Dual effects of aspirin and Garcinia Cambogia on human blood viscosity


  • Hayder M. Al-kuraishy Department of pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq.
  • Basim S. N. Al-Mgoter Department of Internal Medicine, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq.
  • Ali Ismai A. Al-Gareeb Department of pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq.




Blood viscosity, Aspirin, Garcinia cambogia


Background and objective: Prevention of bacterial adhesion is an attractive target for the development of new therapies in the prevention of bacterial infection. The aim of this study is to investigate the effects of pomegranate peel extract, vitamin C, combination of pomegranate peel extract and vitamin C & gemifloxacin on adhesion of E.coli to uroepithelial cells. 

Methods: This study was conducted in the Department of Pharmacology, college of Medicine, AL-Mustansirya University in 2009. Twenty patients with peripheral vascular diseases enrolled in this study. Those patients randomly allocated equally into two groups; group (A) received aspirin oral tablets 300 mg/day and group (B) received aspirin oral tablets 300 mg/day plus Garcinia cambogia oral tablets 500mg/day. The duration of therapy was two weeks. In this study, measurements were done for total blood viscosity, packed cell volume, serum fibrinogen, and serum cholesterol, before treatment as control and after one and two weeks of treatment.

Results: After 2 weeks treatment with aspirin there was significant reduction in plasma fibrinogen (p < 0.05). Combined aspirin and Garcinia Cambogica treatment for 2 weeks produce significant reduction in all blood viscosity parameters (p<0.05) except the packed cell volume which was not affected (p >0.05).

Conclusion: Aspirin and Garcinia cambogia produced significant and better effects than aspirin alone on blood viscosity.


Metrics Loading ...


Dintefass L.. Blood viscosity, hyperviscosity and hyperviscosaemia. MTP press, Lancaster. 1985; pp: 95 – 105.

Caimi G, Sinagra D, Scarpitta AM, Lo R. Presti Plasma viscosity and insulin resistance in metabolic syndrome. Int J Obes Relat Metab Disord 2001;25: 1856-7.

Soni MG, Burdock GA, Preuss HG, et al. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol 2004;42(9):1513-1529.

Shara, M., Ohia, S.E., Schmidt, R.E., Yasmin, et al. Physico-chemical properties of a novel (-)-hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days. Molec. Cell Biochem., 2004; 260(1-2):171-186.

Jena B, Jayaprakasha G, Singh R, Sakariah K. Chemistry and biochemistry of – hydroxycitric acid from Garcinia cambogia. J Agric Food Chem. 2002; 50(1): 10-22. 6.Dunkan R.: Blood viscosity determinants in familial hypercholestremia J. Int Med 1985; 238:451 – 52.

De Simone G, Devereux RB, Chien S, et al. Relation of blood viscosity to demographic and physiologic variables and to cardiovascular risk factors in apparently normal adults. Circulation. 1990;81(1):107–117.

Chien S. Shear dependence of effective cell volume as a determinant of blood viscosity. Science. 1970;168(934): 977–979.

H.-Y. Lin, S.-C. Shen, and Y.-C. Chen, “Anti-inflammatory effect of heme oxygenase 1: glycosylation and nitric oxide inhibition in macrophages,” Journal of Cellular Physiology, 2005; 202( 2): 579–590.

Hovens MMC, Snoep JD, Eikenboom JCJ, van der Bom JG, Mertens BJA, Huisman MV. Prevalence of persistent platelet reactivity despite use of aspirin: a systematic review. Am Heart J. 2007; 153(2):175-181.

Cerrello A, Paolisso G. Oxidative stress and antioxidant in diabetes mellitus. Am Med J 2003; 44 (3): 63 – 4.

L.A., Pagnin, E., Davis, P.A., Semplicini, A., Nicolai, R., Calvani, M., Pessina, A.C ,. Antioxidant effect of L-carnitine and its short chain esters: relevance for the protection from oxidative stress related cardiovascular damage. Int. J. Cardiol.2006; 107: 54-60.

Hegele R.: The role of simvastatin in cardiovascular disease and lipid peroxidation: lessons from rare mutation and special population. Clin Invest Med 2006;19: 161 – 70.

Kolodziejczyk, J, Masullo M, Olas B, Piacente S, Wachowicz, B. Effects of garcinol and guttiferone K isolated from Garcinia cambogia on oxidative / nitrative modifications in blood platelets and plasma. Platelets 2009; 20: 487−492

Berkhout A., Havekes LM, Pearce NJ and Groot PHE. The effect of (-)- hydroxycitrate on the activity of the lowdensity-lipoprotein receptor and 3-hydroxy-3-methylglutaryl- CoA reductase levels in the human hepatoma cell Hep G2. Biochem. J. 1990; 272: 181.

Cherniak, E.P. Potential application for alternative medicine to treat obesity. Altern Med Rev 2008; 13:34-42.




How to Cite

Al-kuraishy, H. M., Al-Mgoter, B. S. N., & A. Al-Gareeb, A. I. (2013). Dual effects of aspirin and Garcinia Cambogia on human blood viscosity. Zanco Journal of Medical Sciences (Zanco J Med Sci), 17(3), 514–517. https://doi.org/10.15218/zjms.2013.0042



Original Articles