Randomized, Prospective Comparison of Post-Operative Pain In Low - Versus High -Pressure Pneumoperitoneum in Laparoscopic Cholecystectomy
DOI:
https://doi.org/10.15218/zjms.2010.020Keywords:
Laparoscopic cholecystectomy, pneumoperitoneum, postoperative painAbstract
Background and objective: CO2 insuflation constitutes the commonest means of creat-ing the pneumoperitoneum (PP), but it is attributed to many post-laparoscopic cholecyste-comy adverse effects including pain triggering. The aim of this trial was to evaluate the effi-cacy of low-pressure CO2 PP during laparoscopic cholecystectomy (LC) in reducing the incidence of postoperative pain.
Methods: A double-blind, randomized, clinical trial was conducted on 100 patients with symptomatic gall stones. Patients were randomized preoperatively into group A (n=50) who underwent LC with 8 mmHg CO2 PP throughout the procedure and those in group B (n=50) had LC with 12 mmHg CO2 PP. Abdominal and shoulder-tip pain were assessed with verbal rating scale (VRS) scoring at 4, 8, 12 and 24 hours postoperatively.
Results: The low-pressure PP did not increase the duration of surgery. There were neither significant peri-operative complications nor conversion to open procedure in either group. A statistical comparison of mean cumulative VRS scores for abdominal and shoulder-tip pain in both groups shows statistical significance at 4, 8, 12 and 24 hours after operation.
Conclusion: A CO2 PP at 8 mmHg reduces both the frequency and intensity of abdomi-nal and shoulder-tip pain following LC without increasing the rate of intra-operative compli-cations.
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References
Deirdre M, Sallyann C, Jackie R, et al. Intraperito-neal Pethidine versus Intramuscular Pethidine for the Relief of Pain after Laparoscopic Cholecystec-tomy: World J. Surg 2002; 26, 1432� 36.
Pourseidi B, Khorram-Manesh A. Effect of inter-costals neural blockade with Marcaine (bupivacaine) on postoperative pain after laparo-scopic cholecystectomy, Surg Endosc 2007;21: 1557�59.
Ure B.M, Troid F, Spangenberger W. et al. Pain after laparoscopic cholecystectomy Intensity and localization of pain and analysis of predictors in preoperative symptoms and intraoperative events. Surg Endosc 1994; 8:90-96.
Jakimowicz J, Stultiens G, Smulders F. Laparo-scopic insuflation of the abdomen reduces portal venous flow. Surg Endosc 1998; 12: 129�32.
Koc M, Ertan T, Tez M, et al. Randomized, pro-spective comparison of postoperative pain in low Vs high pressure pneumoperitoneum. ANZ J. Surg 2005 75: 693-6.
Davides D, Birbas K, Vezakis A, et alx. Routine low-pressure pneumoperitoneum during laparo-scopic cholecystectomy. Surg Endosc 1999;13: 887�9.
Bisgaard T, Kehlet H, and Rosenberg J. Pain and Convalescence after Laparoscopic Cholecystec-tomy. Eur J Surg 2001; 167: 84�96.
Sarli L, Costi G, Sansebeastiano G. et al. Pro-spective randomized trial of low-pressure pneu-moperitoneum for reduction of shoulder-tip pain following laparoscopy. Br J Surg 2000; 87, 1161- 5.
Neudecker J, Sauerland S, Neugebauer E, et al. The European Association for Endoscopic Sur-gery clinical practice guideline on the pneumop-eritoneum for laparoscopic surgery. Surg Endosc 2001; 16: 1121� 43.
Pappas-Gogos G, Konstandinos E. Tsimogiannis � et al. Preincisional and intraperitoneal ropiva-caine plus normal saline infusion for postoperative pain relief after laparoscopic cholecystectomy: a randomized double-blind controlled trial Surg En-dosc 2008; 22:2036� 45.
Bonnie PG, Marie JL, Meng KO, et al. Celecoxib premedication in post-operative analgesia for laparoscopic cholecystectomy. Acute pain 2004;6, 23-28.
Koivusalo A.-M., Pere P,Valjus M, Scheinin T. Laparoscopic cholecystectomy with carbon diox-ide pneumoperitoneum is safe even for high-risk patients Surg Endosc 2007;19: 1988-91.
Larsen J, Ejstrud P, Svendsen F, et al .Systemic response in patients undergoing laparoscopic cholecystectomy using gasless or carbon dioxide pneumoperitoneum: A randomized study. J Gas-trointestinal Surg 2004; 6: 584- 6.
