Lipid Peroxidation and Antioxidant Status in Post-Operative Patients with Cancer Treated with Chemotherapy
Keywords:lipid peroxidation, total antioxidants status, chemotherapy, cancer
Background and Objectives: The aim of this study was to assess the effect of surgical interference and chemotherapy on lipid peroxidation and antioxidant status in patients with cancer disease.
Methods: Twenty one male patients with gastric, colonic, and prostate cancer; and 26 apparently healthy male subjects as a control group, were included in this study. Blood samples (5 ml) were taken from patients and controls and analysed for serum malondialdehyde (MDA) and total antioxidant status (TAS). Blood samples were taken from patients one week before and after the surgery and other blood samples were taken two weeks after the first dose of chemotherapy.
Results: In the cancer patients, serum MDA was significantly higher (P<0.001), while serum TAS was significantly lower (P<0.001) compared with the controls. After surgical removal of cancer, serum MDA was decreased significantly (P<0.001), but serum TAS was increased significantly (P<0.001) compared with the patients before surgery. Chemotherapy treatment further increased serum MDA significantly (P<0.001), with a significant (P<0.001) decrease in serum TAS compared with the measurements after operation.
Conclusions: Surgical removal of cancer decreased lipid peroxidation, and increased antioxidant status. Chemotherapy of cancer increased lipid peroxidation and depressed antioxidant defense system. Oxidative stress might be a consequence and not a cause of cancer.
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