The effect of sialoprotein local injection on dental anchorages for orthodontic tooth retraction in dogs

Omar Fawzi Chawshli; Rafah Al- Maroof; Fadhil Y. Jasim

doi:10.15218/zjms.2014.0032

Authors

Omar Fawzi Chawshli Department of P.O.P, College of Dentistry, Hawler Medical University, Erbil, Iraq.
Rafah Al- Maroof Department of Oral Diagnosis, College of Dentistry, Hawler Medical University, Erbil, Iraq
Fadhil Y. Jasim Department of P.O.P, College of Dentistry, Mosul University, Mosul, Iraq

DOI:

https://doi.org/10.15218/zjms.2014.0032

Keywords:

Sialoprotein, Mini-implant, Dental Anchorage

Abstract

Background and objective: Bone sialoprotein is a mineralized tissue-specific protein expressed in differentiated osteoblasts that appear to function in the initial mineralization of bone. The aim of this study was to investigate the effect of local bone sialoprotein on increasing the rate of anchorage during orthodontic tooth movement.

Methods: This study used 14 dogs wearing orthodontic appliance for 40 days. They were divided equally into two groups; experimental group that injected with 0.1 µg /10µL sialoprotein around the anchoring tooth in three different time intervals, while the other control group received normal saline injection. Different clinical measurements including loss of anchorage, space closure, rotation, tipping and extrusion were done on the stone casts of each dog before and after tooth retraction.

Results: Clinical measurements revealed a highly significant difference between experimental and control group regarding loss of anchorage and space closure. The sialoprotein injected group showed less loss of anchorage than control group and the space closure was higher in experimental group than in the control group.

Conclusion: This study showed that the local injection of sialoiprotein reduced movement of the anchoring tooth during orthodontic treatment and provided higher stability for the anchoring tooth.

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References

Geron S, Shpack N, Kandos S, Davidovitch M, Vardimon AD. Anchorage loss-a multifactorial response. Angle Orthod 2003; 73:730-7.

Esenlik E, Naziroğlu M, Açikalin C , Övey IS. Vitamin E supplementation modulates gingival crevicular fluid lipid peroxidation and antioxidant levels in patients with orthodontic tooth movement. Cell Biochem Funct 2012; 30:376-81.

Bartzela T, Türp JC, Motschall E, Maltha JC. Medication effects on the rate of orthodontic tooth movement: a systematic literature review. Am J Orthod Dentofacial Orthop 2009; 135: 16-26.

Ong CKL, Joseph BK, Waters MJ, Symons AL. Growth hormone receptor and IGF-I receptor immunoreactivity during orthodontic tooth movement in the prednisolone-treated rat. Angle Orthod 2001; 71:486-93.

Kim JY, Kim BI, Jue SS, Park JH , Shin JW. Localization of osteopontin and osterix in periodontal tissue during orthodontic tooth movement in rats. Angle Orthod 2012; 82:107-14.

Gameiro GH, Pereira-Neto JS, Magnani MB, Nouer DF. The influence of drugs and systemic factors on orthodontic tooth movement. J Clin Orthod 2007; 41:73-8.

Kohno S, Kaku M, Kawata T, Fujita T, Tsutsui K , Ohtani J, et al. Neutralizing effects of an anti-vascular endothelial growth factor antibody on tooth movement. Angle Orthod 2005; 75: 797-804.

Liu L, Igarashi K, Haruyama N, Saeki S, Shinoda H, Mitani H. Effects of local administration of clodoronate on orthodontic tooth movement and root resorption in rats. Eur J Orthod 2004; 26:469-73.

Saddi KRGC, Alves GD, Paulino TP, Ciancaglini P, Alves JB. Epidermal growth factor in liposomes may enhance osteoclast recruitment during tooth movement in rats. Angle Orthod 2008; 78:604-9.

Chaplet M, Detry C, Deroanne C, Fisher LW, Castronovo V, Bellahcene A. Zoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPases inhibition. Biochem J 2004; 384:591-8.

Wang S, Sasaki Y, Ogata Y. Calcium hydroxide regulates bone sialoprotein gene transcription in human osteoblast-like saos 2 cells. J Oral Sci 2011; 53:77-86.

Bellahcène A, Castronovo V. Expression of bone matrix proteins in human breast cancer: potential roles in microcalcification formation and in the genesis of bone metastases. Bull Cancer 1997; 84:17-24.

Zhang L, Hou X, Lu S, Rao H, Hou J, Luo R, et al. Predictive significance of bone sialoprotein and osteopontin for bone metastases in resected Chinese non-small-cell lung cancer patients: a large cohort retrospective study. Lung Cancer 2010; 67:114-9.

Goldberg HA, Baht G, Gordon J, Pitelka V, Chen H, Holdsworth D, et al. Bone Repair Mediated by Bone Sialoprotein. Eur Cell Mater 2008; 16:47.

