Comparative study between cryotherapy and salicylic acid in the treatment of plantar warts in Erbil - Iraq
Keywords:Cryotherapy, Salicylic acid, Plantar wart, Erbil
Background and objective: Plantar warts are hard, grainy growths that usually appear on the heels or balls of feet. Plantar warts are caused by the human papillomavirus, usually self-limiting, but treatment is generally recommended to lessen symptoms, decrease duration, and reduce transmission. The study aimed to evaluate the clinical effectiveness of topical 40% salicylic acid in comparison to cryotherapy in the treatment of plantar wart.
Methods: This study was conducted from March 2015 to January 2016 on 70 patients with plantar wart who attended the consultation clinic of dermatology department in Rizgary teaching hospital. Patients were randomly allocated to two groups: cryotherapy treatment with liquid nitrogen every two or three weeks and self-application of salicylic acid daily.
Results: Sixty patients aged 12 to 60 years were included in the analysis at 13 weeks. Cure rates were 66.7% in the cryotherapy group and 80% in the salicylic acid group. A significant association was found between the duration of wart before treatment and cure rates (P <0.001).
Conclusion: No difference in effectiveness between cryotherapy and topical salicylic acid 40% in the treatment of plantar warts was found.
James WD, Berger TC, Elestone DM. Viral diseases. In: Andrews Disease of the Skin: Clinical Dermatology. 10th ed. Philadelphia: WB Saunders Company; 2006.
Sterling JC. Viral infections. In: Burns T, Breathnach S, Cox N, Griffiths C, eds. Rook’s Text Book of Dermatology. 7th ed. Italy: Blackwell Scientific Publication; 2004.
Elliot J A, Douglas R L. Warts. In: Wolff K, Goldsmith L A, Katz S, Gilchrest B A, Paller A S, Leffel J, Fitzpatrick TB (eds). Fitzpatrick’s Dermatology in General Medicine. 7th ed. NewYork: Mac Graw- Hill; 2008.
Kirnbauer R, Lenz P. Human. Papilloma viruses. In: Bolognia JL, Jorizzo JL, Schaffer JV. Editors. Dermatology. 3rd ed. United States: Elsevier Saunders; 2012.
Sladden MJ, Johnston GA. Common skin infections in children. Clinical review. BMJ 2004; 329: (7457):95-9.
Habif TP. Wart. Herpes simplex and other viral infections. In: Clinical dermatology. 4th ed. Philadelphia: Mosby; 2004.
Grimes PE. Salicylic acid. In: Tosti A, Grimes PE, De Padova MP, editors. Color Atlas of Chemical Peels. 2nd ed. New York: Springer; 2012. P. 49-57.
Sterling JC, Handfield-Jones S, Hudson PM. Guidelines for the management of cutaneous warts. Br J Dermatol 2001; 144:4-11.
Bertram G K, Susan B M, Anthony J T. Basics and clinical pharmacology. 12th ed. McGraw-Hill; 2012.
Mittal A, Mehta S. Human papilloma virus and hepatitis A, B and C infections. In: Singal A, Grover C. editors. Comprehensive approach to infections in dermatology. London: Jaypee Brothers Medical Pub; 2016. P. 240-59.
Stulberg DL, Hutchinson AG. Molluscum contagiosum and warts. Am Fam Physician 2003; 67:1233-40.
Stulberg DL, Hutchinson AG. Physicians need more evidence on treatments of warts: in reply. Am Fam Physician 2003; 68:1714-6.
Zimmerman E, Crawford P. Cutaneous surgery. Am Fam Physician 2012; 86:1118-24.
Bruggink SC, Gussekloo J, Zaaijer K, Assendelft WJJ, Berger MY, Koes BW, et al. Cryotherapy with liquid nitrogen versus topical salicylic acid application for cutaneous warts in primary care: randomized controlled trial. CMAJ 2010:182 (15):1624-30.
Steele K, Irwin W. Liquid nitrogen and salicylic/lactic acid paint in the treatment of cutaneous warts in general practice. Br J Gen Pract 1988; 38(311):256-8.
Micali G, Dall’Oglio F, Nasca MR. Topical treatments for cutaneous warts: an update. Expert
Rev Dermatol 2013; 8(1):15-7.
Cockayne S, Hewitt C, Hicks K, Jayakody S, Kang, Ombs AR, et al. Cryotherapy versus salicylic acid for the treatment of planter wart. BMJ 2011; 342:3271.
Gibbs S, Harvey I, Sterling J, Stark R. Local treatments for cutaneous warts: systematic Review. BMJ 2002; 325(7362):461.
Kaçar N, Taşlı L, Korkmaz S, Ergin Ş, Erdoğan BŞ. Cantharidin–podophylotoxin– salicylic acid versus cryotherapy in the treatment of plantar warts: a randomized prospective study. J Eur Acad Dermatol Venereol 2012; 26(7):889-93.
Kwok CS, Gibbs S, Bennett C, Holland R, Abbott R. Topical treatments for cutaneous warts. Cochrane Database Syst Rev [abstract]; 2012:9.
Larsen PQ, Laurberg G. Cryotherapy of viral warts. J Dermatolog Treat 1996; 7(1):29-31.
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