Comparison of Benzyl Benzoate Lotion Versus Permethrin Solution in Addition to Crotamiton Cream as Adjuvant Therapy In the Treatment of Scabies Infestation
Keywords:Comparison, Benzyl Benzoate, Versus Permethrin, Crotamiton Cream
Background and Objectives: To compare the efficacy of topical benzyl benzoate lotion with permethrin solution in addition to adjuvant crotamiton cream with the aim of determining better and improved treatment option for scabies.
Subject and Methods: The trial included 150 patients aged 6–65 years with scabies who attended the Al-qudis health center for family medicine in Mosul city. Inclusion criteria: those experiencing itching and presence of burrows or secondary lesions that were characteristic of scabies on at least three sites of predilection for scabies. Exclusion criteria: serious illness, pregnant or lactating women, treatment of scabies within the preceding 1 month and suspicious cases. Eligible subjects were divided to 2 groups both of them received topical treatment consisted of a thorough bath using sulfur soap followed by application of benzyl benzoate lotion 25% for adult and 12.5%for children to all parts of the body, repeated daily for 3 consecutive days and after 1 week, the. While the other group applied permethrine 5% solution as the same manner of benzyl benzoate lotion, washed after 12 hours and repeated after 1 week. In addition, topical treatment involved application of crotamiton cream (40g) mixed with betamethasone G cream (15g) as adjuvant antiscabietic therapy and antipruritic for both groups, in addition to symptomatic treatment of itching. Where possible, close contacts of subjects with scabies were examined and those clinically confirmed to have scabies were invited to enroll in the study. All subjects and close contacts were treated simultaneously. Subjects were followed up at 2 weeks to assess compliance and examine the patients those with new or persistent lesions and pruritus were treated but excluded .Criteria for cure were absence of pruritus and of new lesions.
Results: At 2-weeks post-treatment, the treatment was effective in 70(87.5%) patients in the permethrin group and 45(64%) patients in the benzyl benzoate group, the difference between them was significant (p< 0.0001).The 35 patients who had not improved were excluded
Conclusion: The diagnosis of scabies requires a willing physician and a cooperative patient with increased awareness to achieve good control and successfully treatment of this health problem. Moreover, improved personal hygiene may prevent or control the spread of scabies.
Chasidic M. Scabies.NEGM 2006; 354: 1718 -1727.
William D, Timothy G, Dirk M. Parasitic infestations, stings and bites. Andrews` Diseases of The skin,Clinical Dermatology, 4th ed. Oxford, UK: Blackwell Publishing; 2008. p. 452-453.
Mimouni D, Gdalevich M, Mimouni F, Haviv J. The epidemiologic trends of scabies among Israeli soldiers: a 28-year follow-up .International Journal of Dermatology1998; 378: 586-7.
Mimouni D, Ankol O, Davidovitch N. Seasonality trends of scabies in a young adult population: a 20-year follow-up. British Journal of Dermatology 2003; 149: 157–9.
Scheinfeld N. Controlling scabies in institutional settings: a review of medications, treatment models and implementation. American Journal of Clinical Dermatology2004; 5: 31–7.
Downs A, Harvey I, Kennedy C .The epidemiology of head lice and scabies in the UK. Epidemiology and Infection 1999; 122: 471–7.
Evdokia D, Steve G, Jeanette L. The Management of Scabies infection in the Community 2007; www.hpa.org.uk .
Graham J , Sladden . Scabies: diagnosis and treatment; BMJ 2005; 331: 619–622
Hay. Scabies Journal of the European Academy of Dermatology and Venereology 2004; 18:129–30.
Karthikeyan K .Treatment of scabies:newer perspectives. Postgrad Med J 2005;81: 7–11.
Arlian L .Biology, host relations, and epidemiology of Sarcoptes scabiei. Annual Review of Entomology 1989; 34:139–61.
Green M .Epidemiology of scabies. Epidemiologic Reviews 1989; 11:126–50.
Geneva .The current evidence for the burden of group A streptococcal diseases. World Health Organization 2005; Available from: http://www.who.int/child_adolescent_health/documents/fch_cah_05_07/en/
Taplin D, Meinking T, Porcelain S, Castilero P, Chen J. Permethrin 5% dermal cream: a new treatment for scabies. J Am Acad Dermatol 1986; 15: 995–1001.
Walker G,Johnston P .A systemic Review of the treatment of scabies. Arch Dermatol 2000;136.
Narendra P, Bachewar, Vijay R, Thawani .Comparison of safety,efficacy and cost effectiveness of benzyl benzoate, pemethrin and ivermectin in patients of scabies2009;[http://www.ijp online.com].
Glaziou P,Cartel J, Alzieu P.Comparison of ivermectin and benzyl benzoate for treatment of scabies. Tropical Medicine and Parasitolog 1993 ; 44: 331–2.
Halima M, Sule, Tom D. Comparison of ivermectin and benzyl benzoate lotion for scabies in Nigerian patients; Am .J .Trop .Med. Hyg. 2007;76(2):392–395
Cubela V .Clinical experience with crotamiton cream and lotion in the treatment of infants with scabies.Br J Clin Prct 1978; 32: 229–31
Konstantinov D, Stanoava I, Yawalker S. Crotamiton cream and lotion in the treatment of infants with scabies; J Int Med Res1979; 7: 443.
Strong M , Johnstone P .Interventions for treating scabies. In: The Cochrane Library 2007; 3.
NHS Centre for reviews and dissemination. Effectiveness matters treating head lice and scabies 1999;4:1.
Chosidow O .Scabies and pediculosis. Lancet 2000; 355: 819–21.
Alexander J .Arthropods and skin .Springer-Verlag 1984; 50–5.
Walker G, Johnstone P. Interventions for treating scabies. The Cochrane Library1999;Issue 2. Oxford: Update Software
Speare R .Advice on scabies diagnose and management. Fact sheet 2008.
NZDS. Scabies. New Zealand Dermatological Society Incorporate. Derm Net NZ 2008. [http://www.dermnetnz.org/arthropods/scabies.html]
Fatimata L, Eric C, Cheick A .Comparison of human scabies treatments in Senegal Ivermectin versus benzyl benzoate applied once or twice to treat human scabies in Dakar, Senegal; Bulletin of the WHO Article 2009; 354:1718-1727.
Sladden M, Johnston G .Common skin infections in children. BMJ 2004; 329: 95-9.
Ihsan, Semsettin, Omer. (2006). Prevalence of pediculosis and scabies in preschool nursery children of Afyon, Turkey; Korean of Parasitology 44: 95-98.
Afzalur R, Zannatun N .Predisposing Factors of Scabies Among the Patients Attending Skin and Venereal Disease Outdoor of Dhaka Medical College Hospital;J Medicine 2008; 9: 82-86.
Kentucky .Scabies. Kentucky Epidemiologic notes and reports 2002;37: 9.[www.cdc.gov].
How to Cite
The copyright on any article published in Zanco J Med Sci is retained by the author(s) in agreement with the Creative Commons Attribution Non-Commercial ShareAlike License (CC BY-NC-SA 4.0).