Evaluation of serum levels of homocysteine, C-peptide and lipid profile in type I and type II diabetic patients in Hawler province/Iraq

Abdulrahman J Mohammed; Abdulkader A Alnakshabandi; Abdulrahman Al-Bazzaz

doi:10.15218/zjms.2013.0023

Authors

Abdulrahman J Mohammed Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Iraq
Abdulkader A Alnakshabandi Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Iraq
Abdulrahman Al-Bazzaz Department of Biochemistry, Faculty of Pharmacy, Al-Ahliyya Amman University

DOI:

https://doi.org/10.15218/zjms.2013.0023

Keywords:

Diabetes mellitus, Homocysteine, C-peptide, Lipid profile

Abstract

Background and objective: Diabetes mellitus is associated with many complications such as cardiovascular disease, even in the presence of intensive glycemic control. Homocystein takes part in the development of atherosclerosis and vascular injury and it is suggested to contribute in atherosclerotic process of diabetes mellitus. C-peptide recently used to diagnose diabetes.The present study was designed to evaluate serum levels of Homocysteine, C-peptide levels and lipid profile in diabetic patients.

Methods: This study includes 75 diabetic patients (35 type 1 and 40 type 2) and 30 controls. After 12 hours fasting, serum homocystiene, C-peptide, lipid profile, HbA1c and blood glucose were measured for patients and controls.

Results: The results showed that homocysteine level in type 1 and type 2 diabetic patients significantly increased as compared with controls. And the C-peptide level in type 1 diabetic patient was very low, while in type 2 diabetic patients and in controls was normal. The results also showed that the lipid profiles (except HDL) were increased in diabetic patients.

Conclusion: Serum homocysteine (Hcy) level and lipid profile (except HDL) are significantly elevated in diabetic patients. The C-peptide level in type 1 diabetic patient was very low, while in type 2 and controls was normal.

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