥50 years was non significantly higher than diabetic patients whose age was <50 years.
Conclusion: Based on the findings of the present study, it can be concluded that high serum gamma glutamyl transferase activity is an independent factor and has considerable potential in diagnosing and monitoring for type 2 diabetic patients.
Zimmet P, Williams J, Courten M. Diagnosis and classification of diabetes mellitus in: John A., Wass and Stephen M. Shalet (eds). Oxford textbook of endocrinology and diabetes. New York: Heln Liepman; 2002. P. 1635.
Kaku K. Pathophysiology of type 2-diabetes mellitus and its treatment policy. JMAJ 2010; 53(1):41–6.
Dufour D, Lott J, Nolte F, Gretch D, Koff R, Seef L. Diagnosis and monitoring of hepatic injury performance characteristics of laboratory tests. Clin Chem 2000; 46(12):2027–49.
Whitfield JB. Gamma glutamyl transferase. Crit Rev Clin Lab Sci 2001; 38:263–355.
Emdin M, Pompella A, Paolicchi A. Gamma glutamyl transferase, atherosclerosis, and cardiovascular disease: triggering oxidative stress within the people. Circulation 2005; 112:2078–80.
Sharma R, Sharma S, Kaushik G. Gamma glutamyl transferase- a novel marker of endothelial dysfunction? JIACM 2010; 11(1):26–30.
Hanley AJ, Williams K, Festa A, Wagenknecht LE, Dagosteno RB, Kempf J, et al. Elevations in markers of liver injury and risk of type-2 diabetes; the insulin resistance atherosclerosis study. Diabetes 2004; 53(10):2623–32.
Nakanishi N, Nishana K, Li W, Sato M, Suzuki K, Tatara K. Serum gamma glutamyl transferase and development of impaired fasting glucose of type-2 diabetes in middle-aged Japanese men. J Intern Med 2033; 254(3):287–95.
Wannamethee SG, Lennon L, Shaper AG, Whincup PH. Hepatic enzymes, the metabolic syndrome, and the risk of type-2 diabetes in older men. Diabetes Care 2005; 28(12):2913–8.
Lee DH, Jacohs DR, Gross M. Gamma glutamyl transferase is a predictor of incident diabetes and hypertension: the CARDIA study. Clin Chem 2003; 49(8):1358–66.
Talabani NS. Serum gamma-glutamyltransferase activity: Inhibitory study in patient of hepatitis. IOSR-JAC 2013; 4(1):44–7.
Daniel WW, Chad L. Cross. Biostatistics: A foundation for analysis in the health science. 10th ed. USA: John Wiley and Sons; 2013.
Baros AM, Wright TM, Latham PK, Miller PM, Anton RF. Alcohol consumption, %CDT, GGT and blood pressure change during alcohol treatment. 2008. Alcohol and Alcoholism 2007; 43(2):192–7.
Ukayama H. General Laboratory Manual. Department of Pathology, Hackensack University Medical Centre; 2010. P. 117.
Hsueh WA, Quinones MJ. Role of endothelial dysfunction in insulin resistance. Am J Cardiol 2003; 92(4A):10J–7.
Manjunatha Goud BK, Nayal B, Sarsina DO, Sathisha TG, Shivashanker S, Devaki, RN. Relation of calculated HbA1c with fasting plasma glucose and duration of diabetes. Int J Appl Biol Pharm Technol 2011; 2(2):58–61.
American diabetes association, American diabetes association's new clinical practice recommendations promote HbA1C as diagnostic test for diabetes, standards of medical care in diabetes. Diabetes Care 2010; 33:S11–69.
Duk-Hee Lee, Gross MD, Steefers MW, Jacobs DR. Is serum gamma-glutamyl transferase a biomarker of xenobiotics, which are conjugated by glutathione? Arterioscler Thromb Vasc Biol 2008; 28:e26–8.
Ruttmann E, Brant LJ, Concin H, Diem G, Rapp K. The Vorarlberg health monitoring and promotion program study group. Gamma glutamyltransferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163944 Austrian adults. Circulation 2005; 112(14):2130–7.
Nakanishi N, Suzuki, Tatara K. Serum gamma glutamyltransferase and risk of metabolic syndrome and type 2 diabetes in middle-aged Japanese men. Diabetes Care 2004; 27:1427–32.
Gholamreza Y, Mostafa S, Mahboobeh Y, Hamid N. Role of gamma-glutamyl transferase in diagnosis of impaired glucose tolerance and metabolic syndrome: A prospective cohort research from the Kerman Coronary Artery Disease Risk Study (KERCADRS). Diabetes & Metabolic Syndrome: Clin Res Rev 2012; 6:190–4.
Andre P, Balkau B, Born C, Charles MA, Eschwege ED. E.S.I.R. study group. Three-year increase of gamma-glutamyl transferase level and dependent of type 2 diabetes in middle-aged men and women: the D.E.S.I.R. cohort. Diabetologia 2006; 49:2599–603.
Lippi G, Targher G, Montagnana M, Salvango GL, Guidi GC. Relatioship between γ- glutamyl transferase, lipids and lipoprotein (a) in the general population. Clin Chem Acta 2007; 384:163–6.
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