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Physical and chemical compatibility of intravenous metronidazole infusion with physiological solutions: UV-Visible Spectroscopy study

Ali I. Al-Gareeb
Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Iraq
Hayder M. Al-Kuraishy
Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Iraq
Marwan S.M. Al-Nimer
Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Iraq
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  • Submited: October 30, 2018
  • Published: October 30, 2018

Abstract

Background and Objectives: The instructions of the manufacturer showed that metronidazole infusion solution (5mg/mL) is incompatible with few drugs. This study aimed to determine the physical and chemical compatibilities of metronidazole infusion with commonly used intravenously administered physiological solutions.

Methods: Metronidazole injection in a commercially available concentration of 5mg/mL was mixed with 0.9% sodium chloride, 5% glucose saline or Ringer's solution in the infused bottle or during simulated Y-site injection. metronidazole was examined physically by visual inspection and chemically by ultraviolet-visible spectrophotometer analysis. Adsorption of metronidazole to intravenous administration sets without inline filters was also studied. Furthermore, the compatibility of metronidazole with some drugs related to beta-lactams was studied. Physical incompatibility was determined by visual inspection against a blackand- white background, and chemical incompatibility was measured by a stability-indicating UV-visible spectrophotometer assay for metronidazole.

Results: The absorbance magnitude (O.D.) recorded by UV-visible spectrophotometer showed differences in respect to the infused solutions as well as to the admixed physiological solutions. Moreover, metronidazole is incompatible with Co-amoxicillin and clavulanic acid, and cefepime. .

Conclusions: It is concluded that metronidazole infusion should be separately infused, not admixed with physiological solutions and avoided its combination with beta lactams.

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How to Cite
Al-Gareeb, A. I., Al-Kuraishy, H. M., & Al-Nimer, M. S. (2018). Physical and chemical compatibility of intravenous metronidazole infusion with physiological solutions: UV-Visible Spectroscopy study. Zanco Journal of Medical Sciences (Zanco J Med Sci), 14(1 Special), 67–71. Retrieved from https://zjms.hmu.edu.krd/index.php/zjms/article/view/504

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