Iron Body Status, Ceruloplasmin Levels and Oxidative Stress in Pre- and Postmenopausal Women at Baghdad City
Keywords:
Iron, ferritin, Transferrin receptor, MalondialdehydeAbstract
Background and Objectives: Estimation of different iron body status markers, ceruloplasmin and oxidative stress in pre- and postmenopausal women at Baghdad city.
Methods: This study was performed at the Chemistry and Biochemistry Department, College of medicine, Al-Nahrain University, Baghdad, Iraq from January 2009 to October 2009. The study consisted of 42 healthy women categorized into two groups premenopausal women (n= 22) aged 29.71±8.92 years and postmenopausal women (n=20) aged 53.33±4.61 years. Iron, total iron binding capacity (TIBC) were measured colorimetrically, ferritin levels were measured by enzyme linked immunosorbent assay (ELISA), ceruloplasmin level was estimated by radial immunodiffusion technique whereas malondialdehyde was quantified colorimetrically
Results: Non-significant increase (P>0.05) in iron, ferritin levels, transferrin saturation percents in sera of postmenopausal women and non- significant increase (P>0.05) in total iron binding capacity (TIBC), transferrin, iron stores in sera of premenopausal women. Malondialdehyde increased non- significantly (P=0.44) in premenopausal women whereas ceruloplasmin increased significantly (P=0.000) in postmenopausal women group. On the other hand ferritin was correlated positively and significantly with body mass index (BMI) (r= 0.696; P < 0.05) and with ceruloplasmin levels (r=0.725; P<0.05) in pre- and postmenopausal women.
Conclusions: Hormonal changes which usually associated with menopause may be the cause of increased oxidative stress and consequent rise in ceruloplasmin levels as an antioxidant response
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