Uzunkoy A, Ozgonul A, Ceylan E, and Gencer M. The effects of isothermic and hypothermic car-bon dioxidepneumoperitoneum on respiratory function test results J Hepatobiliary Pancreat Surg 2006; 13:567�70.
Bashirov E, Cetiner S, Emre M, et al. A random-ized controlled study evaluating the effects of the temperature of insufflated CO2 on core body tem-perature and blood gases (an experimental study) Surg Endosc 2007; 21: 1820�5.
Alijani A, Hanna B, and Cuschieri A. Abdominal Wall Lift Versus Positive-Pressure Capnoperito-neum for Laparoscopic Cholecystectomy Ran-domized Controlled Trial Annals of Surgery 2004; 239:234-7.
Davides D, Birbas K, Vezakis A, et al. Routine low-pressure pneumoperitoneum during laparo-scopic cholecystectomy. Surg Endosc 1999;13: 887�9.
Rosch R, Junge K, Binneb�sel M. Gas-related impact of pneumoperitoneum on systemic wound healing.Langenbecks Arch Surg 2008 393:75�80.
Karagulle E, Turk E, Dogan R, Ekici Z, Dogan R, and Moray G. The effects of different abdominal pressures on pulmonary function test results in lapaorsocopic cholecystectomy. Sur laprosc En-dosc Percutn Tech 2008;18(4):229-33.
Wallace DH, Serpell MG, Baxter JN, et al. Ran-domized trial of different insufflation pressure for laparoscopic cholecystectomy. Br J Surg 1997 84: 455 �8.
Schaube H, ebhardt J.H, Loose D. Pathophysi-ologische aspekte des CO2 pneumoperitoneums-die beeinflussung der herz-kreislaufparameter im zeitichen verlauf. Acta. Chir. Au 1995;6: 532- 4.
Zuckerman R, Gold M, Jenkins P, et al. The ef-fects of pneumoperitoneum and patient position on hemodynamics during laparoscopic cholecys-tectomy Surg Endosc 2001;15: 561� 5.
Tsereteli Z, Terry ML, et al. Prospective random-ized clinical trial compairing nitrous oxide and
carbon dioxide pneumoperitoneum for laparoscopic surgery. J Am Coll Surg 2002; 195:173.
Gupta A. Local anesthesia for pain relief after laparoscopic cholecystectomy a systematic re-view. Best practice & research clinical Anaesthe-siology2005;19:275�92.
Bisgaard T, Klarskov B, Kristiansen VB, et al. Multi-regional local anesthetic infiltration during laparoscopic cholecystectomy in patients receiv-ing prophylactic multi-modal analgesia: a random-ized, double-blinded, placebo-controlled study. Anesth Analg 1999; 89: 1017� 24.
Joris J, Thiry E, Paris P, et al. Pain after laparo-scopic cholecystectomy: characteristics and effect of intraperitoneal bupivacaine. Anesth Analg 1995;81: 379�84.
Lepner U, Goroshina J & Samarutel J. Postop-erative pain relief after laparoscopic cholecystec-tomy: a randomised prospective double-blind clinical trial. Scand J Surg 2003; 92: 121�4.
Barczyn�ski M, Herman R. M. Low pressure pneumoperitoneum combined with intraperitoneal saline washout for reduction of pain after laparo-scopic cholecystectomy: Surg. Endosc 2004; 18: 1368- 73.
Louizos A. A, Hadzilia S. J., Leandros E, et al . Postoperative pain relief after laparoscopic cholecystectomy. A placebo-controlled double-blind randomized trial of preincisional infiltration and intraperitoneal instillation of levobupivacaine 0.25%, Surg Endosc 2005;19: 1503�6.
Nursal T, Yildirim S, Tarim A, et al. Effect of drainage on postoperative nausea, vomiting, and pain after laparoscopic cholecystectomy. Langen-becks Arch Surg 2003;388:95�100.
Vezakis A, Davides D, Gibson JS, et al. Ran-domized comparison between low pressure laparoscopic cholecystectomy and gasless laparoscopic cholecystectomy. Surg Endosc 1999;13: 890�3.
Gupta A, Thorn SE, Axelsson K, et al. Postop-erative pain relief using intermittent injections of 0.5% ropivacaine through a catheter after laparo-scopic cholecystectomy. Anesth Analg 2002;95: 450�6.
Esmat M, Magdy M.A. Magid M.A, et al. Com-bined low pressure pneumoperitoneum and in-traperitoneal infusion of normal saline for reducing shoulder tip pain following laparoscopic cholecys-tectomy. World J Surg 2006;30: 1969�73.
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