Copyright and Licensing:
Copyright (c) 2015 Ali A. Alzubaidee, Shaheen Ali Ahmed (Author)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
- Articles
- Submited: September 24, 2018
-
Published: April 1, 2015
Abstract
Lethal midline granuloma syndrome is a clinical term used generally to describe a rare clinical entity, of unknown aetiology, characterized by progressive destruction of face, nose, para-nasal sinuses, and palate, oral and para-oral structures. Diagnosis is often difficult and requires expert clinical and histopathological examination of the lesion. A case of advanced high–grade lymphoma is reported as it was misdiagnosed and not treated properly for several months. After final diagnosis, a combined radio and chemotherapy were offered to the patient, but unfortunately the patient died because there was no response to treatment.Metrics
Metrics Loading ...
References
- Joseph HG. Lymphoreticularand granulomatous disorders of Head and Neck.In: Stanley ET, William R. Panje, editors. Comprehensive management of Head and Necktumors. philadelphia: WB Sanders; 1987. P. 1871-3.
- KmuchaS, Randall DA.Haward Patrickboey, highlights and preals. In: Lee KJ editors. Essential otolaryngology, Head and Neck Surgery, 7th ed. United States: McGraw Hill; 1998. P. 1136.
- MendenhallWM, Olivier KR, Lynch JW, Mendenhall NP.Lethal midline granuloma-nasal natural killer/T cell lymphoma. Am J ClinOncol 2006; 29:202-6.
- Hon C, Kwok Ak, Shek TW, Chim JC,Au WY. Vision-threatening complications of nasal T/NK lymphoma. Am J Ophthalmol 2002; 134: 406-10.
- Rodrigo JP, Suarez C, Rinaldo A,Devaney KO, Carbone A, Barnes L et al. Idiopathic midline destructive disease: fact or fiction. Oral Oncol 2005; 41: 340-8.
- Gourin, CG, Johnson JT, Selvaggi K. Nasal T-cell lymphoma: case report and review of diagnostic features. Ear Nose Throat J 2001; 80: 458-60.
- Yang Y, Gan JP, Chang SM .Malignant lymphoma of sinonasal region, including cases of polymorphic reticulosis .Chin Med J 1997; 60:236-44.
- Abbondanzo SL, Wenig BM. Non-Hodgkins lymphoma of the sinonasal tract .Cancer 1995; 75(6):1281-91.
- Jaffe ES, Chan JK, Su IJ. Report of the workshop on nasal and related extranodalagiocentic natural killer cell lymhpomasdefinitions, differential diagnosis and epidemiology. Am J SurgPathol1996; 20:103-11.
- Baker THW, Hosni AA. Pathology in focus, Idiopathic midline destructive disease does it exists? JLaryngand Otol1998; 112:307-9.
- Califano L, ZupiA, Maremonti P, De Rosa G. Sinonasal lymphoma presenting as a lethal midline granuloma: Case report. J Oral MaxillofacSurg1998; 56: 667-71.
- Wolff SM. Midline granuloma. Harrisons principles of internal Medicine, 13th ed. NewYork : McGraw Hill; 1994.1886-7.
- Jameson JL, Longo DL. Malignancies of lymphoid cells Harrisons principles of internal Medicine, 16thed. New York: McGraw Hill; 2005.654.
- Takahashi E, Asano N, Li C, Tanaka T, Shimada K, Shimada S, et al . Nodal T/NK-cell lymphoma of nasal type: a clinicopathological study of six cases. Histopathology2008; 52:585-96.
How to Cite
Alzubaidee, A. A., & Ahmed, S. A. (2015). Midline lethal granuloma: Case report and review of literature. Zanco Journal of Medical Sciences (Zanco J Med Sci), 19(1), 935_937. https://doi.org/10.15218/zjms.2015.0002