Certain virulence characteristics of common bacteria involved in urinary tract infection in Erbil setting
Keywords:
Antibiotic, biofilm, hemolysis, UTIAbstract
Background and objectives: Urinary tract infections carry a high risk of recurrence and antibiotic resistance due to biofilm formation. This study aims to identify the common bacterial pathogen responsible for UTI in Erbil setting and identify their pathogenic characteristics and sensitivity to commonly used antibiotics, using the minimal inhibitory concentration (MIC) method.
Methods: 96-flat wells microtiter plate was used for detection of the degree of biofilm formation of E. coli strains isolated from patients with urinary tract infection. Standard breakpoint MIC have been compared with MIC results of antibiotics
Results: Only 5.6% of total samples showed UTI, the most common bacterial isolate was E. coli (43.2%). Around 26% of pyuric cases appeared to be of sterile type. The biofilm formation involved 9.4% strong adhesion. Around 50% of isolates showed beta hemolysis. The most sensitive antibiotics include nitrofurantine (81.3%), gatifluxacin (40.6%) and Ciprofloxacine (37.5%).
Conclusion: Most common pathogens in UTI are E.coli. There was no correlation between biofilm formation and the presence of any of the other virulence factor such as antibiotic resistants and hemolysis. The more effective antibiotics against E.coli in this setting are gatifluxacine, Ciprofloxacin and nitrfuratoin having most MIC fall close to their standard breakpoints.
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