Immunohistochemical Expression of Carbohydrate Antigen CA19-9 in Colorectal Tumors
Keywords:
Colon adenocarcinoma, CA19-9Abstract
Background and Objectives: Carbohydrate antigen 19-9 (CA19-9) is one of the most representative tumor markers in colorectal carcinomas. Colorectal cancer is one of the leading causes of cancer-related mortality in the world. The objective of this study is to investigate the expression of CA 19-9 in colon tumors and its correlation with pathological prognostic factors (age, gender, tumor site and histological grade).
Methods: A total of 47 colonic tissues were selected from Razgary teaching hospital from the period January, 2007 to January, 2009 consisting of 20 colonic adenocarcinoma, five tubular adenoma,12 retention polyp, four ulcerative colitis and six normal colonic mucosa.
Results: CA19-9 expression found in 18 out of 20 colonic adenocarcinoma, 2 out of 5 tubular adenoma and one out six normal colonic tissues
Conclusions: It was concluded that high expression of CA19-9 is seen more frequently in colonic adenocarcinoma with higher grade tumor in comparison with benign tumor and normal tissue. There was also high CA19-9 expression in old age patient (>50 years) and in male gender.
Key words: Colon adenocarcinoma, CA19-9.
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References
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