The potential role of malondialdehyde, glutathione peroxidase, and interleukin-18 in the development of essential hypertension

Salar Fatih Kudhur; Shatha Rouf Moustafa

doi:10.15218/zjms.2018.030

Authors

Salar Fatih Kudhur Ministry of Heath, Erbil, Iraq
Shatha Rouf Moustafa Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Iraq

DOI:

https://doi.org/10.15218/zjms.2018.030

Keywords:

Essential Hypertension, Malondialdehyde, Glutathione Peroxidase, Interleukine -18

Abstract

Background and objectives: The oxidative stress and inflammatory process are cooperative events involved in the development of essential hypertension. This study was as a step for elucidating the contribution of the malondialdehyde, glutathione peroxidase, interleukin -18 and lipid profile with the development of essential hypertension. This study aimed to assess whether the variation in serum malondialdehyde, glutathione peroxidase, interleukin-18 and lipid profile levels were associated with the development of essential hypertension, moreover, find out the effect of age, gender and stage on the serum focused parameters levels and finally detect the correlation coefficient.

Methods: This case-control study was performed at the College of Pharmacy, Hawler Medical University in newly diagnosed and untreated patients with essential hypertension of both genders, and 50 of the matched age–gender healthy adults as a control group in the period between 2013-2014.

Results: Patients exhibited a significant elevation in the serum malondialdehyde, glutathione peroxidase, interleukin-18 and lipid profile levels.

Conclusion: This investigation provided for the first evidence the ability of selected parameters in combination patterns as factors involved in essential hypertension pathophysiology and are regarded as markers of diagnostic significance. The demonstration of these parameters provided new insights into understanding the independence of antioxidant status and inflammatory pathways in essential hypertension development.

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References

Ahmad A, Singhal U, Hossain MM, Islam N, Rizvi I. The role of the endogenous antioxidant enzymes and malondialdehyde in essential hypertension. J Clin Diagn Res 2013; 7(6):987–90.

Dinh QN, Drummond GR, Sobey CG, Chrissobolis S. Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension. Biomed Res Int 2014; 2014:406960.

Aquil A, Mohd MH, Usha S, Najmul I. Comparative study of marker of oxidative stress among normotensive, pre-hypertensive and hypertensive subjects. Biomedical Research 2013; 24(4):493–7.

Wilcox CS, Pearlman A. Chemistry and antihypertensive effects of tempol and other nitroxides. Pharmacol Rev 2008; 60:418–69.

Selvaraj N, Sathiyapriya V, Bobby Z, Nandeesha H, Aparna A. Elevated glutathione peroxidase in newly diagnosed hypertension: its relation to insulin resistance. Clin Exp Hypertens 2013; 35(3):195–9.

Rabkin SW. The role of interleukin 18 in the pathogenesis of hypertension-induced vascular disease. Nat Clin Pract Cardiovasc Med 2009; 6(3):192–9.

Chobanian AV, Bakris G L, Black H R. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA 2003; 289(19):2560– 72.

Lee R, Margaritis M, Channon K M, Antoniades C. Evaluating oxidative stress in human cardiovascular disease: methodological aspects and considerations. Curr Med Chem 2012; 19(16):2504–20.

Kotur-Stevuljevic J, Memon L, Stefanovic A. Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients. Clin Biochem 2007; 40:181–7.

Komala PT, Sankar P, Malliga S. Comparative Study of Antihypertensive Treatment with Enalapril and Atenolol on Oxidative Stress. JPBS 2013; 5(4):8–11.

Evans J, Collins M, Jennings C, van der Merwe L, Soderstrom I, Olsson T, et al. The association of interleukin-18 genotype and serum levels with metabolic risk factors for cardiovascular disease. Eur J Endocrinol 2007; 157(5):633–40.

Kosugi T, Nakagawa T, Kamath D, Johnson RJ.Uric acid and hypertension: an age-related relationship?. J Hum Hypertens 2009; 23(2):75–6.

Tassaduqe K, Ali M, Salam A, Latif M. Hypertension in Relation to Obesity, Smoking, Stress, Family History, Age and Marital Status among Human Population of Multan. Pak J Med Sci 2004; 35:30–5.

Levenson JW, Skerrett PJ, Gaziano JM. Reducing the global burden of cardiovascular disease: the role of risk factors. Prev Cardiol 2002; 5:188–99.

Taddei S, Ghiadoni L, Virdis A, Versari D, Salvetti A. Mechanisms of endothelial dysfunction: clinical significance and preventive non-pharmacological therapeutic strategies. Curr Pharm 2003; 9:2385–402.

Rybka J, Kupczyk D, Kędziora-Kornatowska K, Pawluk H, Czuczejko J, Szewczyk-Golec K. Age-related changes in an antioxidant defense system in elderly patients with essential hypertension compared with healthy controls. Redox Rep 2011; 16(2):71–7.

Kasapoglu M, Ozben T. Alterations of antioxidant enzymes and oxidative stress markers in aging. Exp Gerontol 2001; 36(2):209–20.

Erden-Inal M, Sunal E, Kanbak G. Age-related changes in the glutathione redox system. Cell Biochem Funct 2002; 20:61–6.

Rebrin I, Sohal RS. Pro-oxidant shift in glutathione redox state during aging. Adv Drug Deliv Rev 2008; 60(13-14):1545–52.

Augustyniak A, Skrzydlewska E. Antioxidative abilities during aging. Postepy Hig Med Dosw 2004; 58:194–201.

Frayling TM, Rafiq S, Murray A, Hurst AJ, Weedon MN, Henley W, et al. An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people. J Gerontol A Biol Sci Med Sci 2007; 62(1):73–8.

Pavão M, Cordeiro C, Costa A, Raposo J, Santos M, Nève J, et al. Comparison of whole-blood glutathione peroxidase activity, levels of serum selenium, and lipid peroxidation in subjects from the Fishing and Rural Communities of “Rabo de Peixe” village, San Miguel Island, the Azores’ Archipelago, Portugal. Biol Trace Elem Res 2003; 92:27–40.

Yamagami H, Kitagawa K, Hoshi T, Furukado S, Hougaku H, Nagai Y, et al.Associations of Serum IL-18 Levels With Carotid Intima-Media Thickness. Arterioscler Thromb Vasc Biol 2005; 25(7):1458–62.

Das S, Yadav D, Narang R, Das N. Interrelationship between lipid peroxidation, ascorbic acid and superoxide dismutase in coronary artery disease. Curr Sci 2002; 83(4): 488–91.

Busserolles J, Mazur A, Gueux E, Rock E, Rayssiguier Y. Metabolic syndrome in the rat: Females are protected against the pro-oxidant effect of a high sucrose diet. Exp Biol Med 2002; 227:837–42.

Simic DV, Mimic-Oka J, Pljesa-Ercegovac M. Byproducts of oxidative protein damage and antioxidant enzyme activities in plasma of patients with different degrees of essential hypertension. J Hum Hypertens 2006; 20:149–55.

Kedziora-Kornatowska K, Czuczejko J, Pawluk H, Kornatowski T, Motyl J, Szadujkis-Szadurski L, et al. The markers of oxidative stress and activity of the antioxidant system in the blood of elderly patients with essential arterial hypertension. Cell Mol Biol Lett 2004; 9:635–41.