Most commonly natural and synthetic antihyperlipidemic agents available and distracted in Erbil city
DOI:
https://doi.org/10.15218/zjms.2015.0030Keywords:
Hyperlipidemia, Natural products, Synthetic drugs, Erbil cityAbstract
Background and objective: Hyperlipidemia refers to elevated levels of lipids and cholesterol in the blood, and is also identified as dyslipidemia, to describe the manifestations of different disorders of lipoprotein metabolism. The aim of this study was to investigate the available and commonly distracted natural and synthetic antihyperlipidemic agents in herbal shops, pharmacies and prescribed by physicians in Erbil city, and to determine physicians' response for the use of natural products.
Methods: Between November 2013 to February 2014; 20 herbal shops and 40 pharmacies in Erbil city were visited randomly for asking on available and most commonly distracted natural and synthetic antihyperlipidemic agents. Forty doctors at private clinics were asked about the most frequently prescribed natural and synthetic antihyperlipidemic agents in Erbil city.
Results: Of eight synthetic drugs available in pharmacies, statins were considered the first line agents as antihyperlipidemic drugs particularly atorvastatin and rosuvastatin. Of 16 natural products available in Erbil herbal shops and pharmacies, garlic and omega 3 give positive response by patients and highly distracted by pharmacist and herbalist. Of 40 physicians, 27 (68%) prescribe both natural and synthetic agents while only 13 (32%) prescribe synthetic drugs as antihyperlipidemic agents for patients.
Conclusion: Statins used in first order as antihyperlipidemic drugs and uses of natural products, as lipid lowering agents in Erbil, is getting larger interest by people, herbalists, pharmacists and doctors. Of 40 doctors, 68% prescribe natural products along with synthetic drugs but also there is a need to educate the people on how to use these natural agents and choice suitable products for them.
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References
Mahmood ZA, Ahmed SW, Sualeh M, Mahmood SBZ. Hyperlipidemia development and consequences. Med Channel 2009; 5:14-17.
Ducharme N, Radhamma R. Hyperlipidemia in the elderly. Clin Geriatr Med 2008; 24:471-87.
Reiner Z, Tedeschi-Reiner E. Atherosclerosis – a paradox of Eastern European countries. Atherosclerosis 2006; 7:461.
Simons LA. Additive effect of plant sterol-ester margarine and cerivastatin in lowering low density lipoprotein cholesterol in primary hypercholesterolemia. Am J Cardiol 2002; 90:737.
Yokozawa T, Ishida A, Cho E J, Nakagawa T. The effects of Coptidis rhizoma extract on a hypercholesterolemic animal model. Phytomedicine 2003; 10:17.
Soutar AK, Naoumova RP. Mechanisms of disease: genetic causes of familial hypercholesterolemia. Nat Clin Pract Cardiovasc Med 2007; 4:214-25.
Ibrahim SRM, Mohamed GA, Banjar ZM, Kamal HKM. Natural antihyperlipidemic agents: Current status and future perspectives. Phytopharmacology 2013; 4(3):492-531.
Durington P. Dyslipidaemia. Lancet 2003; 362:717-31.
Farnier M. Cerivastatin in the treatment of mixed hyperlipidemia: the right study. The Cerivastatin Study Group. Cerivastatin, Gemfibrozil, Hyperlipidemia Treatment. Am J Cardiol 1998; 82:47-51.
Trevor AJ, Katzung BG. Clipstone N. Drugs used to treat Hyperlipidemia I & II. Pharmacology: Examination and Board Review. 9ed. Anthony J 2012; 605-17.
Naples M, Federico LM, Xu E, Nelken J, Adeli K. Effect of rosuvastatin on insulin sensitivity in an animal model of insulin resistance: evidence for statin-induced hepatic insulin sensitization. Atherosclerosis 2008; 198(1):94-103.
Souza TD, Mengi SA, Hassarajani S, Chattopadhayay S. Efficacy study of the bioactive fraction (F-3) of Acorus calamus in hyperlipidemia. Indian J Pharmacol 2007; 39(4):196-200.
Moser A, Segars LW: Assessment of antihyperlipidemic therapy in US patients with coronary heart disease. J Am Osteopath Assoc 2010; 110(6):331-39.
Tsujita T, Takaichi H, Takaku T, Aoyama S, Hiraki J. Antiobesity action of -polylysine, a potent inhibitor of pancreatic lipase. J Lipid Res 2006; 47:1852-58.
Farnsworth NR, Akerels O, Bingel AS, Soejarto DD, Guo Bull Z. Medicinal plants in therapy. Bull World Health Organ 1985; 63:965.
Ibraheem DA. Comparative study between plant and animal sources of Omega-3 fatty acid in their potential role of regulating blood glucose and lipid profile in healthy volunteers. Yemeni J Med Sci 2011; 5:7-14.
Yeh Y, Liu L. Cholesterol-lowering effect of garlic extracts and organosulfur compounds: Human and animal studies. The Am Soc Nutr Sci 2001; 131(3):9895-935.
Vijaimohan K, Jainu M, Sabitha KE, Subramaniyam S, Anandhan C, Shyamala Devi CS. Beneficial effects of alpha linolenic acid rich flaxseed oil on growth performance and hepatic cholesterol metabolism in high fat diet fed rats. Life Sci 2006; 79(5):448-54.
Kaatabi H, Bamosa AO, Lebda FM, Abdulmohsen H, Al-Sultan AI. Favorable impact of Nigella sativa seeds on lipid profile in type 2 diabetic patients. J Fam Commun Med 2012; 19(3):155–61.
Asgary S, Rafieian-Kopaei M, Najafi S, Heidarian E, Sahebkar A. Antihyperlipidemic effects of Sesamum indicum L. in Rabbits Fed a High-Fat Diet. The Sci World J 2013; 5.
Fuhrman B, Rosenblat M, Hayek T, Coleman R, Aviram M. Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein e-deficient mice. J Nutr 2000; 130(5):1124-31.
Yousaf MJ, Naveed AK, Ahmed T, Khan S, Azeem Z. Hypolipidemic effect of extra virgin olive oil in diabetic rats. J Rawal Med Col 2012; 16(1):70-72.
Jäger S, Trojan H, Kopp T, Laszczyk M, Scheffler A. Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts. Molecules 2009; 14: 2016-31
Suriyamoorthy P, Mary MRF, Subrhamanian H, Kanagasapabathy D. Anti hyperlipidemic effect of aqueous extract of Aegle marmelos and camellia sinensis in oil fed hyperlipidemic rats. Int J Pharm Sci, 2014; 6(2):338-41.
Vuyyuru A, Kotagiri S, Vrushabendra Swamy BM, Archana Swamy P. Antihyperlipidemic activity of Ananas Comosus L. leaves extract in Albino rats. Res J Pharma Biol Chem Sci 2012; 3(3):1229.
Leontowicz H, Leontowicz M, Gorinstein S, Martin-belloso O, trakhtenberg S. apple peels and pulp as a source of bioactive compounds and their influence on digestibility and lipid profile in normal and atherogenic rats. J Med weter 2007; 63(11):1434-6.
Qin Y, Xia M, Ma J, Hao YT, Liu J, Mou HY et al. Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. Am J Clin Nutr 2009; 90:485-92.
Udani JK, Singh BB, Singh VJ, Barrett ML. Effects of Açai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: a pilot study. Nutr J 2011; 10:45.
Englisch W, Beckers C, Unkauf M, Ruepp M, Zinserling V. Efficacy of Artichoke dry extract in patients with hyperlipoproteinemia. Arzneimittelforschung 2000; 50:260-65.
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