Retrospective Comparison of Weight Gain between Olanzapine- and Risperidone-Treated Patients
Background and Objectives: Weight gain as a side effect of the second generation antipsychotics have been increasingly noted during therapy; however no studies addressed such a valid clinical concern in Iraq till now. The objective of this study was to determine the weight changes among patients treated with either Olanzap-ine or Risperidone.
Methods: A retrospective study was performed by reviewing the charts of 80 patients who have been treated with Olanzapine monotherapy (60 patients) or Risperidone monotherapy (20 patients) through the period of April 2008 to April 2009, compar-ing the baseline weight in kilograms with after one month of therapy weight.
Results: Among the 60 patients treated with Olanzapine, 42 (70%) gained weight, 70.37% of males and 69.69% of females treated with Olanzapine gained weight. Among the 20 patients treated with Risperidone, 12 (60%) gained weight, 50% of males and 75% of females treated with Risperidone gained weight. Those treated with Olanzapine, gained 3.96 kg after 30 days of treatment, while the amount of gain was 2.25 kg among those treated with Risperidone after the same period. Olanzapine-treated group gained about 6.21% of their baseline weight which was significantly higher than that of Risperidone-treated group who gained about 2.89% of their baseline weight (P value of 0.03). Females gained more amount of weight than males in both group.
Conclusions: Both second generation antipsychotics, Olanzapine and Risperidone, are associated with weight gain. However, Olanzapine appears to have a greater potential in inducing weight gain. Both genders affected nearly equally, though females were victims of more amount of weight gain.
Davis JM, Chen N, Glick ID. A meta-analysis of the efficacy of second-generation antipsychotics. Arch Gen Psychiatry. 2003; 60(6): 553-64.
Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, et al. Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators. Effectiveness of antipsy-chotic drugs in patients with chronic schizophre-nia. N Engl J Med. 2005; 353(12): 1209-23.
Allison DB, Mentore JL, Heo M, Chandler LP, Cappelleri JC, Infante MC, Weiden PJ. Antipsy-chotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry. 1999; 156(11): 1686-96.
Vanina Y, Podolskaya A, Sedky K, Shahab H, Siddiqui A, Munshi F, and Lippmann S. Body weight changes associated with psychopharma-cology. Psychiatric Services. 2002; 53: 842-7.
Asher-Svanum H, Stensland M, Zhao Z, Kinon BJ. Acute weight gain, gender, and therapeutic re-sponse to antipsychotics in the treatment of pa-tients with schizophrenia. BMC Psychiatry. 2005; 5: 3.
Haddad P. Weight changes with atypical antipsy-chotics in the treatment of schizophrenia. J Psy-chopharmacol. 2005; 19 (Suppl 6): 16-27.
Newcomer JW. Second generation (atypical) an-tipsychotics and metabolic effects: a comprehen-sive literature review. CNC Drugs. 2005; 19(Suppl I): 1-93.
Henderson DC. Schizophrenia and comorbid metabolic disorders. J Clin Psychiatry. 2005; 66(Suppl 6): 11-20.
Gentile S. Long-term treatment with atypical antip-sychotics and the risk of weight gain. A literature analysis. Drug Safety. 2006; 29(4): 303-19.
Goff DC, Cather C, Evins AE, Henderson DC, Freudenreich O, Copeland PM, Beirer M, Duckworth K, Sacks FM. Medical morbidity and mortality in schizophrenia: guidelines for psychia-trists. J Clin Psychiatry. 2005; 66(2): 183-94.
Curkendall SM, Mo J, Glasser DB, Rose Stang M, Jones JK. Cardiovascular disease in patients with schizophrenia in Saskatchewan, Canada. J Clin Psychiatry. 2004; 65(5): 715-20.
Megna JL, Raj Kunwar A, Wade MJ. A retro-spective study of weight changes and the contrib-uting factors in short term adult psychiatric inpa-tients. Ann Clin Psychiatry. 2006; 18(3): 163-7.
Daumit GL, Goldberg RW, Anthony C, Dickerson F, Brown CH, Kreyenbuhl J, et al. Physical activity patterns in adults with severe mental illness. J Nerv Ment Dis. 2005; 193(10): 641-6.
Sokal J, Messias E, Dickerson FB, Kreyenbuhl J, Brown CH, Goldberg RW, Dixon LB . Comorbidity of medical illnesses among adults with serious mental illness who are receiving community psy-chiatric services. J Nerv Ment Dis. 2004; 192(6): 421-7.
Thakore JH. Metabolic disturbance in first-episode schizophrenia. Br J Psychiatry. Suppl 2004; 47: S76-S79.
Meltzer HY, Perry E, Jayathilake K. Clozapine-induced weight gain predicts improvement in psy-chopathology. Schizophr Res. 2003; 59(1): 19-27.
Gasquet I, Haro JM, Novick D, Edgell ET, Ken-nedy L, Lepine JP, SOHO Study Group. Pharma-cological treatment and other predictors of treat-ment outcomes in previously untreated patients with schizophrenia: results from the European Schizophrenia Outpatient Health Outcomes (SOHO) study. Int Clin Psychopharmacol. 2005; 20(4): 199-205.
Eder U, Mangweth B, Ebenbichler C, Weiss E, Hofer A, Hummer M, et al. Association of Olan-zapine-Induced Weight Gain with an Increase in body fat: Brief Report. Am J Psychiatry. 2001; 158: 1719-22.
Baptista T. Body weight gain induced by antipsy-chotic drugs: mechanisms and management. Acta Psychiatr Scand. 1999; 100:3-16.
Wirshing DA, Wirshing WC, Kysar L, Barisford MA, Goldstein D, Pashdag J, et al. Novel antipsy-chotics: comparison of weight gain liabilities. J Clin Psychiatry. 1999; 60: 358-63.
Hummer M, Kemmler G, Kurz M, Kurtzthaler I, Oberbauer H, Fleischhacker WW. Weight gain induced by clozapine. Eur Neuropsycopharmacol. 1995; 5: 437-40.
Basson BR, Kinon BJ, Taylor CC, Szymanski KA, Gilmore JA, and Tollefson GD. Factors influencing acute weight change in patients with schizophre-nia treated with olanzapine, haloperidol, or risperi-done. J Clin Psychiatry. 2001; 62:231-8.
Kraus T, Haack M, Schuld A, Hinze-Selch D, Kuhn M, Uhr M, Pollmacher T. Body weight and leptin plasma levels during treatment with antipsy-chotic drugs. Am J Psychiatry. 1999; 156:312-4.
Wirshing DA, Spellberg BJ, Erhart SM, Marder SR, Wirshing WC. Novel antipsychotics and new onset diabetes. Biological Psychiatry. 1998; 44(8): 778-83.
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