Effects of welding fume particles on heamatological parameters in male Albino rats
Background and objective: Exposure evidence to welding fume aerosols demonstrates that particulate air pollutants can cause both pulmonary and airway inflammation. However, few data show that particulates pollutants can induce systemic inflammatory responses in animals. The aim of this study was to test whether exposure to welding fume by inhalation of its fine and ultra fine particles and different compositions of the electrical welding processes would produce physiological disorders for the blood parameters of exposed rat’s animal.
Methods: We conducted the study using hematology coulter counter to analyze whole blood samples of rats after exposure to welding fumes. We investigated the effect of wielding fume exposure on some hematological parameters such as the red blood corpuscles (RBCs), white blood cells (WBCs) and platelet parameters. Fourteen male albino rats were randomly assigned to control or wielding fume inhalation.
Results: Significant decrease were observed after four weeks of wielding fume inhalation in the hemoglobin (Hb) concentration, RBCs count, hemoglobin (Hb), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), red distribution width (RDW), mean corpuscular hemoglobin concentration (MCHC), Platelete counts (PLTs) and platelete large cell ratio ( P-LCR ).On the other hand, platelet distribution width (PDW).
Conclusion: We conclude that inhalation of wielding fume for a long time influence the progression of anemia and inflammation suggesting that welding fume profoundly affects whole-blood profiles.
Burgess WA. Recognition of health hazards in industry. A review of materials and processes. New York, John Wiley and Sons, Inc;1995
Glinsmann PW and Rosenthal FS.Evaluation of an aerosol photometer for onitoring welding fume levels in a shipyard.J Am Ind Hyg Assoc.1985;46:391–5.
Mueller E and Seger D. Metal fume fever--a review. J Emerg Med. 1985; 2:271- 274.
Behrman A.J. Welders. In Occupational, Industrial, and Environmental Toxicology. Greenberg Mosby-Year Book, St Louis-Missouri. 1997;p 303-309.
Schwartz J. Air pollution and blood markers of cardiovascular risk.Environ Health Perspect. 2001;109: 405-409.
Clarke R, Coull B, Reinisch U, Catalano P, Killingsworth CR and Koutrakis P, et al. Inhaled concentrated ambient particles are associated with hematologic and bronchoalveolar lavage changes in canines. Environ Health Perspect. 2000; 108:1179–1187.
Gordon T, Nadziejko C, Schlesinger R and Chen LC. Pulmonary and cardiovascular effects of acute exposure to concentrated ambient particulate matter in rats. Toxicol Lett. 1998; 96-97:285-288.
Madden MC.. Health Prospects. New York, John Wiley and Sons, Inc; 1993
Gawlikowski J. White cells at war. Am J Nurs. 1992; 92:44-51.
Seaton A, Soutar A, Crawford V, Elton R, McNerlan S and Cherrie J. Particulate air pollution and the blood. Thorax. 1999;54:1027-1032.
Savage S, Lawrence J, Coull B, Okabe K, Wolde-Mariam W, Wellenius G.. Hematologic responses to inhalation of concentrated air particles (CAPs) and transient myocardial ischemia (MI). Am J Respir Crit Care Med. 2002;165:A304.
Bai, K.M., Krishnakumari, M.K., Ramesh, H.P., Shivanandappa, T., and Majumder, S.K. Short-term toxicity study of zinc phosphide in Albino rats (Rattus norvegicus). Indian J. exp. Biol. 1980;18(8): 854-857.
Blanc, P., Boushey, H.A., Wong, H., Wintermeyer, S. F., and Bernstein, M. S.. Cytokines in metal fume fever. Am. Rev. Respir. Dis. 1993;147:134-138.
Hansz J, Kozlowska- Skrzypezak M..Interferon-gamma-mediated suppression of erythroid progenitor growth by a HLA-DR and CD-4 positive subset of T lymphocytes in acute myeloid leukemia. Immunology. 1992;186:327- 338.
Faquin WC, Schneider TJ and Goldberg MA.Effect of inflammatory cytokines on hypoxia-induced erythropoietin production. Blood. 1992; 79:1987-1994.
Villaume, J. E., Wasti, K., Liss-Suter, D., and Hsiao, S. In Effects of Welding on Health.J Am Weldi Soci. 1979; 1: 111-113
Defalque, R.J. Pharmacology and toxicology of trichloroethylene. A critical review of the world literature.Clin. Pharmacol. Therapeut. 1961; 2:665-688.
Sotarieni, E.A., Sutinen, S., Arranto, A.J., and Pelkonen, R.O. Liver injury in subjects occupationally exposed to chemicals in low doses. Acta Med. Scand. 1982; 212:207-215.
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