Serum sialic acid and its lipid and protein bounds as possible biomarkers of acute myocardial infarction in Erbil city
DOI:
https://doi.org/10.15218/zjms.2011.0010Keywords:
AMI, TSA, LBSA, PBSAAbstract
Backgrounds and objectives: Myocardial infarction (MI) usually occurs when coronary blood flow decreases abruptly after a thrombotic occlusion of a coronary artery previously affected by atherosclerosis. Sialic acid (SA) is attached to non reducing residues of the carbohydrate chains of glycoproteins and glycolipids. An elevation in seru TSA, LBSA and PBSA concentrations has been observed in a number of pathological conditions .The aim of the study was to determine the serum TSA and its LBSA and PBSA in patients with acute myocardial infarction (AMI).
Methods: Serum TSA, LBSA and PBSA concentrations were evaluated by UV/VIS spectrophotometry in (100) apparently healthy individuals and (100) newly diagnosed AMI patients.
Results: The mean levels of serum TSA, LBSA and PBSA in AMI patients were significantly higher (P< 0.5) than those of apparently healthy individuals.
Conclusion: The results indicate that the serum values of TSA, LBSA and PBSA appeared to be of a value in diagnosis of AMI.
Metrics
References
- Kasap S ,Gonenc A , Sener D.E. et al.Serum cardiac markers in patients with AMI :Oxidative stress , C-reactive protein and N-terminal probrain natriuretic peptide .J.Clin.Bioch.Nutr. 2007 ;41 (1) : 50-7
- Pasupathi P.Y., Yagneswara R , Jawahar F et al.Oxidative stress and cardiac biomarkers in patients with AMI Eur.J.Sci.Res. 2009 ; 27 : 275-85
- Nina L., Helena G. and Tatu AM.Sialic acid content of LDL-C and its relation to lipid concentrations and metabolism of LDL-C and cholesterol. J.Lipid Res. 2000 ; 41: 1842-49
- MAHMOUD TJ , BABAN AA and AHMED SA.Clinical usefulness of alteration in serum total sialic acid and its ratio to total protein in breast masses in Hawler city . ZJMS ,2009 ; 12(2) :18-23
- Pönniö M ,Alho H ,Nikkari ST, et al Serum sialic acid in random sample of the general population .Clin.Chem. 1999b ; 45 : 1842-49
- Hangloo VK , Kaul I ,and Zargar HU.Serum sialic acid levels in healthy individuals.J.Postgrad.Med. 1990 ; 36 :140-42
- Nigam PK ,Narain VS , and Ajay K.Sialic acid in cardiovascular diseases. Ind.J.Clin.Bioch. 2006 ;21(1) :54-61
- Zafar T and Iqbal Z.Estimation of sialic acid in cardiac patients . Professional Med. J. 2008 ;15(4) :496--99
- Crook MA , John CP , Dphil PJ , et alRelationship between plasma SA concentration and microvascular and macrovascular complications in type 1 diabetes.Diabetes care 2001 ;24 (2) :316-22
- Kario K and Matsuo T Relation between SA concentrations and haemostatic system in the elderly .BMJ 1993 ;306 : 1650-51
- Gokmen SS , Kilicli G Ozcelik F et al Association between serum TSA and LASA concentrations and the severity of coronary atherosclerosis . J.Lab.Clin.Med. 2002 ;140 : 110-18
- Van Dijk W , Pos O , Van der Stelt ME , et al Inflammation –induced changes in expression and glycosylation of genetic variants of alpha 1 –acid glycoprotein . Studies with human sera , primary culture of human hepatocytes and transgenic mice . Biochem. J. 1991 ;276 : 343-47
- Knuiman MW , Watts GF , Divitini MLIs SA an independent risk factor for cardiovascular disease ? .A 17-year follow up study in Busselton ( Western Australia ) .Ann. Epidemiol. 2004 ; 14 (9) : 627-32
- Katapoids N , Hirshaut Y , Geller NL et alLipid-associted sialic acid test for detection oh human cancer Cancer Res. 1982 ; 42 : 5270-75
- Guzel M , Tunay KA , Galip K et al Serum sialic acids , total antioxidant capacity , and adenosine deaminase activity in cattle with theileriosis and anaplasmosis. Bull. Vet. Inst. Pulaway 2008 ; 52 : 227-30
- Wayne W .D.Biostatistics , 8 ed , John Wiley and Sons , USA , 2005
- Majid Amir AM , Rezaei M , Goodarzi MT , et al Some biomarkers in AMI.Res Health Sci , 2007 ; 7 (2) :11-19
- Lovlien MBS and Torstein H Women with MI are less likely than men to experience chest symptoms .Scandinavia Cardiovascular J , 2006 ; 40 : 342-47
- Inayat –Ur-Rahman , Malik SA , Wilayat AK Relation of serum SA with serum lipids in cardiac patients. Pakistan J. of Pharmaceutical Sci. , 2005 ; 18 : 71-73
- Gokmen SS , Kilicli G , Ozcelik F et al Serum total lipid bound –SA levels following AMI. Clin. Chem. Lab. Med. , 2000 ;38 :1249—55
- Lindberg G , Eklund GA , Gullberg BO Serum SA concentration and cardiovascular mortality .BMJ 1991 ; 302 :143-45
- Allain P , Olivier E , Le Brouil A et al Increase of TSA concentration in the plasma of patients with coronary disease .Presse Med. 1996 ;25 : 96-8
- Gokmen S , Kazezoglu C , Bendigar S et al Relationship between serum SA , SA-rich inflammation-sensitive proteins and cell damage in patients with AMI. Clin. Chem. Lab. Med. 2006 ; 44(2) :199-206
- Berkan O and Sagban M Sialic acid or troponin T to detect perioperative myocardial damage in patients undergoing coronary artery bypass grafting. Cir. J. 2002 ; 66 : 1019-23
- Sonmez H , Ozturk ZG , Ulutin Tet al Carbohydrate deficient transferring and sialidase levels in CHD Thromb Res. 2000 ;99 : 311-5
- Nigam PK , Narain VS , Chandra N et al.Serum and platelet SA in AMI. Ind .J. Clin Bioch 1995 ;10 : 106-9
- Reganon E , Martinez –Sales V , Vila V et al .Relationship between fibrinogen protein and fibrinogen function in postmyocardial infarction patients .Thromb Res 2001 ;104 : 413-19
- Karagenc T , Ilhan C , Karagin kf ,et al .Detection of serum TSA in cattle with natural tropical theileriosis. Rev. Med. Vet. , 2005 ; 156 : 578-82
- Breen KC The role of protein glycosylation in the control of cellular sialyltransferase activity. Fees Lett. , 2002 ;517 : 215-18.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2011 Rasul Sulayman Aziz, Tayfoor Jalil Mahmoud, Hamid G. Hassan (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The copyright on any article published in Zanco J Med Sci is retained by the author(s) in agreement with the Creative Commons Attribution Non-Commercial ShareAlike License (CC BY-NC-SA 4.0).