Riminucci M, Bianco P. Building bone tissue: matrices and scaffolds in physiology and biotechnology. Braz J Med Biol Res 2003; 36:1027-36.

Malaval L, Wade-Gueye NM, Boudiffa M, Fei J, Zirngibl R, Chen F, et al. Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis. J Exp Med 2008; 205:1145-53.

Hilbig H, Kirsten M, Rupietta R, Graf HL, Thalhammer S, Strasser S, et al. Implant surface coatings with sialoprotein, collagen, and fibronectin and their effects on cells derived from human maxillary bone. Eur J Med Res 2007; 12:6-12.

Madan MS, Liu ZJ, Gu GM, King GJ. Effect of human relaxin on orthodontic tooth movement and periodontal ligament in rats. Am J Orthod Dentofacial Orthop 2007; 131:8e1-10.

Gonzales C, Hotokezaka H, Karadeniz EI, Miyazaki T, Kobayashi E. Effects of fluoride intake on orthodontic tooth movement and orthodontically induced root resorption. Am J Orthod Dentofacial Orthop 2011; 139:196-205.

Hashimoto F, Kobayashi Y, Mataki S, Kobayashi K, Kato Y, Sakai H. Administration of osteocalcin accelerates orthodontic tooth movement induced by closed coil spring in rats. Eur J orthod 2001; 23:535-45.

Kobayashi Y, Takagi H, Sakai H, Hashimoto F, Mataki S, Kobayashi K, et al. Effect of local administration of osteoclacin on experimental tooth movement. Angle Orthod 1998; 68(3): 259-66.

Soma S, Matsumoto S, Higuchi Y, Takano-Yamamoto T, Yamashita K , Kurisu K, et al. Local and chronic application PTH accelerates tooth movement in rarts. J Dent Res 2000; 79:1717-24.

Seifi M, Eslami B , Saffar AS. The effect of prostaglandin E2 and calcium gluconate on orthodontic tooth movement and root resorption in rats. Eur J Orthod 2003; 25:199-204.

Curtin P, McHugh KP, Zhou H, Flückiger R, Goldhaber P , Oppenheim FG, et al. Modulation of Bone Resorption by Phosphorylation State of Bone Sialoprotein. J Biochem 2009; 48:6876-86.

Tye CE, Rattray KR, Warner KJ, Gordon JA, Sodek J, Hunter GK, et al. Delineation of the hydroxyapatite nucleating domains of bone sialoprotein. J Biol Chem 2003; 278:7949-55.

Wang D, Christensen K, Chawla K, Xiao G, Krebsbach PH , Franceschi RT. Isolation and characterization of MC3T3- E1 preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential. J Bone Miner Res 1999; 14:893-903.

Valverde P, Tu Q, Chen J. BSP and RANKL induce osteoclastogenesis and bone resorption synergistically. J Bone Miner Res 2005; 20: 1669-79.

Razzouk S, Brunn JC, Qin C, Tye CE, Goldberg HA, Butler WT. Osteopontin posttranslational modifications, possibly phosphorylation, are required for in vitro bone resorption but not osteoclast adhesion. Bone 2002; 30:40-7.

Chen JK, Shapiro HS, Wrana JL, Reimers S, Heersche JN , Sodek J. Localization of bone sialoprotein (BSP) expression to sites of mineralized tissue formation in fetal rat tissues by in situ hybridization. Matrix 1991; 11:133-43.

Contri MB, Boraldi F, Taparelli F, De Paepe A, Ronchetti IP. Matrix proteins with high affinity for calcium ions are associated with mineralization within the elastic fibers of pseudoxanthoma elasticum dermis. Am J Pathol 1996; 148:569-77.

Yang L, Li Z, Li X, Wang Z, Wang S, Sasaki Y, et al. Butyric acid stimulates bone sialoiprotien gene transcription. J Oral Sci 2010; 52:231-7.

Sasaki Y, Wang S, Ogata Y. Transcriptional regulation of bone sialoprotein gene by CO2 laser irradiation. J Oral Sci 2011; 53:51-9.

O'Toole GC, Salih E, Gallagher C, FitzPatrick D, O'Higgins N, O'Rourke SK. Bone sialoprotein-coated femoral implants are osteoinductive but mechanically compromised. J Orthop Res 2004; 22(3):641-6.

Graf HL, Stoeva S, Armbruster FP, Neuhaus J, Hilbig H. Effect of bone sialoprotein and collagen coating on cell attachment to TICER and pure titanium implant surfaces. Int J Oral Maxillofac Surg 2008; 37(7):634-40.

Hoshi K, Ozawa H. Matrix Vesicle Calcification in Bones of Adult Rats. Calcif Tissue Int 2000; 66:430-4.

Caravlho RS, Bumann A, Schaffer JL, Grestenfeld LC. Predominant integrin ligands expressed by osteoblasts show preferential regulation in response to both cell adhesion and mechanical perturbation. J Cell Biochem 2002; 84:497-508.