Association of pre-eclampsia with dyslipideamia
DOI:
https://doi.org/10.15218/zjms.2013.0021Keywords:
Pre-eclampsia, cholesterol, triglycerides, low density lipoprotein (LDL)Abstract
Background and objective: Pre-eclampsia and eclampsia are claimed to be associated with disturbances in lipid profile. The purpose of this study was to determine any significant association between pre-eclampsia/eclampsia with lipid profile disturbances.
Methods: This prospective study evaluated lipid profile in the second half of pregnancy in 38 pre-eclamptic, 21 ecalmptic woman and compared to 41 age matched healthy pregnant women served as a control for the period of February 2010 – January 2011. Results: Pre-eclamptic women showed a significant increase in the mean serum cholesterol concentration (243.9 mg/dL) during the second trimester when compared with the healthy pregnant controls (212.9 mg/dL), eclamptic women had even a significant higher cholesterol level at a mean of (288.1 mg/dL). Triglyceride level significantly increased in pre-eclamptic (281.7 mg/dL) and eclamptic women (307.4 mg/dL) compared to healthy pregnant control (207.5 mg/dL). LDL level also showed significant increase in pre-eclamtic {143.7 mg/dL} and eclamptic cases (156.5 mg/dL). HDL level though was decreased in pre-eclamptic {41.5 mg/dL} and eclamptic (40.8 mg/dL) but these changes were not significant.Conclusion: Pre-eclampsia and eclampsia are associated with dyslipidemia. This association may be significant in understanding the pathologic processes of preeclampsia and may help in developing strategies for prevention or early diagnosis of the disorder.
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References
Dutta DC. Hypertensive disorders in pregnancy 6th edition Hiralal K. editor. In: Text Book of Obstetrics.New Central Book Agency Kolkata, India; 2005. P: 222-223.
Vanderjagt DJ, Patel RJ, El-Nafaty AU, Melah GS, Crossey MJ, Glew RH. High density lipoprotein and homocysteine levels correlate inversly in preeclamptic women in northern Nigeria. Acta Obstet Gyneacol Scand 2004; 83(6):536-4.
Caren G, Solomon, Seely EW: Preeclampsia searching for cause New Eng J Med 2004; 350(7):641-23.
Packer CS. Biochemical markers and physiological parameters as indices for identifying patients at risk o f developng pre-eclam psia. J Hypertns 2005; 23 :( 1)45-6.
Enquobahrie DA, Williams MA, Butler CL, Frderick IO, Miller RS, Luthy DA Maternal plasma lipid concentration in early pregnancy and risk of preeclampsia. Am J Hypertens 2004; 17(7):574-81.
Fitzgerald DJ, Entman SS, Mulloy K, FitzGerald GA.Decreased prostacyclin biosyntesis preceding the clinical manifestation of pregnanvy-induced hypertension.Circulation 1987; 75: 956-73.
Redman CWG.Immunolgy of preeclampsia.Semin Perinatol 1991; 15: 257-262.
American College of Obstetricians and Gynecologists (ACOG, practice bulletin) Diagnosis and management of preeclampsia and eclampsia Washington: 2002.Int J Gynaecol Obstet 2002; 77: 67-75.
Bodnar LM, Ness RB, Harger GF, Roberts JM.Inflammation and triglycerides partially mediate the effect of prepregnancy body mass index on the risk of preeclampsia.Am J Epidemiol 2005; 162: 1198-206 .
Karl Winkler, Bright Wetzka, Mıcheal M. Hoffmann, Isolde Friedrich, Martina Kınner, Mannfred W et al.Triglyceride-Rich lipoproteins are associated with hypertension in preeclampsia.J Clin Endocrinol Metab 2003; 88: 1162-6.
Ray JG, Diamond P, Singh G, Bell CM.Brief overview of maternal triglycerides as a risk factor for pre-eclampsia. BJOG 2006; 113: 379-86.
Baksu B, Baksu A, Davas I, Akyol A, Gülbaba G.Lipoprotein(a) levels in women with pre-eclampsia and in normotensive pregnant women. J Obstet Gynaecol Res 2005; 31: 277-82.
Enquobahrie DA, Williams MA et al.Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia. Am J Hypertens 2004; 17(7):574-81.
Adegoke, O.A., Iyare, E.E. and Gbenebitse, S.O. Fasting plasma glucose and cholesterol levels in pregnant Nigerian women Niger.Postgrad. Med. J. 2003; 10(1), 32-6.
Jayanta De, Ananda Kumar & Pradip Kumar Sah: Study of serum lipid profile in pregnancy induced hypertension Indian J. of Clinical Bioch, 2006; 21 (2) 165-168.
Enquobahrie, D.A., Williams, M.A et al:Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia, Am. J. Hypertens 2004; 17(7), 574-81.
Cekmen, M.B., Erbagci, A.B et al. Plasma lipid and lipoprotein concentrations in pregnancy induced hypertension, Clin. Biochem 2003; 36(7), 575-8.
Sattar, N., Bendomir, A.et al: Lipoprotein subfraction concentrations in preeclampsia: pathogenic parallels to atherosclerosis, Obstet. Gynecol. 1997; 89(3), 403-8
Gractacose E, Casals E, et al. Increased susceptibility to low density lipoprotein oxidation in women with a history of pr-eclampsia Br J Obstet Gynaecol. 2003; 110(4):400-4.
Özgür Ö, Ayhan C, et al: To evaluate the role of lipid profile in the etiopathogenesis of mild and severe preeclampsia Perinatal Journal 2008; 16(3):75 – 81.
Lorentsen, B. and Henriksen, T.: Plasma lipids and vascular dysfunction in pre-eclampsia. Semin Reprod. Endocrinol 1998 16(1), 33-39.
Belo, L. Caslake, M. et al Changes in LDL size and HDL concentration in normal and preeclamptic pregnancies. Atherosclerosis 2002: 162:425-43.
Duckitt, K., and Harrington, D. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. Bmj 2005; 330:565.
Caren, G. Solomon, Seely, E.W. Pre-eclampsia-searching for cause. New Eng J Med 2004. 350(7):641-2.
Attahir A, Mohammed M, Adamu B Girei : Lipid Profiles and Platelets Counts of Pre-eclamptic women in Selected Rural Areas of Northern Nigeria WebmedCentral Physiology 2011; 2(8): WMC002121.
Kaaja R, Tirkkanen MJ, Viinnkka L, Ylikorkala O. Serum lipoproteins, insulin and urinary prostanoid metabolites in normal and hypertensive pregnant women. Obstet Gynecol. 1995; 85(3):353-6.
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