Evaluation of vitamin c & malondialdehyde levels in type 2 diabetes mellitus

Amanj Zrar Hassan; Leweza B. Abbass

doi:10.15218/zjms.2011.030

Authors

Amanj Zrar Hassan Department of clinical biochemistry , Clinical biochemistry , Hawler Medical University, Erbil, Iraq
Leweza B. Abbass Department of clinical biochemistry, Clinical biochemistry, Hawler Medical University,Erbil, Iraq

DOI:

https://doi.org/10.15218/zjms.2011.030

Keywords:

Type 2 diabetes, plasma vitamin C, serum (MDA) lipid profiles

Abstract

Background and objectives: Diabetes mellitus is a metabolic disorder, characterized by hyperglycemia. The oxidative stress in diabetes was greatly increased due to prolonged exposure to hyperglycemia and impairment of oxidant /antioxidant equilibrium. Proteins and lipids are among the prime target for oxidative stress. The objective of this study was to find out correlation between lipid peroxidation in terms of malondialdehyde (MDA) and impairment of antioxidant in terms of vitamin C (Vit C) to severity and complication of type 2 diabetes mellitus.

Methods: We study a total of 163 subjects among them 109 patients were type 2 diabetic patients and remaining 54 subjects were healthy control subjects. Fasting blood samples were collected in Layla Qasm center for diabetes /Hawler city and analyzed for plasma vitamin C, serum MDA, serum lipid profile and serum glucose in the research lab of Clinical Biochemistry College of Medicine/ Hawler.

Results: Plasma vitamin C levels were significantly decreased in diabetes mellitus (0.48 ± 0.026) mg/dl compared to non- diabetic patients (1.18 ± 0.057) mg/dl. Patients with type 2 diabetes showed a significant increase in serum MDA (1.52 ± 0.04) mmol/L in comparison to non- diabetic patients (0.73 ± 0.026) mml/L.

Conclusion: In this study group, there is significant correlation between lipid peroxide concentration and lipid fractions except vitamin C and HDL-cholesterol.

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